Protein Alignment CG12869 and cest-5.2

DIOPT Version :10

• Sequence 1: NP_001369085.1
• Gene: CG12869 / 36616
• FlyBaseID: FBgn0033943
• Length: 839
• Species: Drosophila melanogaster
• Sequence 2: NP_501021.3
• Gene: cest-5.2 / 177428
• WormBaseID: WBGene00015284
• Length: 583
• Species: Caenorhabditis elegans
• Alignment Length: 510
• Identity: 121/510 - (23%)
• Similarity: 208/510 - (40%)
• Gaps: 99/510 - (19%)

  Fly    31 IKLEQGDLIGLKVFPDGTRGAVYAFLGIPYAQAPINELRFAPAKPSSSFNRTLQATTMQPLCPQL 95
            ||...|.|.|.:      .|....|..||:|:.||..|||...:.:..:|....||...|.|  :
 Worm    24 IKTSLGRLEGKQ------SGKYQLFRRIPFAKPPIGTLRFQKPESAEKWNGVWNATEYGPAC--M 80

  Fly    96 ANTIYDESSDGSMPRSVSTDEDCLYLNIWTPESGMRYGKLPIVVIVTGEEFAYDWPRNRINGLD- 159
            :|:.:.:|     |:. ..|||||::||:|.:..::.....:||.:.|.|..:|   :.:...|
 Worm    81 SNSTWTQS-----PQK-WVDEDCLHVNIFTSDKCLKSKDCAVVVYIHGGEIVFD---SAVMFNDT 136

  Fly   160 -----LAGEGIVVVSVQYRNNIYGWLSLGEQHRNV-PGNYGLSDVQMALRWIRRNADAFGGNPDH 218
                 ...:.:::|...:|..|:...::.:|  |: |.|..|.|:.:|..:::.....|||:...
 Worm   137 FLLESFVKQDVILVIPAFRLGIFSHFTVHDQ--NIAPNNLALYDIILAQEFVKSEIHNFGGDIQK 199

  Fly   219 ITLLGHGSGGAPLALVA----TLEDSSQVKQLVLMSPGPIMRALGQNHQKWIVETGQVLVQKLGC 279
            |||.||..||...:::|    ..:|.|..:::::||.......|.:.     :|....:|:..||
 Worm   200 ITLFGHSYGGTIASMMAFSSEINQDLSLFQRIIVMSANQYFDTLEEQ-----IERSDRVVKHAGC 259

  Fly   280 --------QFEEAQR-RQLMGCLRRKSREDLLRAYESVYNHGN---GSSQL-GVILPEGLPLEQR 331
                    :...:|: :.:|.||::.|..:||....|:...|.   |:..| |.:.|:...||.
 Worm   260 SVPTNLARKMNRSQKEKYMMKCLQKLSGMELLSVQRSLEEAGYPDIGNLVLRGPLFPDVTSLEM- 323

  Fly   332 LRNKTLPPVLLGITSNEGAFLQDYWLDVAREGQVALHKYINHTLLPNVMRALESVGEESSTQLAA 396
            |.:..:.|:|.|.|..|.            :.:...|....|..|.|.:...|...::..
 Worm   324 LESPKMIPMLAGCTKFES------------DDEDETHFIGKHFGLENPIECDEKYRKDLE----- 371

  Fly   397 IRWRYFNGKGEGVSHLLAGMQRLLSESLYELPYSRILEL-LNGTTSYAYVFDH-SHSMDMRGRRN 459
                  ||..:..:|.......::...|      |:.:| .:|..:|.|.|.: .|
 Worm   372 ------NGIFDRQNHSDKTQAIMVPTKL------RVDQLRKHGVPAYLYEFTYPKH--------- 415

  Fly   460 LFGGASHSSDLPLLLGPSLFQQIARRRFSGEEEQLCRKIRGAFANFIKNGNPTPG 514
                |.|:.||..::|...|::      ...||.|.:..|....||||.|.|..|
 Worm   416 ----AFHTDDLYYIMGIHPFEK------DENEEHLEKVYRNMLINFIKFGEPGMG 460

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12869	NP_001369085.1	COesterase	27..541	CDD:395084	121/510 (24%)
cest-5.2	NP_501021.3	alpha/beta hydrolases	21..498	CDD:473884	121/510 (24%)