Protein Alignment CG12869 and NLGN4Y

DIOPT Version :10

• Sequence 1: NP_001369085.1
• Gene: CG12869 / 36616
• FlyBaseID: FBgn0033943
• Length: 839
• Species: Drosophila melanogaster
• Sequence 2: NP_001352513.1
• Gene: NLGN4Y / 22829
• HGNCID: 15529
• Length: 836
• Species: Homo sapiens
• Alignment Length: 571
• Identity: 142/571 - (24%)
• Similarity: 240/571 - (42%)
• Gaps: 82/571 - (14%)

  Fly    26 AQQTHIKLEQGDLIGLKV-FPDGTRGAVYAFLGIPYAQAPINELRFAPAKPSSSFNRTLQATTMQ 89
            ||...:....|.:.||:. .|....|.|..:||:|||..|..|.||.|.:..||:.....||...
Human    43 AQYPVVNTNYGKIQGLRTPLPSEILGPVEQYLGVPYASPPTGERRFQPPESPSSWTGIRNATQFS 107

  Fly    90 PLCPQ----------LANTIYDESSDGSMPRSVSTDEDCLYLNIWTP-ESGM------------- 130
            .:|||          :....:..|.|..|......:||||||||:.| |.|.
Human   108 AVCPQHLDERFLLHDMLPIWFTTSLDTLMTYVQDQNEDCLYLNIYVPMEDGTNIKRNADDITSND 172

  Fly   131 ---------RYGKLPIVVIVTGEEFAYDWPRNRINGLDLAGEG-IVVVSVQYRNNIYGWLSLGEQ 185
                     :..|.|::|.:.|..: .:...|.|:|..||..| ::|:::.||..|.|:||.|:|
Human   173 HGEDKDIHEQNSKKPVMVYIHGGSY-MEGTGNMIDGSILASYGNVIVITINYRLGILGFLSTGDQ 236

  Fly   186 HRNVPGNYGLSDVQMALRWIRRNADAFGGNPDHITLLGHGSGGAPLALVATLEDSSQVKQLVLMS 250
              ...|||||.|...|||||..|..||||:|..:|:.|.|:|.:.::|:.....|..:.|..::.
Human   237 --AAKGNYGLLDQIQALRWIEENVGAFGGDPKRVTIFGSGAGASCVSLLTLSHYSEGLFQKAIIQ 299

  Fly   251 PGPIMRALGQNHQKWIVETGQVLVQKLGCQFEEAQRRQLMGCLRRKSREDLLR--AYESVYNHGN 313
            .|..:.:...|:|.  .:..::|..|:||...:.  ..::.||:.|:.::|::  ...:.|:...
Human   300 SGTALSSWAVNYQP--AKYTRILADKVGCNMLDT--TDMVECLKNKNYKELIQQTITPATYHIAF 360

  Fly   314 GSSQLGVILPEG--LPLEQ-RLRNKTLPPVLLGITSNEGAFLQDYWLDVAREGQVALHKYINHTL 375
            |....|.::|:.  :.:|| ...|.   .::||:...||....|..:|  .|..|..:.:  ...
Human   361 GPVIDGDVIPDDPQILMEQGEFLNY---DIMLGVNQGEGLKFVDGIVD--NEDGVTPNDF--DFS 418

  Fly   376 LPNVMRALESVGEESSTQLAAIRWRYFN-GKGEGVSHLLAGMQRLLSESLYELPYSRILEL--LN 437
            :.|.:..|....|...|....|::.|.: ...|........:..|.::..:..|.....:|  ..
Human   419 VSNFVDNLYGYPEGKDTLRETIKFMYTDWADKENPETRRKTLVALFTDHQWVAPAVATADLHAQY 483

  Fly   438 GTTSYAYVFDHSHSMDMRGRRNLFGGASHSSDLPL-----LLGPSLFQQIARRRFSGEEEQLCRK 497
            |:.:|.|.|.|....:|:..   :..::|..::|.     ::||:   ::....||..:..|...
Human   484 GSPTYFYAFYHHCQSEMKPS---WADSAHGDEVPYVFGIPMIGPT---ELFSCNFSKNDVMLSAV 542

  Fly   498 IRGAFANFIKNGNPT-------------PGRIYD-GWLPYNKENPFVYSLG 534
            :...:.||.|.|:|.             |.|..: .|..||.::.....:|
Human   543 VMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWSKYNPKDQLYLHIG 593

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12869	NP_001369085.1	COesterase	27..541	CDD:395084	141/570 (25%)
NLGN4Y	NP_001352513.1	COesterase	44..610	CDD:395084	141/570 (25%)