DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12869 and Ces1d

DIOPT Version :9

Sequence 1:	NP_001369085.1	Gene:	CG12869 / 36616	FlyBaseID:	FBgn0033943	Length:	839	Species:	Drosophila melanogaster
Sequence 2:	NP_579829.3	Gene:	Ces1d / 113902	RGDID:	70896	Length:	565	Species:	Rattus norvegicus

Alignment Length:	571	Identity:	145/571 - (25%)
Similarity:	237/571 - (41%)	Gaps:	129/571 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 QGDLIGLKVFPDGTRGAVYAFLGIPYAQAPINELRFAPAKPSSSFNRTLQATTMQPLCPQ--LAN 97
            :|.::|..|..:|....|..|||||:|:.|:..|||||.:|:..:|.....|:..|:|.|  :..
  Rat    30 KGKVLGKYVNLEGFAQPVAVFLGIPFAKPPLGSLRFAPPQPAEPWNFVKNTTSYPPMCSQDAVGG 94

  Fly    98 TIYDE---SSDGSMPRSVSTDEDCLYLNIWTPESGMRYGKLPIVV------IVTGEEFAYDWPRN 153
            .:..|   :...::|...|  |||||||::||....:..:||::|      :|.|....||
  Rat    95 QVLSELFTNRKENIPLQFS--EDCLYLNVYTPADLTKNSRLPVMVWIHGGGLVVGGASTYD---- 153

  Fly   154 RINGLDL-AGEGIVVVSVQYRNNIYGWLSLGEQHRNVPGNYGLSDVQMALRWIRRNADAFGGNPD 217
               |..| |.|.:|||::|||..|:|:.|.|::|..  ||:|..|...||.|::.|...|||||.
  Rat   154 ---GQVLSAHENVVVVTIQYRLGIWGFFSTGDEHSQ--GNWGHLDQVAALHWVQDNIANFGGNPG 213

  Fly   218 HITLLGHGSGGAPLALVATLEDSSQVKQLVLMSPGPIMRALGQNHQKWIVETGQVLVQKL----- 277
            .:|:.|..:||            ..|..|||   .|:.:.|   ..:.|.|:|.||...|
  Rat   214 SVTIFGESAGG------------FSVSALVL---SPLAKNL---FHRAISESGVVLTSALITTDS 260

  Fly   278 -----------GCQFEEAQRRQLMGCLRRKSREDLLRAYESVYNH-----GNGSSQL-------- 318
                       ||  :......::.|||:|:.::||.....:...     ||.....
  Rat   261 KPIANLIATLSGC--KTTTSAVMVHCLRQKTEDELLETSLKLNLFKLDLLGNPKESYPFLPTVID 323

  Fly   319 GVILPEGLPLEQRLRNKTL--PPVLLGITSNEGAFLQDYWLDVAREGQVALHKYINHTLLPNVMR 381
            ||:||: .| |:.|..|:.  .|.::||...|..     |                  ::|.:|.
  Rat   324 GVVLPK-TP-EEILTEKSFNTVPYIVGINKQEFG-----W------------------IIPTLMG 363

  Fly   382 ALESVGEESSTQLAAIRW------------------RYFNGKGEGVSHLLAGMQRLLSESLYELP 428
            ...|.|:.......::.|                  :||.|..:....... .|.|:::.::.:|
  Rat   364 YPLSEGKLDQKTAKSLLWKSYPTLKISEKMIPVVAEKYFGGTDDPAKRKDL-FQDLVADVMFGVP 427

  Fly   429 YSRILELLN--GTTSYAYVFDHSHSMDMRGR-RNLFGGASHSSDLPLLLGPSLFQQIARRRFSGE 490
            ...:.....  |..::.|.|::..|.....| :.:.|  .|..:|..:.|....:..|    |.|
  Rat   428 SVMVSRSHRDAGAPTFMYEFEYRPSFVSAMRPKTVIG--DHGDELFSVFGSPFLKDGA----SEE 486

  Fly   491 EEQLCRKIRGAFANFIKNGNPTPGRIYDGWLPYNKENPFVYSLGEQAKTPQ 541
            |..|.:.:...:|||.:||:|..|.: ..|..|:::..:: .:|...:..|
  Rat   487 ETNLSKMVMKYWANFARNGSPNGGGL-PHWPEYDQKEGYL-KIGASTQAAQ 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12869	NP_001369085.1	COesterase	27..541	CDD:395084	144/569 (25%)
Ces1d	NP_579829.3	COesterase	24..545	CDD:278561	145/571 (25%)
		Aes	<121..>239	CDD:223730	46/141 (33%)
		Prevents secretion from ER. /evidence=ECO:0000255	562..565
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010