DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12869 and Ces2a

DIOPT Version :9

Sequence 1:	NP_001369085.1	Gene:	CG12869 / 36616	FlyBaseID:	FBgn0033943	Length:	839	Species:	Drosophila melanogaster
Sequence 2:	NP_653344.1	Gene:	Ces2a / 246252	RGDID:	708353	Length:	558	Species:	Rattus norvegicus

Alignment Length:	546	Identity:	147/546 - (26%)
Similarity:	232/546 - (42%)	Gaps:	110/546 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LLPILIHLSPYISA---QQTHIKLEQGDLIGLKVFPDGTRGAVYAFLGIPYAQAPINELRFAPAK 74
            ||.:|.|:....||   :.||....:|..:.:|    .|:..::.|||||:|:.|:..|||||.:
  Rat    17 LLLLLQHVHGQDSASPIRNTHTGQVRGSFVHVK----DTKSGIHTFLGIPFAKPPVGPLRFAPPE 77

  Fly    75 PSSSFNRTLQATTMQPLCPQLANTIYDESSDGSM---PRSVSTDEDCLYLNIWTPESGMRYGKLP 136
            ....::....||:...:|.|......|...:..:   |..:|  ||||||||:||........||
  Rat    78 DPEPWSGVRDATSQPAMCLQTDIMNLDGIKEMKLTVHPTPMS--EDCLYLNIYTPAHAREGSNLP 140

  Fly   137 IVVIVTGEEFAYDWPRNRINGLDL------------AGEGIVVVSVQYRNNIYGWLSLGEQHRNV 189
            ::|.:.|            .||.|            |.|.||:||:|||..:.|:.|.|:|  |.
  Rat   141 VMVWIHG------------GGLVLGSASMNDASTLAATEEIVIVSIQYRLGVLGFFSTGDQ--NA 191

  Fly   190 PGNYGLSDVQMALRWIRRNADAFGGNPDHITLLGHGSGGAPLALVATLEDSSQVKQLVLMSPGPI 254
            .||:|..|...||||:::|...||||...:|:.|..:||..:        ||.|  :..||.|..
  Rat   192 RGNWGYLDQVAALRWVQQNIAYFGGNHGKVTIFGGSAGGTSV--------SSHV--VSPMSKGLF 246

  Fly   255 MRALGQNHQKWIVETGQVLVQKL----------------GCQFEEAQRRQLMGCLRRKSREDLLR 303
            ..|        |:::|..|:..|                ||:..:::  .|:.|||.||::::|
  Rat   247 HGA--------IMQSGVALLPDLISDKSEVVYKTVANLSGCEAPDSE--ALIRCLRAKSKQEIL- 300

  Fly   304 AYESVYNHGNGSSQLGVILPEGLPLEQRLRNKTLP-PVLLGITSNEGAFLQDYWLDVAREGQVAL 367
            |...|:....|... |..||:. |.|........| |.::||.::|..:....:|     |...:
  Rat   301 AINQVFKMIPGVVD-GKFLPKH-PQELLASGDFHPVPSIIGINTDECGWGIPVFL-----GLDHI 358

  Fly   368 HKYINHTLLPNVMRA-----------LESVGEESSTQLAAIRWRYFNGKGEGVSHLLAGMQRLLS 421
            .|.|....||.|:::           ::.:.||            :.|..|....|....:.:|.
  Rat   359 IKKITRETLPTVLKSTAAQMMLPPECIDLIMEE------------YMGDTENPETLQEQFRHMLG 411

  Fly   422 ESLYELPYSRILELLNGTTS-YAYVFDHSHSMDMRGRRNLFGGASHSSDLPLLLGPSLFQQIARR 485
            :.::.:|..::......... |.|.|.|..|. ::..|.....|.|..|:..:.|..|:....
  Rat   412 DFMFVIPALQVAHFQRSQAPVYFYEFQHLPSF-IKQVRPSHVKADHGDDILFVFGSYLWGMTF-- 473

  Fly   486 RFSGEEEQLCRKIRGAFANFIKNGNP 511
            ..:.|||.|.|::...:|||.:.|||
  Rat   474 DLTEEEELLKRRVMKYWANFARTGNP 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12869	NP_001369085.1	COesterase	27..541	CDD:395084	141/529 (27%)
Ces2a	NP_653344.1	COesterase	30..537	CDD:395084	142/533 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D233524at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020