Protein Alignment CG12869 and Nlgn1

DIOPT Version :10

• Sequence 1: NP_001369085.1
• Gene: CG12869 / 36616
• FlyBaseID: FBgn0033943
• Length: 839
• Species: Drosophila melanogaster
• Sequence 2: XP_006535478.1
• Gene: Nlgn1 / 192167
• MGIID: 2179435
• Length: 863
• Species: Mus musculus
• Alignment Length: 764
• Identity: 170/764 - (22%)
• Similarity: 282/764 - (36%)
• Gaps: 200/764 - (26%)

  Fly    50 GAVYAFLGIPYAQAPINELRFAPAKPSSSFNRTLQATTMQPLCPQLANTIYDESSDGSMPRSV-- 112
            |.|..|||:|||..|..|.||.|.:|.|.::....||...|:|||  |.|     ||.:|..:
Mouse    75 GPVIQFLGVPYAAPPTGEHRFQPPEPPSPWSDIRNATQFAPVCPQ--NII-----DGRLPEVMLP 132

  Fly   113 ---------------STDEDCLYLNIWTP------------------------------------ 126
                           ...||||||||:.|
Mouse   133 VWFTNNLDVVSSYVQDQSEDCLYLNIYVPTEDVKRISKECARKPGKKICRKGGPLTKKHTDDLGD 197

  Fly   127 ----------ESGMRYGKLPIVVIVTGEEFAYDWPRNRINGLDLAGEG-IVVVSVQYRNNIYGWL 180
                      :||   |..|::|.:.|..: .:...|..:|..||..| ::|::|.||..:.|:|
Mouse   198 NDGAEDEDIRDSG---GPKPVMVYIHGGSY-MEGTGNLYDGSVLASYGNVIVITVNYRLGVLGFL 258

  Fly   181 SLGEQHRNVPGNYGLSDVQMALRWIRRNADAFGGNPDHITLLGHGSGGAPLALVATLEDSSQVKQ 245
            |.|:|  ...|||||.|:..||||...|...|||:|..||:.|.|:||:.:.|: ||...|:..:
Mouse   259 STGDQ--AAKGNYGLLDLIQALRWTSENIGFFGGDPLRITVFGSGAGGSCVNLL-TLSHYSEGNR 320

  Fly   246 LVLMSPGPIMRALGQNH---QKWIV-----ETGQVLVQKLGCQFEEAQRRQLMGCLRRKSREDLL 302
            ....:.|...||:.|:.   ..|.|     :..::|..|:||...:..  :|:.||::|..::|:
Mouse   321 WSNSTKGLFQRAIAQSGTALSSWAVSFQPAKYARILATKVGCNVSDTV--ELVECLQKKPYKELV 383

  Fly   303 --RAYESVYNHGNGSSQLGVILPEG--LPLEQ-RLRNKTLPPVLLGITSNEGAFLQDYWLD---- 358
              ....:.|:...|....|.::|:.  :.:|| ...|.   .::||:...||....:..:|
Mouse   384 DQDVQPARYHIAFGPVIDGDVIPDDPQILMEQGEFLNY---DIMLGVNQGEGLKFVENIVDSDDG 445

  Fly   359 -VAREGQVALHKYINHTLLPNVMRALESVGEESSTQLAAIRWRYFNGKGEGVSH--------LLA 414
             .|.:...|:..::::         |....|........|::.|.:....   |        |||
Mouse   446 VSASDFDFAVSNFVDN---------LYGYPEGKDVLRETIKFMYTDWADR---HNPETRRKTLLA 498

  Fly   415 GMQRLLSESLYELPYSRILELLN--GTTSYAYVFDHSHSMDMRGRRNLFGGASHSSDLPLLLGPS 477
                |.::..:..|.....:|.:  |:.:|.|.|.|....|   :...:..|:|..::|.:||..
Mouse   499 ----LFTDHQWVAPAVATADLHSNFGSPTYFYAFYHHCQTD---QVPAWADAAHGDEVPYVLGIP 556

  Fly   478 LF--QQIARRRFSGEEEQLCRKIRGAFANFIKNGNPT-------------PGRIYD-GWLPYNKE 526
            :.  .::....||..:..|...:...:.||.|.|:|.             |.|..: .|..|:::
Mouse   557 MIGPTELFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWTRYSQK 621

  Fly   527 NPFVYSLGEQAKTPQTGSVDEA--------------EVDKLLRGETGAPGLDRSL--SRSNRHDT 575
            :.....:|.:.:..:....::.              ::.:.....|..|..|.:|  :|.|....
Mouse   622 DQLYLHIGLKPRVKEHYRANKVNLWLELVPHLHNLNDISQYTSTTTKVPSTDITLRPTRKNSTPV 686

  Fly   576 YRAAPSNSYTASNQLDSGYSNHLQMVYGFWQVLMPLEREEDLRGGGALGQRVRLLEASADAARYR 640
            ..|.|:.......|..|.:|                           :.||....|.|...|
Mouse   687 TSAFPTAKQDDPKQQPSPFS---------------------------VDQRDYSTELSVTIA--- 721

  Fly   641 QGFYAMLGLVCLLLACLCLCVYLLKRDP--NAMRRRSASSASDCYSLXH 687
                  :|...|.|..|.......|:|.  :.:.||.:...:....| |
Mouse   722 ------VGASLLFLNILAFAALYYKKDKRRHDVHRRCSPQRTTTNDLTH 764

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12869	NP_001369085.1	COesterase	27..541	CDD:395084	144/598 (24%)
Nlgn1	XP_006535478.1	COesterase	52..646	CDD:395084	144/608 (24%)