Protein Alignment CG12869 and Ces3b

DIOPT Version :9

• Sequence 1: NP_001369085.1
• Gene: CG12869 / 36616
• FlyBaseID: FBgn0033943
• Length: 839
• Species: Drosophila melanogaster
• Sequence 2: NP_653094.2
• Gene: Ces3b / 13909
• MGIID: 3644960
• Length: 571
• Species: Mus musculus
• Alignment Length: 607
• Identity: 154/607 - (25%)
• Similarity: 256/607 - (42%)
• Gaps: 128/607 - (21%)

  Fly    28 QTHIKLEQGDLIGLKVFPDGTRGAVYAFLGIPYAQAPINELRFAPAKPSSSFNRTLQATTMQPLC 92
            |..:....|.:.|.:|....|...|..|||||:||||:..|||:...|...:.....|:...|:|
Mouse    36 QPEVDTPLGRVRGRQVGVKDTDRMVNVFLGIPFAQAPVGPLRFSAPLPPQPWEGVRDASINPPMC 100

  Fly    93 PQ-LANTIYDESSDGSMPRSVSTDEDCLYLNIWTPESGMRYGKLPIVV------IVTGEEFAYDW 150
            .| :...|..........:.....||||.|||::|.......|.|::|      ::.|...:.|
Mouse   101 LQDVEKMINSRFGLNEKIKIFPISEDCLTLNIYSPTEITAGDKRPVMVWIHGGSLLVGSSTSQD- 164

  Fly   151 PRNRINGLDLAGEG-IVVVSVQYRNNIYGWLSLGEQHRNVPGNYGLSDVQMALRWIRRNADAFGG 214
                  |..||..| :|||:||||..|:|:||.|::|  :|||.|..||..||||::.|...|||
Mouse   165 ------GSALAAYGDVVVVTVQYRLGIFGFLSTGDKH--MPGNRGFLDVVAALRWVQGNIAPFGG 221

  Fly   215 NPDHITLLGHGSGGAPLALVATLEDSSQVKQLVLMSP---GPIMRALGQNHQKWIVET------- 269
            :|:.:|:.|:.:||   .:|::|          .:||   |...||:.|:   .||.|
Mouse   222 DPNCVTIFGNSAGG---MIVSSL----------FLSPISAGLFHRAISQS---GIVTTIMMEDMK 270

  Fly   270 ----GQVLVQKLGCQFEEAQRRQLMGCLRRKSREDLLRAYESVYNHGNGSSQLGVILPEGL---- 326
                .|.....:.|  ..|...:|:.||.:|..:||::         ..:..:..|:.:..
Mouse   271 PWPEAQNFANSVAC--GSASPAELVQCLLQKEGKDLIK---------QKNVNISYIVNDSFFPQR 324

  Fly   327 PLEQRLRNKTLP--PVLLGITSNEGAFL-------QDYWLDVAREGQVALHK------YINHTLL 376
            | |:.|.::..|  |.|||:|::|..:|       .|....::||..:.:.:      .:...::
Mouse   325 P-EKLLADQQFPTVPYLLGVTNHEFGWLLLKSLNILDKLEHLSREDLLEISRPFLAIMEVPPEIM 388

  Fly   377 PNVM-RALESVGEESSTQLAAIRWRYFNGKGEGVSHLLAGMQRLLSESLYELPYSRILELLN--G 438
            |.|: ..|::..::|:|:.|                    .|.||.:..:.:|.....:.|.  |
Mouse   389 PTVIDEYLDNGSDQSATRYA--------------------FQELLGDISFIIPTLNFSKYLRDAG 433

  Fly   439 TTSYAYVFDHSHSMDMRGRRNLFGGASHSSDLPLLL-GPSLFQQIARRRF---SGEEEQLCRKIR 499
            ...:.|.|.|:.| .....:..:..|.|:|:...:. ||.|..:.:...|   :.||:||...:.
Mouse   434 CPVFLYEFQHTPS-SFAKFKPAWVKADHASENSFVFGGPFLTDESSLLAFPEATEEEKQLSLTMM 497

  Fly   500 GAFANFIKNGNPTPGRIYDGWLPYNKENPFVYSLGEQAKTPQTGSVDEAEVDKLLRG------ET 558
            ..::.|.:.|||. |:....|...|:...:: .:|.:::|..          ||.:|      ||
Mouse   498 AQWSQFARTGNPN-GKGLPPWPQLNQLEQYL-EIGLESRTGV----------KLKKGRLQFWTET 550

  Fly   559 GAPGLDRSLSRSNRHDTYRAAP 580
                |.|.:...:|....|..|
Mouse   551 ----LPRKIQEWHREQRSRKVP 568

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12869	NP_001369085.1	COesterase	27..541	CDD:395084	144/560 (26%)
Ces3b	NP_653094.2	COesterase	36..547	CDD:278561	147/580 (25%)
		Aes	75..>245	CDD:223730	60/191 (31%)
		Prevents secretion from ER. /evidence=ECO:0000255	568..571		1/1 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D233524at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920