DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12869 and cest-28

DIOPT Version :9

Sequence 1:	NP_001369085.1	Gene:	CG12869 / 36616	FlyBaseID:	FBgn0033943	Length:	839	Species:	Drosophila melanogaster
Sequence 2:	NP_504691.2	Gene:	cest-28 / 187305	WormBaseID:	WBGene00019654	Length:	548	Species:	Caenorhabditis elegans

Alignment Length:	562	Identity:	124/562 - (22%)
Similarity:	240/562 - (42%)	Gaps:	115/562 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 HLSPYISAQQTHIKLE------QGDL--IGLKVFPDGTRGAVYAFLGIPYAQAPINELRFAPAKP 75
            ||| ::..::...||.      ||::  ||.|.. ||       :||||:|: |:  :||...:|
Worm     4 HLS-HLEREKHSEKLNATCGPIQGNVYRIGDKTV-DG-------YLGIPFAK-PL--VRFKKPEP 56

  Fly    76 SSSFNRTLQATTMQPLCPQ---LANTIYDESSDGSMPRSVSTDEDCLYLNIWTPESGMR-YGKL- 135
            :.::......|...|.|||   .|..|..:..|      :..:.:||.||:::..|..: :.|.
Worm    57 AGTWEEVRDCTKYGPRCPQSGPFAEAINFQKDD------IPDEANCLTLNVFSKISDSKNFNKTR 115

  Fly   136 PIVVIVTGEEFAYDWPRNRINGLDLAG----EGIVVVSVQYRNNIYGWLSLGEQHRNVPGNYGLS 196
            |::|.:.|..:.....|:..: ..:||    :.:|||::.||..|.|:.:.|:  ...|||:.|.
Worm   116 PVMVYIHGGGYECSASRDYCD-YSVAGTLPLKDVVVVTLNYRVGILGFFTTGD--TVCPGNFALW 177

  Fly   197 DVQMALRWIRRNADAFGGNPDHITLLGHGSGGAPLALVATLEDSSQV-KQLVLMSPGPIMRALGQ 260
            |:.:.|.||:::.::|||:|.:||:.|..:|.|.:.|:|....|..: .::::||.|.:.
Worm   178 DLTLGLNWIQKHIESFGGDPGNITIFGQSAGAACVDLLALSPHSRDLFNRVIVMSGGALC----- 237

  Fly   261 NHQKWIVETGQ-------VLVQKLGCQFEEAQRRQLMGCLRRKSREDLLRAYESVYNHGNGSSQL 318
               ::.|.|..       ...:.||  ::....:.|...::.|..|::.:.      :|......
Worm   238 ---EYAVRTANSQAKVCYEFARHLG--YDGTNSQTLFNWMKSKPLEEIEKM------NGFQVPAS 291

  Fly   319 GVI----------LPEGLPLEQRLRNKTLPPVLLGITSNEGAFLQDYWLDVAREGQVALHKYIN- 372
            |::          .|:.|. |.|: ......:::|...:||.|. ::.:........||..|:|
Worm   292 GILAWTPNLDDDFFPKSLD-ELRI-GAPKKDIMMGFAEHEGLFF-EFLIKDPTPPLEALKLYVNE 353

  Fly   373 --------------HTLLPNVMRALESVGEESSTQLAAIRWRYFNGKGEGVSHLLAGMQRLLSES 423
                          :.::....|.:|...|:|:.:      |..:..|:.          |.:..
Worm   354 YYKKDTGDHFEATRNKIIEFYSRNVEDTDEKSTKE------RLIDFVGDA----------LFTAG 402

  Fly   424 LYELPYSRILELLNGTTSYAYVFDHSHSMDMRGRRNL--FGGASHSSDLPLLLGPSLFQQIARRR 486
            :::...:.   |.:|...:.|:||:.:......:...  |...:|.:||..:||..|:...   :
Worm   403 VFDNAKNC---LKHGNNVWLYIFDYCNPSGFGNQEEFMTFVAPTHCTDLRYVLGEGLYSDF---Q 461

  Fly   487 FSGEEEQLCRKIRGAFANFIKNGNPTPGRIYDGWLPYNKENP 528
            .:.||.::..|:...::||.|.|||......: |..:..:||
Worm   462 PTEEEHKMIEKMTTIYSNFAKYGNPNEHGSSE-WEKFTLDNP 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12869	NP_001369085.1	COesterase	27..541	CDD:395084	121/554 (22%)
cest-28	NP_504691.2	COesterase	17..516	CDD:278561	120/548 (22%)
cest-28	NP_504691.2	Aes	<112..>222	CDD:223730	34/112 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900