Protein Alignment CG12869 and Ache

DIOPT Version :10

• Sequence 1: NP_001369085.1
• Gene: CG12869 / 36616
• FlyBaseID: FBgn0033943
• Length: 839
• Species: Drosophila melanogaster
• Sequence 2: XP_036020624.1
• Gene: Ache / 11423
• MGIID: 87876
• Length: 616
• Species: Mus musculus
• Alignment Length: 605
• Identity: 162/605 - (26%)
• Similarity: 252/605 - (41%)
• Gaps: 153/605 - (25%)

  Fly    28 QTHIKLEQGDLIGLKVFPDGTRGAVYAFLGIPYAQAPINELRFAPAKPSSSFNRTLQATTMQPLC 92
            |..:::..|.|.|:::...|  |.|.||||||:|:.|:...||.|.:|...::..|.|||.|.:|
Mouse    38 QLLVRVRGGQLRGIRLKAPG--GPVSAFLGIPFAEPPVGSRRFMPPEPKRPWSGVLDATTFQNVC 100

  Fly    93 PQLANTIYD--ESSDGSMP-RSVSTDEDCLYLNIWTPESGMRYGK----LPIVVIVTGEEF---- 146
            .|..:|:|.  |.::...| |.:|  |||||||:|||     |.:    .|:::.:.|..|
Mouse   101 YQYVDTLYPGFEGTEMWNPNRELS--EDCLYLNVWTP-----YPRPASPTPVLIWIYGGGFYSGA 158

  Fly   147 ----AYDWPRNRINGLDLAG-EGIVVVSVQYRNNIYGWLSLGEQHRNVPGNYGLSDVQMALRWIR 206
                .||       |..||. ||.|:||:.||...:|:|:| ...|..|||.||.|.::||:|::
Mouse   159 ASLDVYD-------GRFLAQVEGAVLVSMNYRVGTFGFLAL-PGSREAPGNVGLLDQRLALQWVQ 215

  Fly   207 RNADAFGGNPDHITLLGHGSGGAPLAL-VATLEDSSQVKQLVLMSPGPIMRALGQNHQKW-IVET 269
            .|..||||:|..:||.|..:|.|.:.: :.:|...|...:.||.|        |..:..| .|..
Mouse   216 ENIAAFGGDPMSVTLFGESAGAASVGMHILSLPSRSLFHRAVLQS--------GTPNGPWATVSA 272

  Fly   270 GQ------VLVQKLGCQFEEA--QRRQLMGCLRRKSREDLLRAYESVYNHGNGSSQLGVILPEGL 326
            |:      :|.:.:||....|  ...:|:.|||.:..:||:.....|                 |
Mouse   273 GEARRRATLLARLVGCPPGGAGGNDTELIACLRTRPAQDLVDHEWHV-----------------L 320

  Fly   327 PLEQRLRNKTLP-----------------------PVLLGITSNEGAFLQDYWLDVAREGQVALH 368
            |.|...|...:|                       .||:|:..:||::...|       |.....
Mouse   321 PQESIFRFSFVPVVDGDFLSDTPEALINTGDFQDLQVLVGVVKDEGSYFLVY-------GVPGFS 378

  Fly   369 KYINHTLLPNV-MRALESVGEESSTQLAA-------IRWRYFNGKGEGVSHLLAGMQRLLSESLY 425
            | .|.:|:... ..|...:|...::.|||       ..|.:    .|..:||...|..::.:...
Mouse   379 K-DNESLISRAQFLAGVRIGVPQASDLAAEAVVLHYTDWLH----PEDPTHLRDAMSAVVGDHNV 438

  Fly   426 ELPYSRILELL--NGTTSYAYVFDHSHSMDMRGRRN-----LFGGASHSSDLPLLLG----PSLF 479
            ..|.:::...|  .|...|||:|:|        |.:     |:.|..|..::..:.|    |||
Mouse   439 VCPVAQLAGRLAAQGARVYAYIFEH--------RASTLTWPLWMGVPHGYEIEFIFGLPLDPSL- 494

  Fly   480 QQIARRRFSGEEEQLCRKIRGAFANFIKNGNPTPGRIYDG----WLPYNKENPFVYSLGEQAKTP 540
                  .::.||....:::...:.||.:.|:|...|  |.    |.||........||
Mouse   495 ------NYTTEERIFAQRLMKYWTNFARTGDPNDPR--DSKSPQWPPYTTAAQQYVSL------- 544

  Fly   541 QTGSVDEAEVDKLLRGETGA 560
               ::...||.:.||.:|.|
Mouse   545 ---NLKPLEVRRGLRAQTCA 561

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12869	NP_001369085.1	COesterase	27..541	CDD:395084	156/584 (27%)
Ache	XP_036020624.1	COesterase	37..563	CDD:395084	162/605 (27%)