DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12869 and cest-9.2

DIOPT Version :9

Sequence 1:	NP_001369085.1	Gene:	CG12869 / 36616	FlyBaseID:	FBgn0033943	Length:	839	Species:	Drosophila melanogaster
Sequence 2:	NP_741910.3	Gene:	cest-9.2 / 259729	WormBaseID:	WBGene00007695	Length:	617	Species:	Caenorhabditis elegans

Alignment Length:	771	Identity:	158/771 - (20%)
Similarity:	275/771 - (35%)	Gaps:	244/771 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LIHLSPYISAQQTHIKLEQGDLIGLKVFPDGTRGAVYAFLGIPYAQAPINELRFAPAKPSSSFNR 81
            ||.|.|.|.:.:. |:...|.:.|:..:.|..... |.|..:|:|:.||.:|||||.:...|::.
Worm    11 LILLFPDIQSLKV-IETSYGRVRGITEWSDDNNHK-YMFKSVPFAKPPIGKLRFAPPQYPDSWSG 73

  Fly    82 TLQATTMQPLCPQLANTIYDESSDGSMPRSVSTDEDCLYLNIWTPESGMRYGKLPIVVIVTGEEF 146
            .|.|:...|.|  |:|     ||..|.|:. ...|||||:||:|.|..:| .|..::|...|..:
Worm    74 VLDASKYSPAC--LSN-----SSTTSTPQE-HVSEDCLYINIFTSEKCLR-SKCAVIVYFHGGAY 129

  Fly   147 AYD----WPRNRINGLDLAGEGIVVVSVQYRNNIYGWLSLGEQHRNVPGNYGLSDVQMALRWIRR 207
            ..|    :|.|.|....:| |.:::.....|..::|.|..|.. ..:..|..:.|...||.::..
Worm   130 NGDSATMFPDNFILERYVA-EDVILAIPGVRLGVFGQLYFGPS-ALLTENLFMFDAVQALDFVHN 192

  Fly   208 NADAFGGNPDHITLLGHGSGGAPLALVATLEDSSQV-------KQLVLMSPGPIMRALGQNHQKW 265
            ....|||:|..:|::||.|||   .||..|..|:.|       :|::::|...:.     .....
Worm   193 EIPNFGGDPKQVTIMGHSSGG---TLVEALGFSNSVDPDLKLFQQIIVLSGTGMF-----GFYDL 249

  Fly   266 IVETGQVLVQKLGC------QFEEAQRRQLMGCLRRKSREDLL---RAYESVYNHGNGSSQLGVI 321
            :|:...::.:||||      :..:|...:::.|:|:....:::   :..|.||.....|...|..
Worm   250 LVDNSFIISEKLGCFNGTQEERTDANIAEILECMRQIDGHEIVGMQKHMEDVYKLTFKSLLRGAP 314

  Fly   322 LPEGLPLEQRLRNKTLP-PVLLGITSNE-------GAFLQDYWLDVAREGQVALHKYINHTLLPN 378
            ..|.....::.||.|.| ..:.|.|..|       ..::...:||.  |..||:.::.:..|:.|
Worm   315 FMELNGKIEKFRNSTSPRNAIFGTTEYEFRNEVERYLYITTTFLDF--ENPVAVAQHFDDELMQN 377

  Fly   379 VMRALESVGEESSTQLAAIRWRYFNGKGEGVSHLLAGMQRLLSES-----LYELPYSRILELLNG 438
            :           .|.:        ||....:....|.....::.:     |:|
Worm   378 M-----------DTMI--------NGDAVSIFVSAAAFSSAMANAGADVYLFE------------ 411

  Fly   439 TTSYAYVFDHSHSMDMRGRRNLFGGASHSSDLPLLLGPSLFQQIARRRFSGEEEQLCRKIRGAFA 503
            |..:.|.|   |..||:....:.....|:.|:.:|  .|.:.::                   ..
Worm   412 TRQWPYSF---HVSDMQYFIGIHREVLHTHDMDIL--DSFYSKL-------------------LV 452

  Fly   504 NFIKNGNPTP---------------------GR---IYDGWLPYNKENPFVYSLGEQAKTPQTGS 544
            ||.|.|.|:|                     |:   :.:|:  ::||..|.|.
Worm   453 NFTKTGAPSPEWNSLEPEKMNYLELRVDTRNGKGPVMLEGY--HDKEVSFWYG------------ 503

  Fly   545 VDEAEVDK---LLRGETGAP----GLDRSLS--------RSNRHDTYRAAPSNSYTASNQLDSG- 593
             |..:.|:   .:|...|.|    |::..|.        |:..| ...|...|..|::|.|.:.
Worm   504 -DMMDYDRNITKMRQSKGLPRENQGVESQLKYWSSIVEPRTTAH-ANNATQENISTSTNVLFTST 566

  Fly   594 -------YSNHLQMVYGFWQVLMPLEREEDLRGGGALGQRVRLLEASADAARYRQGFYAMLGLVC 651
                   :.|...::..:|                                     ||.::.||.
Worm   567 AQYISREFKNSTPILQQWW-------------------------------------FYLIIALVV 594

  Fly   652 LLLACLCLCVYLLKRDPNAMRRRSASSASDCYSLXHKWFRWTTIFGGRKDEVPSTS 707
            ::.    :.:::..|.|.                             |::|||..|
Worm   595 MIF----VLIFISLRKPR-----------------------------REEEVPLLS 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12869	NP_001369085.1	COesterase	27..541	CDD:395084	126/570 (22%)
cest-9.2	NP_741910.3	Abhydrolase	19..501	CDD:304388	124/561 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900