Protein Alignment CG12869 and cest-2.3

DIOPT Version :10

• Sequence 1: NP_001369085.1
• Gene: CG12869 / 36616
• FlyBaseID: FBgn0033943
• Length: 839
• Species: Drosophila melanogaster
• Sequence 2: NP_506510.2
• Gene: cest-2.3 / 179918
• WormBaseID: WBGene00013873
• Length: 665
• Species: Caenorhabditis elegans
• Alignment Length: 567
• Identity: 156/567 - (27%)
• Similarity: 238/567 - (41%)
• Gaps: 116/567 - (20%)

  Fly    10 ILRLL--PILIHLSPYISAQQTHIKLEQGDLIGLKVF-----PDGTRGAVYAFLGIPYAQAPINE 67
            ||:.|  .:|||||  ||   |.|:|..|.:.| |:.     |.|.:.|. .||||||.:.||.|
 Worm     2 ILQYLYFAVLIHLS--IS---TRIQLSTGTIEG-KILNATYSPFGNQTAT-VFLGIPYVEPPIGE 59

  Fly    68 LRFAPAKPSSSFNRTLQATTMQPLCPQLANTIYDESSDGSMPRSVSTDEDCLYLNIWTPESGMRY 132
            |||...:...|:...|:....:|.|.......:.....|.:      .|||||.|::|.:..::.
 Worm    60 LRFRKPRLLKSWEGVLETKDYKPACMSYWRKTFKNGFVGEI------SEDCLYANVFTNQYCLQN 118

  Fly   133 GKLPIVVIVTG-----EEFAYDWPRNRINGLDLAGEGIVVVSVQYRNNIYGW-LSLGEQHRNVPG 191
            ....::::|.|     |..:...|...||........||||:..||..::|: :..||....
 Worm   119 KNCSVMIVVHGGRLVCESGSAFKPEIFINNFVGQDRNIVVVTFNYRLGVFGFGVFNGETGDT--- 180

  Fly   192 NYGLSDVQMALRWIRRNADAFGGNPDHITLLGHGSGGAPLAL---VATLEDSSQVKQLVLMSPGP 253
            |..:.|:..|::|:|:..|.||||.|.||:.|| |.||.|.:   .:||......:|:|:.:|
 Worm   181 NVAMYDMLEAVKWVRKEIDQFGGNKDRITMAGH-SAGAGLIVDFTSSTLSKGLLHQQIVMSAP-- 242

  Fly   254 IMRALGQNHQKWIVETGQVLV-QKLGC--------QFEEAQRRQLMGCLRRKSREDLLRAYESVY 309
                 .|:..|.....|..:| |.:||        :..:.|..:...||:.||.:|||.|..|:.
 Worm   243 -----LQDISKSANFKGMTIVAQNVGCIPKEYGFRKLSKTQINKTYLCLQNKSAQDLLHAQLSMQ 302

  Fly   310 NHGN---GSSQL-GVIL---PEGLPLEQRLRNKTLPPV--LLGITSNEGAFLQD--YWLDVAREG 363
            .:..   ||.:: |..:   |:.|     ....|:.|:  .:|.|:.|   |:|  |..|...:
 Worm   303 QNSTFYFGSPRVDGDFITDYPDNL-----FNFNTIYPINTFIGTTTGE---LRDSLYITDPKND- 358

  Fly   364 QVALHKYINHTLLPNVMRALESVG-------EESSTQLAAIRWRYFNGKGEGVSHLLAGMQRLLS 421
                  .|...||.|:   .|.||       ||.:.:....   |.||..          .:.||
 Worm   359 ------RIKEQLLKNM---CEHVGYELFEKPEEFTKKCGNY---YKNGTD----------AQFLS 401

  Fly   422 ESLYELPYSRILELLNG-TTSYAYVFDHSHSMDMRGRRNLF------GGASHSSDLPLLLGPSLF 479
            :.: |. ||..:::.|. ..:.:.||.:|:  |.:|....|      ....||.||....|.|
 Worm   402 DDM-EF-YSGAIKVANAHKRANSKVFMYSY--DYKGAGTAFHKYLEAPSPHHSEDLIYTFGTS-- 460

  Fly   480 QQIARRRFSGEEEQLCRKIRGAFANFIKNGNPTPGRIYDGWLPYNKE 526
                |..|..::..:.|...|..||||...:|:|.:... |..|.:|
 Worm   461 ----RGPFVAKDYVIERIYSGMLANFINFEDPSPSKTQQ-WRQYTQE 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12869	NP_001369085.1	COesterase	27..541	CDD:395084	146/548 (27%)
cest-2.3	NP_506510.2	alpha/beta hydrolases	17..532	CDD:473884	147/550 (27%)