DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12869 and Nlgn3

DIOPT Version :9

Sequence 1:	NP_001369085.1	Gene:	CG12869 / 36616	FlyBaseID:	FBgn0033943	Length:	839	Species:	Drosophila melanogaster
Sequence 2:	NP_766520.2	Gene:	Nlgn3 / 245537	MGIID:	2444609	Length:	825	Species:	Mus musculus

Alignment Length:	755	Identity:	177/755 - (23%)
Similarity:	284/755 - (37%)	Gaps:	191/755 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LRLLPILIHLSPYISAQ--QTHIKLEQGDLIGLKV-FPDGTRGAVYAFLGIPYAQAPINELRFAP 72
            |..|.:::..|....|.  .||.    |.|.|.:| .|....|.|..:||:|||..||.|.||.|
Mouse    23 LGFLSLVLRASTQAPAPTVNTHF----GKLRGARVPLPSEILGPVDQYLGVPYAAPPIGEKRFLP 83

  Fly    73 AKPSSSFNRTLQATTMQPLCPQLANTIYDE---------SSDGSMPRSVSTDEDCLYLNIWTPE- 127
            .:|..|::....||...|:|||..:|...|         :.|.........:|||||||::.|.
Mouse    84 PEPPPSWSGIRNATHFPPVCPQNIHTAVPEVMLPVWFTANLDIVATYIQEPNEDCLYLNVYVPTE 148

  Fly   128 --SGMR-------------------YGKLPIVVIVTGEEFAYDWPRNRINGLDLAGEG-IVVVSV 170
              ||.:                   .|..|::|.:.|..: .:...|.|:|..||..| ::|:::
Mouse   149 DGSGAKKQGEDLADNDGDEDEDIRDSGAKPVMVYIHGGSY-MEGTGNMIDGSVLASYGNVIVITL 212

  Fly   171 QYRNNIYGWLSLGEQHRNVPGNYGLSDVQMALRWIRRNADAFGGNPDHITLLGHGSGGAPLALVA 235
            .||..:.|:||.|:|  ...|||||.|...||||:..|...|||:|..||:.|.|.|.:.::|:.
Mouse   213 NYRVGVLGFLSTGDQ--AAKGNYGLLDQIQALRWVSENIAFFGGDPRRITVFGSGIGASCVSLLT 275

  Fly   236 TLEDSSQVKQLVLMSPGPIMRALGQNHQKWIVETGQVLVQKLGCQFEEAQRRQLMGCLRRKSRED 300
            ....|..:.|..::..|..:.:...|:|.  |:...:|..|:||...:..  .::.|||:||.::
Mouse   276 LSHHSEGLFQRAIIQSGSALSSWAVNYQP--VKYTSLLADKVGCNVLDTV--DMVDCLRQKSAKE 336

  Fly   301 LLR--AYESVYNHGNGSSQLGVILPEGLPLEQRLRNKTLPPVLLGITSNEGAFLQ-DYWLDVAR- 361
            |:.  ...:.|:...|....|.::|:.            |.:|:    .:|.||. |..|.|.:
Mouse   337 LVEQDIQPARYHVAFGPVIDGDVIPDD------------PEILM----EQGEFLNYDIMLGVNQG 385

  Fly   362 ------EGQVALHKYINHT----LLPNVMRALESVGEESSTQLAAIRWRYFN-GKGEGVSHLLAG 415
                  ||.|.....::.|    .:.|.:..|....|...|....|::.|.: ...:........
Mouse   386 EGLKFVEGVVDPEDGVSGTDFDYSVSNFVDNLYGYPEGKDTLRETIKFMYTDWADRDNPETRRKT 450

  Fly   416 MQRLLSESLYELP--YSRILELLNGTTSYAYVFDHSHSMDMRGRRNLFGGASHSSDLPL-----L 473
            :..|.::..:..|  .:..|....|:.:|.|.|.| |...:  .:..:..|:|..::|.     :
Mouse   451 LVALFTDHQWVEPSVVTADLHARYGSPTYFYAFYH-HCQSL--MKPAWSDAAHGDEVPYVFGVPM 512

  Fly   474 LGPS-LFQQIARRRFSGEEEQLCRKIRGAFANFIKNGNP------------TPGRIYD--GWLPY 523
            :||: ||.    ..||..:..|...:...:.||.|.|:|            |....::  .|..|
Mouse   513 VGPTDLFP----CNFSKNDVMLSAVVMTYWTNFAKTGDPNKPVPQDTKFIHTKANRFEEVAWSKY 573

  Fly   524 NKEN----------------------------PFVYSLGEQ-------AKTPQTGSVDEAEVDKL 553
            |..:                            |.:|:|.:.       .|.|...:...:.:.:.
Mouse   574 NPRDQLYLHIGLKPRVRDHYRATKVAFWKHLVPHLYNLHDMFHYTSTTTKVPPPDTTHSSHITRR 638

  Fly   554 LRGETGAPGLDRSLSRSNRHDTYRAAPSNSYTASN-------QLDSG---------YSNHLQMVY 602
            ..|:|.:              |.|.|.|.:|:..|       ..|:|         ||..|.:..
Mouse   639 PNGKTWS--------------TKRPAISPAYSNENAPGSWNGDQDAGPLLVENPRDYSTELSVTI 689

  Fly   603 G------FWQVLM--------------PLEREEDLRGGGA 622
            .      |..||.              ||.:....||.||
Mouse   690 AVGASLLFLNVLAFAALYYRKDKRRQEPLRQPSPQRGTGA 729

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12869	NP_001369085.1	COesterase	27..541	CDD:395084	150/620 (24%)
Nlgn3	NP_766520.2	COesterase	39..601	CDD:365897	146/595 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	151..172		2/20 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	622..668		10/59 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810