Protein Alignment CG12869 and cest-2.2

DIOPT Version :9

• Sequence 1: NP_001369085.1
• Gene: CG12869 / 36616
• FlyBaseID: FBgn0033943
• Length: 839
• Species: Drosophila melanogaster
• Sequence 2: NP_001256567.1
• Gene: cest-2.2 / 179917
• WormBaseID: WBGene00013874
• Length: 672
• Species: Caenorhabditis elegans
• Alignment Length: 686
• Identity: 154/686 - (22%)
• Similarity: 255/686 - (37%)
• Gaps: 145/686 - (21%)

  Fly    25 SAQQTHIKLE------QGDLIGLKVFPDGTRGAVYAFLGIPYAQAPINELRFAPAKPSSSFNRTL 83
            :.:.|.:||.      :|..:.....|.|.:..: .|.|:||.:.|:..|||...:|...::..|
 Worm    14 NVRSTKVKLSSRTGTIEGRTLTASYSPLGNQTGI-VFFGVPYVEPPVGNLRFRKPRPPKPWDGVL 77

  Fly    84 QATTMQPLCPQLANTIYDESSDGSMPRSVSTDEDCLYLNIWTPESGMRYGKLPIVVIVTGEEF-- 146
            :|...:..|.......|.....|.:      .|||||.|::|.:..:.:....:::.:.|..|
 Worm    78 EAKEYKAACMSDQKKTYKNGVGGPV------SEDCLYANVFTNQYCLEHKNCSVMLTIHGGRFVI 136

  Fly   147 ----AYDWPRNRINGLDLAGEGIVVVSVQYRNNIYGWLSLGEQHRNVPGNYGLSDVQMALRWIRR 207
                ||| |...||.....|..||||:..||..::|...|...:::.  |:||.|:...:||.|:
 Worm   137 ESASAYD-PEIIINNFVGQGRNIVVVTFNYRLGLFGLGMLNGDNQDT--NFGLYDILEVVRWTRK 198

  Fly   208 NADAFGGNPDHITLLGHGSGGAPLALVATLE-DSSQVKQLVLMSPGPIMRALGQNHQKWIVETGQ 271
            ....|||:.|.||:.||.:|....|..:|.. ....:.|.::||     .::....:|..|:...
 Worm   199 EIKNFGGDKDRITMQGHSAGAVFTAAFSTSPLSKGLIHQQIIMS-----ASMSNLSKKSNVKELT 258

  Fly   272 VLVQKLGC--------QFEEAQRRQLMGCLRRKSREDLLRAYESVYNHGNGSSQLG--------- 319
            |:.:.:||        :....:..:...|||.||.:.:|.|  .:|...|.:..:|
 Worm   259 VVARIVGCLPDEHGFPKLSNVEVEKAYTCLRSKSAQQILDA--QLYMLRNTTYYIGQGHIDGIYQ 321

  Fly   320 VILPEGLPLEQRLRNKTLPPV--LLGITSNEGAFLQD--YWLDVAREGQVALHKYINHTLLPNVM 380
            |..|:.|     ....::.|:  ::|.|:.|   |.|  |.:|....|:       ...||.|:
 Worm   322 VDYPDNL-----YATNSIYPINTMIGTTTAE---LMDSRYIVDPKNTGK-------KEILLQNL- 370

  Fly   381 RALESVGEE--SSTQLAAIRWRYFNGKGEGVSHLLAGMQRLLSESLYELPYSRILELLN-----G 438
              .|.:|.|  ...:..:.:.|.|...||....|...|:.          |...::|.|     .
 Worm   371 --CEHIGYELYKEPEEFSQKCRNFYKNGEDAKSLGDDMEF----------YYGAIQLANVHSSKD 423

  Fly   439 TTSYAYVFDHSHSMDMRGRRNLFGGASHSSDLPLLLGPSLFQQIARRRFSGEEEQLCRKIRGAFA 503
            |..:.|.||:..:.:...:.:......|..|.....|.:      |..||.::..:.....|.||
 Worm   424 TNVFVYSFDYKEAGNAYKKYDKSLSPKHGEDFAYAFGTN------RGNFSTKDYVIEYIYSGMFA 482

  Fly   504 NFIKNGNPTPGRIYDGWLPYNKENPFVYSLGEQAKTPQTGSVD---------------------- 546
            :|:..|:|:|....: |..|..|....:.:.........|..|
 Worm   483 DFVNFGDPSPLEDQE-WAQYTPEKREYFLIDFDKNFTMPGMKDHYYPKALEFWSTCGSKSFKEHF 546

  Fly   547 EAEVDKLLRGETGAPGLDRSLSRSNRHDTYRAAPSNSYTASNQLDSGYSNHLQMVYGFWQVLMPL 611
            ...||..:.|..    |:..:|..|.::|   .|..::   .|.|..|:
 Worm   547 SPSVDIFIIGNL----LNPIMSHLNHNET---GPDKTF---EQFDKLYN---------------- 585

  Fly   612 EREEDLRGGGALGQRVRLLEASADAARYRQGFYAML 647
            ||||.|:    |.:.||.||......|.|.....||
 Worm   586 EREEFLK----LLKAVRKLEIQKKMWRGRSSKDLML 617

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12869	NP_001369085.1	COesterase	27..541	CDD:395084	127/554 (23%)
cest-2.2	NP_001256567.1	Abhydrolase	25..534	CDD:389770	126/560 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.100