Protein Alignment CG12869 and Nlg4

DIOPT Version :10

• Sequence 1: NP_001369085.1
• Gene: CG12869 / 36616
• FlyBaseID: FBgn0033943
• Length: 839
• Species: Drosophila melanogaster
• Sequence 2: NP_001369025.1
• Gene: Nlg4 / 42402
• FlyBaseID: FBgn0083975
• Length: 1437
• Species: Drosophila melanogaster
• Alignment Length: 1221
• Identity: 257/1221 - (21%)
• Similarity: 398/1221 - (32%)
• Gaps: 471/1221 - (38%)

  Fly     9 QILRLLPILI---------HLSP------YISAQQTH--IKLEQGDLIGLKVFPDGTR--GAVYA 54
            |:|.||.:|:         |.:.      |..|:..|  ::...|.|.||.:..|..|  .:|..
  Fly     5 QLLLLLRLLLLPTVLISWMHCAGASTADIYKGARLGHRIVQTRYGRLHGLILPLDSFRFLRSVEV 69

  Fly    55 FLGIPYAQAPINELRFAPAKPSSSFNRTLQATTMQPLCPQLANTIYDESSD-GSMPRS------- 111
            |||:|||..|..:.||:|.:..:.::....:....|:|||....|.:|::. ..||:.
  Fly    70 FLGVPYATPPTKQNRFSPTRAPAPWDGIRISDKYSPVCPQRLPNIQNETAALEKMPKGRLEYLKR 134

  Fly   112 -----VSTDEDCLYLNIWTP-ESGMRYGKLPIVVIVTGEEFAYDWPR-NRINGLDLAGEG-IVVV 168
                 .:..|||||||:::| .:|....|||::|.:.||.|  :|.. |..:|..||..| :|||
  Fly   135 LLPFLENQSEDCLYLNVFSPVNAGANEKKLPVIVFIHGESF--EWSSGNPYDGSVLASYGEVVVV 197

  Fly   169 SVQYRNNIYGWLSLG---EQHRNVPGNYGLSDVQMALRWIRRNADAFGGNPDHITLLGHGSGGAP 230
            ::.||..|.|:|:..   ..|..| .||||.|...||.||::|...|||:|:.:||.|||:|.|.
  Fly   198 TLNYRLGILGFLNANPNPHAHARV-ANYGLMDQMAALHWIQQNIQKFGGDPNSVTLAGHGTGAAC 261

  Fly   231 LALVATLEDSSQVKQL----VLMSPGPIMRALGQNHQKWIVETGQV-----LVQKLGCQFEEAQR 286
            :..:.|  ..:.|:.|    :|||        |..:..|.:....|     |.:::.|...:...
  Fly   262 INYLMT--SPTMVRGLFHRAILMS--------GSAYSSWALVEDPVLFAIKLAKEVNCTIPDDIN 316

  Fly   287 R---QLMGCLRRKSREDLLRAYESVYNH--GNGSSQLGVILPEG---LPLEQRL-RNKTLPPVLL 342
            |   |::.|||....|||..|.....|.  ..|.|..||::..|   |.::..: ||........
  Fly   317 RHHEQIVDCLRDVPLEDLYLADIQAPNFLTSFGPSVDGVVIRPGHSNLDIDDLMARNSRRSSADS 381

  Fly   343 GITSNEG-------------------AFLQDYWLDVAREGQVALHKYINHTLLPNVMRALESVGE 388
            |..|:.|                   :|...|:   ...|...::...::.:|..|:.. ||:
  Fly   382 GFQSSAGGGGGQGGGAGGGGGGGSGSSFGGGYF---GGSGAGTMNMGGHYDVLFGVVTG-ESI-- 440

  Fly   389 ESSTQLAAIRWRYF-----NG-KGEGVSHLLAGMQR----------------------------- 418
                      ||:.     || :||....::....|
  Fly   441 ----------WRFSAHDIQNGFEGERRDKIIRTYVRNAYNYHLNEIFYTIVNEYTDWDRTSQHPI 495

