DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12869 and cest-12

DIOPT Version :9

Sequence 1:	NP_001369085.1	Gene:	CG12869 / 36616	FlyBaseID:	FBgn0033943	Length:	839	Species:	Drosophila melanogaster
Sequence 2:	NP_499576.4	Gene:	cest-12 / 176642	WormBaseID:	WBGene00013540	Length:	850	Species:	Caenorhabditis elegans

Alignment Length:	687	Identity:	157/687 - (22%)
Similarity:	260/687 - (37%)	Gaps:	203/687 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 QQTH---IKLEQGDLIGLKVFPDGTRGAVY-----AFLGIPYAQAPINELRFAPAKPSSSFNRTL 83
            ||::   :...||.:.|.:|.....:..:|     ||.||||.|||:..||..|.:|.:.||.||
Worm    30 QQSNYVTVSCSQGSVQGRQVNLGNDQSQLYSGQANAFTGIPYCQAPVGNLRLQPPQPLNQFNTTL 94

  Fly    84 -QATTMQPLCPQLANTIYDESSDGSMPRSVSTDEDCLYLNIWTPESGMRYGKLPIVVIVTGEE-F 146
             .||..:|.||||       ::.|      .|:|||||||::||::|.....|.::|::.|.. |
Worm    95 HDATYFRPKCPQL-------NAGG------PTNEDCLYLNVYTPQAGNTNANLSVLVLIDGSNGF 146

  Fly   147 AY-DWPRNRINGL--DLAGEGIVVVSVQYRNNIYGWLSLGEQHRNVPGNYGLSDVQMALRWIRRN 208
            :. ...:|:..|:  :|....||||::|||....|:.:  ....:|..|.|:.|...|:|||:..
Worm   147 SNGGCDQNQEKGIISNLVQRQIVVVTMQYRIGALGFFT--TYTNSVQSNLGMLDQVQAMRWIKTE 209

  Fly   209 ADAFGGNPDHITLLGHGSGGAPLALVATLEDSSQ--VKQLVLMS--------PGPIMRALGQNHQ 263
            ...|||||:.||:.|...|...:: ...|...||  ..|.::.|        |.|   |:..|.|
Worm   210 IVNFGGNPNQITVAGQDDGACAVS-AHCLSPMSQNLFNQAIVQSGSVYSCYNPTP---AVPTNPQ 270

  Fly   264 KWIV---------ETG----------------------------------QVLVQKLGC-----Q 280
            ..:.         .||                                  |.|.|.| |     |
Worm   271 VQVTTPRPMYDQSNTGYGNAGYQNNYGYQPQPITSTSSYNSANAQYDDPSQQLAQTL-CNISPDQ 334

  Fly   281 FEEAQRRQLMGCLRRKSREDLLRAYESVYNHGNGSSQLGVILPEG--LP--LEQRLRNKTLPPVL 341
            :...|.:.:..|::..:.:..      |.....|.:...:|:.:.  ||  ::.....:...|::
Worm   335 WNNGQTQNIQNCMKNYTVDFF------VNQQPGGPNATWMIVRDTSFLPGSIDSLTTRRPNIPII 393

  Fly   342 LGITSNEGA----------------FLQDYWLDVAREGQVALHKYINHTLLPNVMR--------- 381
            :|...:|.|                .|.|:..|.||:.:      :|.|....|..
Worm   394 IGTVQDEDADYAFKLINTGKGSDPNNLDDWIFDFARKNK------LNQTQANQVSNIISNNYGVN 452

  Fly   382 --ALESVGEESSTQLAAIRWRYFNGKGEGVSHLLAGMQRLLSESLYELPYSRILELLNGTTSYAY 444
              ||...|.:.::|...      :|.|:.|::.....|...:.:.|:  |.:..:..|...:|
Worm   453 TGALGQQGAQVNSQYQG------SGTGQQVNNQYQNTQGQQTNNQYQ--YDQGGQQTNNQGAY-- 507

  Fly   445 VFDHSHSMDMRGRRNLFGGASHSSDLPLLLGPSLFQQIARRRFSGEEEQLCRKIRGAFANFIKNG 509
                            :||        ::.|    ||...:. ..:.:|..::.:|::.|...|.
Worm   508 ----------------YGG--------VVAG----QQTTYQN-QNQNQQGVQRDQGSYQNQYSNQ 543

  Fly   510 NP----TPGRIYDGWLPYNKENPFVYSLGEQAKT-PQTGSVDEAEVDKLLRGETGAPGLDRSLSR 569
            |.    .||. |.........|..|||  .|..| .||.:          :.:.|:.|.:::.::
Worm   544 NQQVYNNPGS-YQQQQQQQSNNQQVYS--NQGNTYSQTNN----------QNQYGSSGQNQNQNQ 595

  Fly   570 --SNRHDTYRAAPSNSYTASNQLDSGYSNHLQMVYGF 604
              ||::..     :..||...|    ||| :...||:
Worm   596 QTSNQYQN-----NGVYTNVTQ----YSN-VNNNYGY 622

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12869	NP_001369085.1	COesterase	27..541	CDD:395084	143/620 (23%)
cest-12	NP_499576.4	Abhydrolase	37..>400	CDD:389770	100/388 (26%)
cest-12	NP_499576.4	Abhydrolase	<678..774	CDD:389770
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.000