DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12869 and Nlgn3

DIOPT Version :9

Sequence 1:	NP_001369085.1	Gene:	CG12869 / 36616	FlyBaseID:	FBgn0033943	Length:	839	Species:	Drosophila melanogaster
Sequence 2:	NP_599163.2	Gene:	Nlgn3 / 171297	RGDID:	621119	Length:	848	Species:	Rattus norvegicus

Alignment Length:	776	Identity:	176/776 - (22%)
Similarity:	284/776 - (36%)	Gaps:	211/776 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ILRLLPILIHLSPYISAQ--QTHIKLEQGDLIGLKV-FPDGTRGAVYAFLGIPYAQAPINELRFA 71
            ||..|.:::..|....|.  .||.    |.|.|.:| .|....|.|..:||:|||..||.|.||.
  Rat    25 ILWFLSLVLRASTQAPAPTVNTHF----GKLRGARVPLPSEILGPVDQYLGVPYAAPPIGEKRFL 85

  Fly    72 PAKPSSSFNRTLQATTMQPLCPQLANTIYDE---------SSDGSMPRSVSTDEDCLYLNIWTPE 127
            |.:|..|::....||...|:|||..:|...|         :.|.........:|||||||::.|.
  Rat    86 PPEPPPSWSGIRNATHFPPVCPQNIHTAVPEVMLPVWFTANLDIVATYIQEPNEDCLYLNVYVPT 150

  Fly   128 SGMR------------------------------------------YGKLPIVVIVTGEEFAYDW 150
            ..::                                          .|..|::|.:.|..: .:.
  Rat   151 EDVKRISKECARKPNKKICRKGGSGAKKQGEDLADNDGDEDEDIRDSGAKPVMVYIHGGSY-MEG 214

  Fly   151 PRNRINGLDLAGEG-IVVVSVQYRNNIYGWLSLGEQHRNVPGNYGLSDVQMALRWIRRNADAFGG 214
            ..|.|:|..||..| ::|:::.||..:.|:||.|:|  ...|||||.|...||||:..|...|||
  Rat   215 TGNMIDGSVLASYGNVIVITLNYRVGVLGFLSTGDQ--AAKGNYGLLDQIQALRWVSENIAFFGG 277

  Fly   215 NPDHITLLGHGSGGAPLALVATLEDSSQVKQLVLMSPGPIMRALGQNHQKWIVETGQVLVQKLGC 279
            :|..||:.|.|.|.:.::|:.....|..:.|..::..|..:.:...|:|.  |:...:|..|:||
  Rat   278 DPRRITVFGSGIGASCVSLLTLSHHSEGLFQRAIIQSGSALSSWAVNYQP--VKYTSLLADKVGC 340

  Fly   280 QFEEAQRRQLMGCLRRKSREDLLR--AYESVYNHGNGSSQLGVILPEGLPLEQRLRNKTLPPVLL 342
            ...:..  .::.|||:||.::|:.  ...:.|:...|....|.::|:.            |.:|:
  Rat   341 NVLDTV--DMVDCLRQKSAKELVEQDIQPARYHVAFGPVIDGDVIPDD------------PEILM 391

  Fly   343 GITSNEGAFLQ-DYWLDVAR-------EGQVALHKYINHT----LLPNVMRALESVGEESSTQLA 395
                .:|.||. |..|.|.:       ||.|.....::.|    .:.|.:..|....|...|...
  Rat   392 ----EQGEFLNYDIMLGVNQGEGLKFVEGVVDPEDGVSGTDFDYSVSNFVDNLYGYPEGKDTLRE 452

  Fly   396 AIRWRYFN-GKGEGVSHLLAGMQRLLSESLYELP--YSRILELLNGTTSYAYVFDHSHSMDMRGR 457
            .|::.|.: ...:........:..|.::..:..|  .:..|....|:.:|.|.|.| |...:  .
  Rat   453 TIKFMYTDWADRDNPETRRKTLVALFTDHQWVEPSVVTADLHARYGSPTYFYAFYH-HCQSL--M 514

  Fly   458 RNLFGGASHSSDLPL-----LLGPS-LFQQIARRRFSGEEEQLCRKIRGAFANFIKNGNP----- 511
            :..:..|:|..::|.     ::||: ||.    ..||..:..|...:...:.||.|.|:|
  Rat   515 KPAWSDAAHGDEVPYVFGVPMVGPTDLFP----CNFSKNDVMLSAVVMTYWTNFAKTGDPNKPVP 575

  Fly   512 -------TPGRIYD--GWLPYNKEN----------------------------PFVYSLGEQ--- 536
                   |....::  .|..||..:                            |.:|:|.:.
  Rat   576 QDTKFIHTKANRFEEVAWSKYNPRDQLYLHIGLKPRVRDHYRATKVAFWKHLVPHLYNLHDMFHY 640

  Fly   537 ----AKTPQTGSVDEAEVDKLLRGETGAPGLDRSLSRSNRHDTYRAAPSNSYTASN-------QL 590
                .|.|...:...:.:.:...|:|.:              |.|.|.|.:|:..|       ..
  Rat   641 TSTTTKVPPPDTTHSSHITRRPNGKTWS--------------TKRPAISPAYSNENAPGSWNGDQ 691

  Fly   591 DSG---------YSNHLQMVYG------FWQVLM--------------PLEREEDLRGGGA 622
            |:|         ||..|.:...      |..||.              ||.:....||.||
  Rat   692 DAGPLLVENPRDYSTELSVTIAVGASLLFLNVLAFAALYYRKDKRRQEPLRQPSPQRGTGA 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12869	NP_001369085.1	COesterase	27..541	CDD:395084	148/640 (23%)
Nlgn3	NP_599163.2	COesterase	40..624	CDD:395084	145/617 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	169..195		0/25 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	645..691		10/59 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810