DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12869 and Ces2c

DIOPT Version :9

Sequence 1:	NP_001369085.1	Gene:	CG12869 / 36616	FlyBaseID:	FBgn0033943	Length:	839	Species:	Drosophila melanogaster
Sequence 2:	NP_663578.1	Gene:	Ces2c / 234671	MGIID:	2385905	Length:	561	Species:	Mus musculus

Alignment Length:	557	Identity:	156/557 - (28%)
Similarity:	250/557 - (44%)	Gaps:	110/557 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LLPILIHL----SPYIS-AQQTHIKLEQGDLIGLKVFPDGTRGAVYAFLGIPYAQAPINELRFAP 72
            ||.:|||:    ||..: .:.||....||.||.:|    .|:..|:.|||||:|:.|:..|||||
Mouse    17 LLLLLIHVQGQDSPEANPIRNTHTGQIQGSLIHVK----DTKAGVHTFLGIPFAKPPVGPLRFAP 77

  Fly    73 AKPSSSFNRTLQATTMQPLCPQLANTIYDESSDGSMP------RSVSTDEDCLYLNIWTPESGMR 131
            .:....::.....|....:|  |.|  .|..::..:|      .|....||||||||:||.....
Mouse    78 PEAPEPWSGVRDGTAHPAMC--LQN--LDMLNEAGLPDMKMMLSSFPMSEDCLYLNIYTPAHAHE 138

  Fly   132 YGKLPIVV------IVTGEEFAYDWPRNRINGLDLAGEGIVVVSVQYRNNIYGWLSLGEQHRNVP 190
            ...||::|      :|.|....:|.....:|      |.:|||::|||..:.|:.|.|:||..
Mouse   139 GSNLPVMVWIHGGALVIGMASMFDGSLLTVN------EDLVVVTIQYRLGVLGFFSTGDQHAR-- 195

  Fly   191 GNYGLSDVQMALRWIRRNADAFGGNPDHITLLGHGSGGAPLALVATLEDSSQVKQLVLMSP---- 251
            ||:|..|...||||:::|...||||||.:|:.|..:||..:        ||.|     :||
Mouse   196 GNWGYLDQAAALRWVQQNIAHFGGNPDRVTIFGESAGGTSV--------SSHV-----VSPMSQG 247

  Fly   252 ---GPIMRALGQNHQKWIVETGQVL---VQKL-GCQFEEAQRRQLMGCLRRKSREDLLRAYESVY 309
               |.||.:........|.||.:::   |.|| ||:..::|  .|:.|||.||..::| |...|:
Mouse   248 LFHGAIMESGVALLPDLISETSEMVSTTVAKLSGCEAMDSQ--ALVRCLRGKSEAEIL-AINKVF 309

  Fly   310 NHGNGSSQLGVILP-----EGLPL--EQRLRNKTLPPV--LLGITSNEGAFLQDYWLDVAREGQV 365
            .          ::|     |..|.  ::.|.::...||  ::|:.::|..     |......|..
Mouse   310 K----------MIPAVVDGEFFPRHPKELLASEDFHPVPSIIGVNNDEFG-----WSIPVVMGSA 359

  Fly   366 ALHKYINHTLLPNVMRALESVGEESSTQL------AAIRWRYFNGKGEGVSHLLAGMQRLLSESL 424
            .:.|.|..       ..|::|.::::.|:      :.:....:.|..|....|......::.:.:
Mouse   360 QMIKGITR-------ENLQAVLKDTAVQMMLPPECSDLLMEEYMGDTEDAQTLQIQFTEMMGDFM 417

  Fly   425 YELPYSRILELLNG-TTSYAYVFDH--SHSMDMRGRRNLFGGASHSSDLPLLLGPSLFQQIARRR 486
            :.:|..::...... ...|.|.|.|  |:..|:|...   ..|.|:.::|.:.. |.|..: :..
Mouse   418 FVIPALQVAHFQRSHAPVYFYEFQHPPSYFKDVRPPH---VKADHADEIPFVFA-SFFWGM-KLD 477

  Fly   487 FSGEEEQLCRKIRGAFANFIKNGNPTPGRIYDGWLPY 523
            |:.|||.|.|::...:|||.::|||..    :| |||
Mouse   478 FTEEEELLSRRMMKYWANFARHGNPNS----EG-LPY 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12869	NP_001369085.1	COesterase	27..541	CDD:395084	149/538 (28%)
Ces2c	NP_663578.1	COesterase	31..540	CDD:278561	149/543 (27%)
		Aes	<130..>233	CDD:223730	39/110 (35%)
		Prevents secretion from ER. /evidence=ECO:0000255	558..561
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D233524at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920