Protein Alignment CG12869 and Ces1a

DIOPT Version :10

• Sequence 1: NP_001369085.1
• Gene: CG12869 / 36616
• FlyBaseID: FBgn0033943
• Length: 839
• Species: Drosophila melanogaster
• Sequence 2: NP_001013786.2
• Gene: Ces1a / 244595
• MGIID: 3648919
• Length: 563
• Species: Mus musculus
• Alignment Length: 616
• Identity: 164/616 - (26%)
• Similarity: 257/616 - (41%)
• Gaps: 140/616 - (22%)

  Fly     1 MWNALRIQQILRLLPILIHLS--PYISAQQTHIKLEQGDLIGLKVFPDGTRGAVYAFLGIPYAQA 63
            ||........|.....|.|||  |.:...       ||.::|..:..:|:...|..|||:|:|:.
Mouse     1 MWLFALALASLNTCMALGHLSSPPVVDTL-------QGKVMGKYISLEGSAQPVAVFLGVPFAKP 58

  Fly    64 PINELRFAPAKPSSSFNRTLQATTMQPLCPQLANTIYDESSDGSMPRSVSTD----------EDC 118
            |:..|||||.:|:.:::.....|:..|:|.|:...       |.:...|.|:          |||
Mouse    59 PLGPLRFAPPQPAETWSSVKNTTSYPPMCSQITGV-------GPVLSDVFTNQLENVPLEYSEDC 116

  Fly   119 LYLNIWTPESGMRYGKLPIVV------IVTGEEFAYDWPRNRINGLDLA-GEGIVVVSVQYRNNI 176
            |||||::|.......:||::|      :::|....:|       ||.|: .|.:|:|.:|||..|
Mouse   117 LYLNIYSPTDLTSKDRLPVMVWVHGGGLLSGGASTFD-------GLALSTHENVVIVVIQYRLGI 174

  Fly   177 YGWLSLGEQHRNVPGNYGLSDVQMALRWIRRNADAFGGNPDHITLLGHGSGGAPLALVATLEDSS 241
            :|:||.|::|..  ||:|..|...||:|::.|...|||:|..:||.|..:||            .
Mouse   175 WGFLSTGDEHSR--GNWGHLDQVAALQWVQNNIANFGGDPSSVTLFGESAGG------------E 225

  Fly   242 QVKQLVLMSPGPIMRALGQNHQKWIVETGQVLVQKLGCQFEEAQRR-----------------QL 289
            .|..|||   .|:.:.|   .|:.|.|:|..|..   |.|.|..||                 .:
Mouse   226 SVSVLVL---SPLTKNL---FQRAISESGVALTP---CLFRETTRRAAEQVAIATGCVATTSADI 281

  Fly   290 MGCLRRKSREDLLR--------AYESVYNHGNGSSQL-----GVILPEGLPLEQRLRNKTL--PP 339
            :.|||.|:.|:||.        |.:.:.:.......|     ||:||:. | |:.|..|:.  .|
Mouse   282 VHCLREKTEEELLATTLKMKFFALDLLGDPRESYPFLTTVIDGVVLPKA-P-EEILAEKSFNTVP 344

  Fly   340 VLLGITSNE-GAF---LQDYWLDVAREGQVALHKYINHTL-LPNVMRALESVGEESSTQLAAIRW 399
            .::||...| |.|   :..|.|...:..|.:....:..:. |.|:.:.|..|..|
Mouse   345 YIVGINKQEFGWFIPMMMGYPLSEGKLDQKSATSLLWKSYPLTNISKELTPVATE---------- 399

  Fly   400 RYFNGKG--EGVSHLLAGMQRLLSESLYELP------YSRILELLNGTTSYAYVFDHSHSM--DM 454
            :|..|..  :....|...|   :.:.|:.:|      |.|..    |..:|.|.|.:..|.  ||
Mouse   400 KYLGGSDCPDKKKDLFLDM---MGDVLFAVPSVIVARYHRDA----GAPTYMYEFKYHPSFVSDM 457

  Fly   455 RGRRNLFGGASHSSDLPLLLGPSLFQQIARRRFSGEEEQLCRKIRGAFANFIKNGNPTPGRIYDG 519
            |.:..:   |.|..::..:.|....::.|    |.||..|...:...:.||.:||||. |.....
Mouse   458 RPKTVI---ADHGDEVYSVWGTPFLKEGA----SEEEINLSTMMMKFWGNFARNGNPN-GEGLPH 514

  Fly   520 WLPYNKENPFVYSLGEQAKTPQTGSVDEAEV 550
            |..|.::..:: .:|  |.|.|...:.:.||
Mouse   515 WPEYGEKESYL-QIG--ATTQQAQRLKDKEV 542

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12869	NP_001369085.1	COesterase	27..541	CDD:395084	153/577 (27%)
Ces1a	NP_001013786.2	COesterase	22..545	CDD:395084	157/595 (26%)