Protein Alignment CG12869 and NLGN1

DIOPT Version :10

• Sequence 1: NP_001369085.1
• Gene: CG12869 / 36616
• FlyBaseID: FBgn0033943
• Length: 839
• Species: Drosophila melanogaster
• Sequence 2: NP_001352852.1
• Gene: NLGN1 / 22871
• HGNCID: 14291
• Length: 843
• Species: Homo sapiens
• Alignment Length: 745
• Identity: 168/745 - (22%)
• Similarity: 284/745 - (38%)
• Gaps: 182/745 - (24%)

  Fly    50 GAVYAFLGIPYAQAPINELRFAPAKPSSSFNRTLQATTMQPLCPQLANTIYDESSDGSMPRSV-- 112
            |.|..|||:|||..|..|.||.|.:|.|.::....||...|:|||  |.|     ||.:|..:
Human    75 GPVIQFLGVPYAAPPTGERRFQPPEPPSPWSDIRNATQFAPVCPQ--NII-----DGRLPEVMLP 132

  Fly   113 ---------------STDEDCLYLNIWTP--------------------------ESGMRYGKLP 136
                           ...||||||||:.|                          :||   |..|
Human   133 VWFTNNLDVVSSYVQDQSEDCLYLNIYVPTEDGPLTKKQTDDLGDNDGAEDEDIRDSG---GPKP 194

  Fly   137 IVVIVTGEEFAYDWPRNRINGLDLAGEG-IVVVSVQYRNNIYGWLSLGEQHRNVPGNYGLSDVQM 200
            ::|.:.|..: .:...|..:|..||..| ::|::|.||..:.|:||.|:|  ...|||||.|:..
Human   195 VMVYIHGGSY-MEGTGNLYDGSVLASYGNVIVITVNYRLGVLGFLSTGDQ--AAKGNYGLLDLIQ 256

  Fly   201 ALRWIRRNADAFGGNPDHITLLGHGSGGAPLALVATLEDSSQVKQLVLMSPGPIMRALGQNH--- 262
            ||||...|...|||:|..||:.|.|:||:.:.|: ||...|:..:....:.|...||:.|:.
Human   257 ALRWTSENIGFFGGDPLRITVFGSGAGGSCVNLL-TLSHYSEGNRWSNSTKGLFQRAIAQSGTAL 320

  Fly   263 QKWIV-----ETGQVLVQKLGCQFEEAQRRQLMGCLRRKSREDLL--RAYESVYNHGNGSSQLGV 320
            ..|.|     :..::|..|:||...:..  :|:.||::|..::|:  ....:.|:...|....|.
Human   321 SSWAVSFQPAKYARMLATKVGCNVSDTV--ELVECLQKKPYKELVDQDIQPARYHIAFGPVIDGD 383

  Fly   321 ILPEG--LPLEQ-RLRNKTLPPVLLGITSNEGAFLQDYWLD-----VAREGQVALHKYINHTLLP 377
            ::|:.  :.:|| ...|.   .::||:...||....:..:|     .|.:...|:..::::
Human   384 VIPDDPQILMEQGEFLNY---DIMLGVNQGEGLKFVENIVDSDDGISASDFDFAVSNFVDN---- 441

  Fly   378 NVMRALESVGEESSTQLAAIRWRYFNGKGEGVSH--------LLAGMQRLLSESLYELPYSRILE 434
                 |....|........|::.|.:....   |        |||    |.::..:..|.....:
Human   442 -----LYGYPEGKDVLRETIKFMYTDWADR---HNPETRRKTLLA----LFTDHQWVAPAVATAD 494

  Fly   435 LLN--GTTSYAYVFDHSHSMDMRGRRNLFGGASHSSDLPLLLGPSLF--QQIARRRFSGEEEQLC 495
            |.:  |:.:|.|.|.|....|   :...:..|:|..::|.:||..:.  .::....||..:..|.
Human   495 LHSNFGSPTYFYAFYHHCQTD---QVPAWADAAHGDEVPYVLGIPMIGPTELFPCNFSKNDVMLS 556

  Fly   496 RKIRGAFANFIKNGNPT-------------PGRIYD-GWLPYNKENPFVYSLGEQAKTPQTGSVD 546
            ..:...:.||.|.|:|.             |.|..: .|..|::::.....:|.:.:..:....:
Human   557 AVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWTRYSQKDQLYLHIGLKPRVKEHYRAN 621

  Fly   547 EA--------------EVDKLLRGETGAPGLDRSLSRSNRHDTYRAAPSNSYTASNQLDSGYSNH 597
            :.              ::.:.....|..|..|         .|:|....||...::
Human   622 KVNLWLELVPHLHNLNDISQYTSTTTKVPSTD---------ITFRPTRKNSVPVTS--------- 668

  Fly   598 LQMVYGFWQVLMPLEREEDLR---GGGALGQRVRLLEASADAARYRQGFYAMLGLVCLLLACLCL 659
                      ..|..:::|.:   ...::.||....|.|...|         :|...|.|..|..
Human   669 ----------AFPTAKQDDPKQQPSPFSVDQRDYSTELSVTIA---------VGASLLFLNILAF 714

  Fly   660 CVYLLKRDP--NAMRRRSASSASDCYSLXH 687
            .....|:|.  :.:.||.:...:....| |
Human   715 AALYYKKDKRRHDVHRRCSPQRTTTNDLTH 744

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12869	NP_001369085.1	COesterase	27..541	CDD:395084	144/578 (25%)
NLGN1	NP_001352852.1	COesterase	52..626	CDD:395084	144/588 (24%)