Protein Alignment CG12869 and cest-3

DIOPT Version :9

• Sequence 1: NP_001369085.1
• Gene: CG12869 / 36616
• FlyBaseID: FBgn0033943
• Length: 839
• Species: Drosophila melanogaster
• Sequence 2: NP_510042.2
• Gene: cest-3 / 181385
• WormBaseID: WBGene00008451
• Length: 588
• Species: Caenorhabditis elegans
• Alignment Length: 717
• Identity: 140/717 - (19%)
• Similarity: 254/717 - (35%)
• Gaps: 219/717 - (30%)

  Fly    18 IHLSPYI-------SAQQTHIKLEQGDLIGLKVFPDGTRGAVYAFLGIPYAQAPINELRFAPAKP 75
            :|:..||       .:.|..|....|.|.|..|..|     .:.|..:|:|:.|:.:|||:..:.
 Worm     4 LHVLYYILFVFTLNGSGQRIISTTYGKLEGKTVNVD-----QHMFKNVPFAKPPLGKLRFSLPEW 63

  Fly    76 SSSFNRTLQATTMQPLCPQLANTIYDESSDGSMPRSVSTDEDCLYLNIWTPESGMRYGKLPIVVI 140
            ::.:.....||...|.|       :..||..:........|||||||::|.|..::......||.
 Worm    64 TNPWKNIRNATEYSPSC-------FSNSSMRTDSNFFPMSEDCLYLNVFTNEYCLKSKNCSTVVY 121

  Fly   141 VTGEEFAYDWPRNRINGLDL---------------AGEGIVVVSVQYRNNIYGWLSLGEQHRNVP 190
            ..|            .|:::               ..|.:|.:...||..|:|.|..|..:. ||
 Worm   122 YHG------------GGINMDSAVQFNDTFILERYVKENVVFIIPAYRLGIFGLLYFGSNNL-VP 173

  Fly   191 GNYGLSDVQMALRWIRRNADAFGGNPDHITLLGHGSGGAPLALVATLE-----DSSQVKQLVLMS 250
            .|..:.|.::|||:|.:....|||:.|.|.|:|| |.||.::|:....     |...:.:::::|
 Worm   174 QNLAIHDCELALRFIHQEISNFGGHKDDINLMGH-SAGAHISLIFGFSRHIDPDHKLINRIIVLS 237

  Fly   251 PGPIMRALGQNHQKWIVETGQVLVQKLGCQFEEAQRR--QLMGCLRRKSREDLLRAYESVYNHGN 313
            |.|     ..:..:.:::......:::||.......|  :::.|||:|....|
 Worm   238 PVP-----SYDMPELLIKNCYDFAERVGCYKRNVTARDTEIVKCLRKKDARGL------------ 285

  Fly   314 GSSQLGVILPEGLPLEQRLRNKTLPPVLLGITSNEGAFLQDYWLDVAREGQVALHKYINHTLLPN 378
                        :.:::.:.|..|  ......:.|....:|..:...:|..|.....|.:|:
 Worm   286 ------------MSMQRLMENDRL--YFWNFLAGEPFMYRDESIADFKEYAVKRDMLIGNTV--- 333

  Fly   379 VMRALESVGEESSTQLAAIRWRYFNGKGEGVSHLLAGMQRLLSESLYEL-----------PYSRI 432
                     :|       ::|:....:...::......     |:.||:           |.:..
 Worm   334 ---------DE-------VKWKRLKKENPAIAGSFMDW-----ENPYEVAHKFNFYHDSAPVNST 377

  Fly   433 LE-----LLNGTTSYA----------YVFD-----HSHSMDMRGRRNLFGGAS----HSSDLPLL 473
            .|     :...|.:||          |:|.     .||..||:    .|.|..    |:||:.::
 Worm   378 YESFTQGIFVSTATYAEAQANAGGTVYLFQSNQQPSSHVSDMQ----YFVGTHREDYHTSDMDIM 438

  Fly   474 LGPSLFQQIARRRFSGEEEQLCRKIRGAFANFIKNGNPTPGRIYDGWLPYNKENPFVYSL---GE 535
              .:.:.::                   ..||.|.|:|:|     .|.|........|:|   .|
 Worm   439 --DTFYSKM-------------------IVNFTKFGSPSP-----VWEPLVPSRMNYYALEVNTE 477

  Fly   536 QAKTPQ-TGSVDEAEVDKLLRGETGAPGLDRSLSRSNRHDTYRAAPSNSYTASNQLDSGYSNHLQ 599
            :...|: .....|::|:......|   ..||.::|..:       .||..:.:
 Worm   478 KGIWPRMEEDFHESDVNFWFINMT---AFDREVTRQKK-------TSNGTSLT------------ 520

  Fly   600 MVYGFWQVLMPLEREEDLRGGGALGQRVRLLEASADAARYRQGFYAMLGLVCLLLACLCLCVYLL 664
                 |..:.|          |.:....:..|:|:.....:..|:|::.:|.|:|..|   :|:|
 Worm   521 -----WSPMHP----------GPVILPTKTNESSSFDISSQWWFFAIIVVVALILFYL---IYVL 567

  Fly   665 KR 666
            ||
 Worm   568 KR 569

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12869	NP_001369085.1	COesterase	27..541	CDD:395084	113/573 (20%)
cest-3	NP_510042.2	Abhydrolase	23..496	CDD:304388	115/583 (20%)
		Aes	<118..>254	CDD:223730	36/154 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900