  Fly   419 --------LLSESLYELPYSRILELL--------------------------NGTTS-----YAY 444
                    .||::.:..|..|..::|                          .|:|.     |.|
  Fly   496 NTRDTAVAALSDAQFVAPIVRAGDILAANSPPPVSSSSTAGSPGANAAASTSAGSTQPSGRCYFY 560

  Fly   445 VFDH-SHSMDMRGRRNLFGGASHSSDLPLLLGPSLFQQIAR--RRFSGEEEQLCRKIRGAFANFI 506
            |||: :...|...|.    |..|..|||.:.|..|....:.  :.::..|..|...:...:.||.
  Fly   561 VFDYQTKDGDYPQRM----GTVHGEDLPYIFGAPLVDGFSHFPQNYTKSETALSEAVMIFWTNFA 621

  Fly   507 KNGNPTPGRIYDGWLPYNKE--------------------------------------------- 526
            :.|||......|..||.:||
  Fly   622 RTGNPNEHHRQDSSLPVSKERNRFRSITWENYDPLHQKYLEIGMKPRIKNHFRAHQLSIWLRLIP 686

  Fly   527 --------------------------------NPFVYSLGEQAKTPQTGS--------VDEAEVD 551
                                            :||..|....|....:.|        |||..:.
  Fly   687 ELHRAGMEDVIARHNLFRNHDDMDLYEGPVKPDPFGISTAAGASGSSSSSSSSSRLLLVDEQLMM 751

  Fly   552 KLLRGETGAPGLDRSLSRSNRHDTYRAAPSNSYTASNQLDSGYSNHLQMVYGFWQVLMPLEREED 616
            |..||..|:..|:..|..:.      ..|:|.||....:...||:
  Fly   752 KKGRGLNGSAYLNGILGVTT------VEPNNMYTTCIPIGGNYSS-------------------- 790

  Fly   617 LRGGGALGQRVRLLEASAD--AARYRQGFYA----------MLGLVCLLLACLCLCVYLLKRDPN 669
              .||.... ..|..||:|  |:.:....||          .:|...|:|..|.......:||..
  Fly   791 --SGGVFAP-TTLANASSDTLASGFEAAGYAAYSTALSVTIAIGCSLLILNVLIFAGVYYQRDKT 852

  Fly   670 AMRRRSASSASDCYSLXHKWFRWTTIFGGRKDEVP------------------STSGIANVESWR 716
            .:..::........|| |:             :||                  |.:.|.:|||.:
  Fly   853 RLEVKTLQKQYQQRSL-HQ-------------QVPYPPEPIKHAHYHMGHSQSSANVIVDVESHQ 903

  Fly   717 -KGGRAT-------------------------------KREQDGSGAVESGG--GDGNLEG---- 743
             :.|:|.                               :::|.|.|   |||  .:|.:||
  Fly   904 DQAGQAAMLLQAAAAAAAAAANDVKPPPPHICSNTGMQQQQQVGGG---SGGALNNGGIEGSKVT 965

  Fly   744 -------------ERREQVLNKQRTRRPRQLQPYDFKITHPIG----GAGVGAGFGTGTAGG--- 788
                         ::::|...:|:.::...:|......|...|    |:|.|||.|.|:|.|
  Fly   966 TDNLGNVTYSTSSKQQQQHQQQQQQQQREHMQIKGMTGTQTFGRSGSGSGGGAGGGAGSASGGAS 1030

  Fly   789 -------------------------------VRN-------GGGT-------------------R 796
                                           .||       ||||                   .
  Fly  1031 VVVSGSSVSYNPGMMTLPKSGGLHHAATLNYARNTTALNMSGGGTALVDSRGNVLLTSTAVGPGM 1095

  Fly   797 AGTVSGFGGTLG--------TVEELLD-PVAGQFEPSVAVRNWQYQLTCDK 838
            |||.:| ||:.|        |:...|. ..||:..|:..::.:|.|....|
  Fly  1096 AGTGAG-GGSSGGGGGGDCMTLPRNLGLAAAGRHNPTTELQQYQQQQQSSK 1145

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12869	NP_001369085.1	COesterase	27..541	CDD:395084	162/727 (22%)
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	157/670 (23%)