Protein Alignment CG12869 and ACHE

DIOPT Version :9

• Sequence 1: NP_001369085.1
• Gene: CG12869 / 36616
• FlyBaseID: FBgn0033943
• Length: 839
• Species: Drosophila melanogaster
• Sequence 2: NP_001354847.1
• Gene: ACHE / 43
• HGNCID: 108
• Length: 681
• Species: Homo sapiens
• Alignment Length: 613
• Identity: 159/613 - (25%)
• Similarity: 249/613 - (40%)
• Gaps: 166/613 - (27%)

  Fly    31 IKLEQGDLIGLKVFPDGTRGAVYAFLGIPYAQAPINELRFAPAKPSSSFNRTLQATTMQPLCPQL 95
            :.:..|.|.|:::...|  |.|.||||||:|:.|:...||.|.:|...::..:.|||.|.:|.|.
Human   108 VTVRGGRLRGIRLKTPG--GPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQY 170

  Fly    96 ANTIYD--ESSDGSMP-RSVSTDEDCLYLNIWTPESGMRYGK----LPIVVIVTGEEFAYDWPRN 153
            .:|:|.  |.::...| |.:|  |||||||:|||     |.:    .|::|.:.|..|     .:
Human   171 VDTLYPGFEGTEMWNPNRELS--EDCLYLNVWTP-----YPRPTSPTPVLVWIYGGGF-----YS 223

  Fly   154 RINGLD-------LAGEGIVVVSVQYRNNIYGWLSLGEQHRNVPGNYGLSDVQMALRWIRRNADA 211
            ..:.||       :..|..|:||:.||...:|:|:| ...|..|||.||.|.::||:|::.|..|
Human   224 GASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLAL-PGSREAPGNVGLLDQRLALQWVQENVAA 287

  Fly   212 FGGNPDHITLLGHGSGGAPLALVATLEDSSQVKQLVLMSP---GPIMRAL---GQNHQKW-IVET 269
            |||:|..:||.|..:|.|.:.             :.|:||   |...||:   |..:..| .|..
Human   288 FGGDPTSVTLFGESAGAASVG-------------MHLLSPPSRGLFHRAVLQSGAPNGPWATVGM 339

  Fly   270 GQV------LVQKLGCQ--FEEAQRRQLMGCLRRKSREDLLRAYESVYNHGNGSSQLGVILPEGL 326
            |:.      |...:||.  .......:|:.|||.:..:.|:       ||     :..|     |
Human   340 GEARRRATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLV-------NH-----EWHV-----L 387

  Fly   327 PLEQRLRNKTLP-----------------------PVLLGITSNEGAFLQDYWLDVAREGQVALH 368
            |.|...|...:|                       .||:|:..:||::...|       |.....
Human   388 PQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVGVVKDEGSYFLVY-------GAPGFS 445

  Fly   369 KYINHTLLPNV-MRALESVGEESSTQLAA-------IRWRYFNGKGEGVSHLLAGMQRLLSESLY 425
            | .|.:|:... ..|...||....:.|||       ..|.:    .|..:.|...:..::.:...
Human   446 K-DNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLH----PEDPARLREALSDVVGDHNV 505

  Fly   426 ELPYSRILELL--NGTTSYAYVFDHSHSMDMRGRRN-----LFGGASHSSDLPLLLG----PSLF 479
            ..|.:::...|  .|...|||||:|        |.:     |:.|..|..::..:.|    ||
Human   506 VCPVAQLAGRLAAQGARVYAYVFEH--------RASTLSWPLWMGVPHGYEIEFIFGIPLDPS-- 560

  Fly   480 QQIARRRFSGEEEQLCRKIRGAFANFIKNGNPTPGRIYDG--WLPYNKE---------NPFVYSL 533
                 |.::.||:...:::...:|||.:.|:|...|....  |.||...         .|.....
Human   561 -----RNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQYVSLDLRPLEVRR 620

  Fly   534 GEQAKT--------PQ----TGSVDEAE 549
            |.:|:.        |:    |.::||||
Human   621 GLRAQACAFWNRFLPKLLSATDTLDEAE 648

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12869	NP_001369085.1	COesterase	27..541	CDD:395084	153/599 (26%)
ACHE	NP_001354847.1	COesterase	104..630	CDD:395084	153/593 (26%)
		AChE_tetra	645..678	CDD:400834	4/4 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010