DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12869 and Gli

DIOPT Version :9

Sequence 1:	NP_001369085.1	Gene:	CG12869 / 36616	FlyBaseID:	FBgn0033943	Length:	839	Species:	Drosophila melanogaster
Sequence 2:	NP_476602.1	Gene:	Gli / 34927	FlyBaseID:	FBgn0001987	Length:	956	Species:	Drosophila melanogaster

Alignment Length:	581	Identity:	155/581 - (26%)
Similarity:	231/581 - (39%)	Gaps:	143/581 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 GDLIGLKVF-----------------PDGTRGAVYAFLGIPYAQAPINELRFAPAKPSSSFNRTL 83
            |.:.|.||:                 .|...|....|||||||..|..|.||.|.:....: :.|
  Fly   142 GQVQGFKVYMYDNPDPKSFYRPYHSTVDRVMGECSVFLGIPYALPPTFEGRFKPPRVHRGW-QLL 205

  Fly    84 QATTMQPLCPQLANTIYDESSDGSMPRSVSTDEDCLYLNIWTPESGMRYG-KLPIVVIVTGEEFA 147
            ||....|.|||...  |..::.|.|    ..||||||||:::|::|.... |.|::|.:.|.||.
  Fly   206 QAVDFGPACPQPVR--YTGATKGIM----DMDEDCLYLNVYSPKTGAGVAQKYPVMVYIHGGEFI 264

  Fly   148 YDWPRNRINGLDLAG-EGIVVVSVQYRNNIYGWLSLGEQHRNVPGNYGLSDVQMALRWIRRNADA 211
            .. ..|...|..||. ..:|||::.||....|:||.|::  |.|||||:.|..|||||:..|.:.
  Fly   265 RG-ASNLFQGHILASFYDVVVVTLNYRLGALGFLSTGDE--NSPGNYGILDQAMALRWVYDNIEF 326

  Fly   212 FGGNPDHITLLGHGSGGAPLALVATLEDSSQVKQLVLMSPGPIMRALGQNHQKWIVE-TGQVLVQ 275
            |.|:.:.|||.|.|:|||...|:.....:..:.:.|:...|..:........|:..: |.:||.|
  Fly   327 FNGDRNSITLFGPGAGGASAGLLMVAPQTRNIVRRVIAQSGSALADWALIQDKYRAQNTSRVLGQ 391

  Fly   276 KLGCQFEEAQRRQLMGCLRRKSREDLLRAYESVYNHGN-------GSSQLGVILPEGLPL----- 328
            .|||..|.:.:  |:.|         ||...|.|..||       ||...|.:|.....|
  Fly   392 LLGCSIESSWK--LVNC---------LRTGRSFYELGNAEFSPQVGSFPWGPVLDHNFTLPGDDW 445

  Fly   329 -----EQRLRNKTLPPVLL--------------GITSNEGAF-------LQDYWLDVAREGQVAL 367
                 |:..|..|..|..|              |:|:.|.||       |..|:....|.....:
  Fly   446 YEGWREKDWRFLTQTPETLIRAGKFNRNIQYMTGVTTQEAAFFVAQNESLSPYYELDGRFFDQKI 510

  Fly   368 HKYI---NHTLLPN-VMRALESV-----GEESSTQLAAIRWRYFNGKGEGVSHLLAGMQRLLSES 423
            .:::   |:||.|| |..|::.:     ...::|   .||.:|.|               :||:.
  Fly   511 REHVFRYNYTLNPNGVYEAIKYIYTFWPDPNNNT---IIRDQYIN---------------MLSDL 557

  Fly   424 LYELPYSRILELL--NGTTSYAYVFD-------------HSHSMDMRGRRNLFGGASHSSDLPLL 473
            .|..|..::::|:  .....|.||.:             :.|.::    |....||.       .
  Fly   558 YYRAPVDQMVKLMLEQKVPVYMYVLNTTVEALNLPQWRKYPHDIE----RYFLTGAP-------F 611

  Fly   474 LGPSLF---QQIARRRFSGEEEQLCRKIRGAFANFIKNGNPTP--------GRIYDGWLPY 523
            :....|   :.:.|..::..:..:.......:.||.:.|||||        .|.|.|.:.|
  Fly   612 MDTEFFPKKEHLQRNMWTDNDRNMSHFFMQTYTNFARYGNPTPQQVLGMHFQRAYQGEIRY 672

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12869	NP_001369085.1	COesterase	27..541	CDD:395084	155/581 (27%)
Gli	NP_476602.1	COesterase	134..695	CDD:278561	155/581 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810