Protein Alignment CG12869 and Ces1c

DIOPT Version :9

• Sequence 1: NP_001369085.1
• Gene: CG12869 / 36616
• FlyBaseID: FBgn0033943
• Length: 839
• Species: Drosophila melanogaster
• Sequence 2: NP_031980.2
• Gene: Ces1c / 13884
• MGIID: 95420
• Length: 554
• Species: Mus musculus
• Alignment Length: 595
• Identity: 165/595 - (27%)
• Similarity: 264/595 - (44%)
• Gaps: 109/595 - (18%)

  Fly     1 MWNALRIQQILRLLPILIH--LSPYISAQQTHIKLEQGDLIGLKVFPDGTRGAVYAFLGIPYAQA 63
            ||....:...|.:.|||.|  |.|.:..       .||.::|..:..:|....|..|||:|:|:.
Mouse     1 MWLHALVWASLAVCPILGHSLLPPVVDT-------TQGKVLGKYISLEGFEQPVAVFLGVPFAKP 58

  Fly    64 PINELRFAPAKPSSSFNRTLQATTMQPLCPQ---LANTIYDESSDGS--MPRSVSTDEDCLYLNI 123
            |:..|||||.:|:..::....||:..|:|.|   .|..:.|..|...  :|..:|  ||||||||
Mouse    59 PLGSLRFAPPQPAEPWSFVKNATSYPPMCSQDAGWAKILSDMFSTEKEILPLKIS--EDCLYLNI 121

  Fly   124 WTPESGMRYGKLPIVV------IVTGEEFAYDWPRNRINGLDL-AGEGIVVVSVQYRNNIYGWLS 181
            ::|....:..:||::|      :|.|....|       |||.| |.|.:|||::|||..|:|..|
Mouse   122 YSPADLTKSSQLPVMVWIHGGGLVIGGASPY-------NGLALSAHENVVVVTIQYRLGIWGLFS 179

  Fly   182 LGEQHRNVPGNYGLSDVQMALRWIRRNADAFGGNPDHITLLGHGSGGAPLALVATLEDSSQVKQL 246
            .|::|.  |||:...|...||||::.|...||||||.:|:.|..|||..::             :
Mouse   180 TGDEHS--PGNWAHLDQLAALRWVQDNIANFGGNPDSVTIFGESSGGISVS-------------V 229

  Fly   247 VLMSPGPIMRALGQN-HQKWIVETGQVLVQKLG--------------CQFEEAQRRQLMGCLRRK 296
            :::||      ||:: ..:.|.|:|.|:...:|              .|..:.....::.|||:|
Mouse   230 LVLSP------LGKDLFHRAISESGVVINTNVGKKNIQAVNEIIATLSQCNDTSSAAMVQCLRQK 288

  Fly   297 SREDLLRAYESVYNHGNGSSQL--GVILPEGLPLEQRLRNKTL--PPVLLGITSNEGAFLQDYWL 357
            :..:||.....:..:....|.:  ||:||:. | |:.|..|:.  .|.::|....|..::....|
Mouse   289 TESELLEISGKLVQYNISLSTMIDGVVLPKA-P-EEILAEKSFNTVPYIVGFNKQEFGWIIPMML 351

  Fly   358 -DVAREGQVALHKYINHTLLPNVMRALESVGEESSTQLAAIRWRYFNGKGEGV--SHLLAGM--- 416
             ::..||:      :|......::|...|....|.:.:.|:..:|..|..:..  |.|:..|
Mouse   352 QNLLPEGK------MNEETASLLLRRFHSELNISESMIPAVIEQYLRGVDDPAKKSELILDMFGD 410

  Fly   417 ------QRLLSESLYELPYSRILELLNGTTSYAYVFDHSHSMDMRGRRNLFGGASHSSDLPLLLG 475
                  ..|||.||.:.          |.::|.|.|.:..|.....|.....| .|..::..:.|
Mouse   411 IFFGIPAVLLSRSLRDA----------GVSTYMYEFRYRPSFVSDKRPQTVEG-DHGDEIFFVFG 464

  Fly   476 PSLFQQIARRRFSGEEEQLCRKIRGAFANFIKNGNPTPGRIYDGWLPYNKENPFVYSLGEQAKTP 540
            ..|.::.|    |.||..|.:.:...:|||.:||||. |.....|..|:::..:: .:|  |.|.
Mouse   465 APLLKEGA----SEEETNLSKMVMKFWANFARNGNPN-GEGLPHWPEYDEQEGYL-QIG--ATTQ 521

  Fly   541 QTGSVDEAEV 550
            |...:...||
Mouse   522 QAQRLKAEEV 531

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12869	NP_001369085.1	COesterase	27..541	CDD:395084	153/556 (28%)
Ces1c	NP_031980.2	Esterase_lipase	25..525	CDD:238191	154/563 (27%)
		Aes	<121..>234	CDD:223730	45/134 (34%)
		Prevents secretion from ER. /evidence=ECO:0000255	551..554

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910