Protein Alignment CG12869 and cest-9.1

DIOPT Version :10

• Sequence 1: NP_001369085.1
• Gene: CG12869 / 36616
• FlyBaseID: FBgn0033943
• Length: 839
• Species: Drosophila melanogaster
• Sequence 2: NP_001359584.1
• Gene: cest-9.1 / 181383
• WormBaseID: WBGene00007692
• Length: 614
• Species: Caenorhabditis elegans
• Alignment Length: 706
• Identity: 162/706 - (22%)
• Similarity: 271/706 - (38%)
• Gaps: 159/706 - (22%)

  Fly    16 ILIHLSPYISAQQTHIKLEQGDLIGLKVFPDGTRGAVYAFLGIPYAQAPINELRFAPAKPSSSFN 80
            :||...|...:.:. |:...|.|.|:.|: ...:...|.|..:|:|:.|:..||||..:...|::
 Worm     7 LLILFIPQFQSLKV-IQTSYGKLRGITVW-SNDKNHRYMFKSVPFAKPPVGNLRFAKPQNPESWS 69

  Fly    81 RTLQATTMQPLCPQLANTIYDESSDGSMPRSVSTDEDCLYLNIWTPESGMRYGKLPIVVIVTGEE 145
            ..|.|:...|.|  ::|     ||..|.|:. ...|||||:||:|.|..:. .|.|::|...|..
 Worm    70 GILDASKYSPAC--MSN-----SSSTSTPQK-HYSEDCLYINIFTSEKCLN-SKCPVIVYFHGGA 125

  Fly   146 FAYDWP--RNRINGLD-LAGEGIVVVSVQYRNNIYGWLSLGEQHRNVPGNYGLSDVQMALRWIRR 207
            :..|..  .|....|| .|.|.:|.|....|..::|.|..|.... :..|..|.|...||.::..
 Worm   126 YNLDSAIMFNDTFILDRYAAEDVVFVIPAVRLGVFGQLYFGPSDL-LSENLFLYDAVQALSFVHS 189

  Fly   208 NADAFGGNPDHITLLGHGSGGAPLALVATLEDSSQVKQLVLMSPGP-------IMRALGQ-NHQK 264
            ..:.|||:...:|.:||.|||       |:.|:....:|:  .||.       ::.|.|. ....
 Worm   190 EINYFGGDSKRVTAMGHSSGG-------TIVDALGFSKLI--DPGVKLFQQMIVLSATGMFGFYD 245

  Fly   265 WIVETGQVLVQKLGC------QFEEAQRRQLMGCLRR-KSREDLL--RAYESVYNHGNGSSQLGV 320
            .:|:....:|:|.||      ....|...:::.|:|: ..||.||  |..|.|.:....|
 Worm   246 MVVDNSFAIVEKFGCYNGTKDDRPNANIAEMLDCMRQIDGREMLLMQRHMEEVDDRDFRS----- 305

  Fly   321 ILPEGLP-LEQRLR---NKTLPP---VLLGITSNE-------GAFLQDYWLDVAREGQVALHKYI 371
             :..|.| ||...:   .|..||   :|.|.|.:|       ..::...:||.  :..||:.:|.
 Worm   306 -VLRGAPFLESNGKIADLKKSPPSRNLLYGTTEHEFRNVDHMNPYISGIFLDF--DNPVAVARYY 367

  Fly   372 NHTLLPNVMRALESV--GEESSTQLAAIRWRYFNGKGEGVSHLLAGMQRLLSESLYELPYSRILE 434
            :..|:.|    ||::  |:.::..:.|                                 |....
 Worm   368 DEQLMAN----LETMINGDAAAIFICA---------------------------------STFST 395

  Fly   435 LLNGTTSYAYVFDHSHSMDMRGRRNLFGGASHSSDLPLLLGPSLFQQIARRRFSGEEEQLCRKIR 499
            .:..|.:..|:|      :.|.:...|    |.||:...:|  :.::|..|......:....|:
 Worm   396 AMANTGADVYLF------ETRQKPYSF----HVSDMQYFVG--IHREIYHRPDMDILDTFYSKL- 447

  Fly   500 GAFANFIKNGNPTPGRIYDGWLPYNKENPFVYSLGEQAKTPQTGSV-----DEAEVDKLLRGETG 559
              ..||.|.|.|:|     .|.|.:.|......|...:...: |.|     .|.|:: |..||
 Worm   448 --LVNFTKMGVPSP-----EWAPLDPERMNYLELKVDSDMKE-GPVMLEGFHEKEME-LWFGE-- 501

  Fly   560 APGLDRSLSRSNRHDTYRAAPSNSYTASNQLDSGYSNHLQMVYGFWQVL-MPLEREEDLRGGGAL 623
            ....||::::..:.   :..|........||.            :|:.. .|....:..:|..::
 Worm   502 MMEFDRNVTKIRQS---QGLPPEHLDIETQLK------------YWETTNKPEILTKTTKGFTSI 551

  Fly   624 GQ----RVRLLEASADAARYRQG--------FYAMLGLVCLLLACLCLCVYLLKRD 667
            .|    ......|||.::..:.|        ||.::.|:.||:..:.:|:...||:
 Worm   552 HQDNNSNTVTTTASAQSSLLKNGSSILKQWWFYLIIFLMILLVVLIVICLRKPKRE 607

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12869	NP_001369085.1	COesterase	27..541	CDD:395084	131/549 (24%)
cest-9.1	NP_001359584.1	alpha/beta hydrolases	19..484	CDD:473884	131/551 (24%)