Protein Alignment CG12869 and cest-5.1

DIOPT Version :10

• Sequence 1: NP_001369085.1
• Gene: CG12869 / 36616
• FlyBaseID: FBgn0033943
• Length: 839
• Species: Drosophila melanogaster
• Sequence 2: NP_501022.3
• Gene: cest-5.1 / 177429
• WormBaseID: WBGene00015279
• Length: 580
• Species: Caenorhabditis elegans
• Alignment Length: 575
• Identity: 147/575 - (25%)
• Similarity: 233/575 - (40%)
• Gaps: 122/575 - (21%)

  Fly    11 LRLLPILIHLSPYISAQQTHIKLEQGDLIGLKVFPDGTRGAVYAFLGIPYAQAPINELRFAPAKP 75
            ||||.::..::   :|....|....|.|.|.::      |..:.|..||:|:.|:..|||...:.
 Worm     4 LRLLLLIFIIN---AADSLIIHTSFGHLEGAEI------GDYHLFKKIPFAKPPVGNLRFQKPEA 59

  Fly    76 SSSFNRTLQATTMQPLCPQLANTIYDESSDGSMPRSVSTDEDCLYLNIWTPESGMRYGKLPIVVI 140
            :..::....|....|.|  ::|     ||....|:. ..|||||::||:|.:..::.....|.|.
 Worm    60 AGKWDGIRSAIEYGPAC--MSN-----SSKTKSPQK-WVDEDCLHVNIFTSKKCLKSRNCAIAVY 116

  Fly   141 VTGEEFAYDWP--RNRINGLD-LAGEGIVVVSVQYRNNIYGWLSLGEQHRNV-PGNYGLSDVQMA 201
            :.|....||..  .|....|| .....:::|...:|..|:...::..|  || |.|..|.|:.:|
 Worm   117 IHGGGLTYDSAVMFNDTVLLDTFVKRDVILVIPGFRLGIFSHFTVHNQ--NVAPNNLALYDITLA 179

  Fly   202 LRWIRRNADAFGGNPDHITLLGHGSGGAPLALVATL-----EDSSQVKQLVLMSPGPIMRALGQN 261
            |.:::....:||||...|||.||..||. ||.:.|.     .|.|..:|.::||.|.....| ::
 Worm   180 LEFVKSEIHSFGGNSQKITLFGHSYGGG-LASMMTFSSEINRDLSLFQQAIVMSGGFYFEEL-KD 242

  Fly   262 H---QKWIVETGQVLVQ-KLGCQFEEAQRRQ-LMGCLRRKSREDLLRAYESVYNHGNGSSQLGVI 321
            |   .|..||.....|. ||..:.|.:|:.. :|.||::.|..:|||....:.:.|..... |||
 Worm   243 HIEGTKRFVEYANCSVPLKLERKMERSQQEMYMMKCLQKLSGMELLRIQRLLEDKGYPDFG-GVI 306

  Fly   322 LPEGLPLE----QRLRNKTLPPVLLGITSNE----------GAFLQDYWLDVAREGQVALHKYIN 372
            |.|.|..:    :.|::....|:|.|.|:.|          |.:|:....|...|      ||.|
 Worm   307 LREPLFPDVKKFELLKSPKNIPMLTGCTNLEFDHESIKVPFGKYLEFENPDECDE------KYRN 365

  Fly   373 HTLLPNVMRALESVGEESSTQLAAIRWRYFNGKGEGVSHLLAGMQRLLSESLYELPYSRILELLN 437
                 :|...:|:.|..:.             |.:|:...|            :|..:.:||  |
 Worm   366 -----DVESGVENRGNHTD-------------KTQGIILPL------------KLQINNLLE--N 398

  Fly   438 GTTSYAYVFDHSHSMDMRGRRNLFGGASHSSDLPLLLGPSLFQQIARRRFSGEEEQLCRKIRGAF 502
            ..|:|.|    .::....||        |:.||..::|...|::      ...|..|.:..:...
 Worm   399 NVTAYLY----EYTYPKHGR--------HTDDLSYIMGVHAFEK------DENEVHLEQVYKDMV 445

  Fly   503 ANFIKNGNPTPGRIYDGWLPYNKENPFVY-------SLGEQAKTPQTGSVDEAEV 550
            .||||.|.|..|      ...:::|...|       :.||:   |:.....|.||
 Worm   446 INFIKLGEPGMG------FEKSEQNESTYFDIYWNETTGER---PRMRKYFEKEV 491

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12869	NP_001369085.1	COesterase	27..541	CDD:395084	138/548 (25%)
cest-5.1	NP_501022.3	alpha/beta hydrolases	17..495	CDD:473884	142/559 (25%)