DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12869 and CG6414

DIOPT Version :9

Sequence 1:	NP_001369085.1	Gene:	CG12869 / 36616	FlyBaseID:	FBgn0033943	Length:	839	Species:	Drosophila melanogaster
Sequence 2:	NP_001303565.1	Gene:	CG6414 / 31352	FlyBaseID:	FBgn0029690	Length:	583	Species:	Drosophila melanogaster

Alignment Length:	555	Identity:	151/555 - (27%)
Similarity:	227/555 - (40%)	Gaps:	82/555 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LLPILIHLSPYISAQQTHIKLEQGD-LIGLKVFPDGTRGAVYAFLGIPYAQAPINELRFAPAKPS 76
            ||.|.|..|...::|..|::|..|. |||..:.....| .:.||:|:|||:.|:::|||.|..|.
  Fly    14 LLCICIQWSDGRNSQCLHVRLSHGGWLIGRHLTTHNGR-HMRAFMGVPYAEPPLDDLRFRPPVPK 77

  Fly    77 SSFNRTLQATTMQPLCPQLANTIYDESSDGSMPRSVSTDEDCLYLNIWTPESGMRYGKLPIVVIV 141
            :.:.....|....|:|.|......|...:||        |||||||::|||.....|.||::|..
  Fly    78 APWEGERLAIKDAPICLQRDPFRRDMILEGS--------EDCLYLNVYTPERPRTNGSLPVMVWF 134

  Fly   142 TGEEFAYDWPRNRINGLD-LAGEGIVVVSVQYRNNIYGWLSLGEQHRNVPGNYGLSDVQMALRWI 205
            .|..:......:...|.| |....||:||..:|....|:||  .:..:.|||.||.|....|.|:
  Fly   135 HGGGWQCGSGISSFYGPDFLLDHDIVLVSANFRLGPLGFLS--TETLDCPGNNGLKDQLEVLHWV 197

  Fly   206 RRNADAFGGNPDHITLLGHGSGGAPLALVATLEDSSQVKQLVLMSPGPIMRALGQNHQKWIVETG 270
            |.|..:|||:|:.:|:.|..:|||.:......|.|..:....:...|.......|...|. |..|
  Fly   198 RANIASFGGDPNSVTVFGESAGGASVTYHMLSEKSRGLLHRGIAQSGTYFNPWAQPAHKG-VAAG 261

  Fly   271 QV--LVQKLGCQFEEAQRRQLMGCLRRKSREDLLRAYESVY----------------NHGNGSSQ 317
            :.  |.|.:||. ...:..:.:.|||:|..||::.:...::                .|.
  Fly   262 RATKLAQIVGCG-NAGEWPEKLECLRKKPAEDIVASLYDMFVWDFDPMIPFPPVVEPEHD----- 320

  Fly   318 LGVIL---------PEGLPLEQRLRNKTLPPVLLGITSNEGAFLQDYWLDVAREGQVALHKYINH 373
             |..|         |.||.|          |:::|.|:.||.......|::.:  .:|..|....
  Fly   321 -GAFLTVAPRQAAKPHGLQL----------PLMVGATAEEGLLKTAALLNLPQ--LLAEFKSQFE 372

  Fly   374 TLLPNVMRALESVGEESSTQLAAIRWRYFNGKGEGVSHLLAGMQR---LLSESLYELPYSRILEL 435
            .:||.|:...........|....|...||.   .|..:..|..|.   |:|:..:.......|.|
  Fly   373 QVLPVVLNYDHHDDSVRQTITQRIESFYFK---SGHDYDKANHQNLTDLISDGWFVAGIDEYLRL 434

  Fly   436 L----NGTTSYAYVFDH----SHSMDMRGRRNLFGGASHSSDLPLL--LGPSLFQQIARRRFSGE 490
            .    :...:|.|:|||    |.:...:|.||.|.||.|:.:|..|  :|..||......:...|
  Fly   435 RMSQEDVAPTYVYLFDHKGAASFTEIFKGGRNEFYGACHAEELQYLFPIGRELFVSAVPTQKDLE 499

  Fly   491 EEQLCRKIRGAFANFIKNGNPTPGRI---YDGWLP 522
            ..:|...:   :.:|.|.|||.|..:   ...|.|
  Fly   500 LRELMLHL---WVSFAKTGNPNPTNVSFHLPNWSP 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12869	NP_001369085.1	COesterase	27..541	CDD:395084	146/541 (27%)
CG6414	NP_001303565.1	COesterase	36..567	CDD:278561	143/533 (27%)
CG6414	NP_001303565.1	Aes	<116..>254	CDD:223730	42/139 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910