Protein Alignment CG12869 and CES1

DIOPT Version :10

• Sequence 1: NP_001369085.1
• Gene: CG12869 / 36616
• FlyBaseID: FBgn0033943
• Length: 839
• Species: Drosophila melanogaster
• Sequence 2: NP_001020366.1
• Gene: CES1 / 1066
• HGNCID: 1863
• Length: 568
• Species: Homo sapiens
• Alignment Length: 576
• Identity: 165/576 - (28%)
• Similarity: 260/576 - (45%)
• Gaps: 123/576 - (21%)

  Fly    36 GDLIGLKVFPDGTRGAVYAFLGIPYAQAPINELRFAPAKPSSSFNRTLQATTMQPLCP------Q 94
            |.::|..|..:|....|..|||||:|:.|:..|||.|.:|:..::....||:..|:|.      |
Human    32 GKVLGKFVSLEGFAQPVAIFLGIPFAKPPLGPLRFTPPQPAEPWSFVKNATSYPPMCTQDPKAGQ 96

  Fly    95 LANTIYDESSDGSMPRSVSTDEDCLYLNIWTPESGMRYGKLPIVV------IVTGEEFAYDWPRN 153
            |.:.::....: ::|..:|  ||||||||:||....:..:||::|      ::.|....||
Human    97 LLSELFTNRKE-NIPLKLS--EDCLYLNIYTPADLTKKNRLPVMVWIHGGGLMVGAASTYD---- 154

  Fly   154 RINGLDLAG-EGIVVVSVQYRNNIYGWLSLGEQHRNVPGNYGLSDVQMALRWIRRNADAFGGNPD 217
               ||.||. |.:|||::|||..|:|:.|.|::|..  ||:|..|...||||::.|..:|||||.
Human   155 ---GLALAAHENVVVVTIQYRLGIWGFFSTGDEHSR--GNWGHLDQVAALRWVQDNIASFGGNPG 214

  Fly   218 HITLLGHGSGGAPLALVATLEDSSQVKQLVLMSPGPIMRALGQNHQKWIVETG----QVLVQK-- 276
            .:|:.|..:||            ..|..|||   .|:.:.|   ..:.|.|:|    .|||:|
Human   215 SVTIFGESAGG------------ESVSVLVL---SPLAKNL---FHRAISESGVALTSVLVKKGD 261

  Fly   277 -----------LGCQFEEAQRRQLMGCLRRKSREDLLRA-----YESVYNHGN-GSSQ--LGVIL 322
                       .||  :......::.|||:|:.|:||..     :.|:...|: ..||  ||.::
Human   262 VKPLAEQIAITAGC--KTTTSAVMVHCLRQKTEEELLETTLKMKFLSLDLQGDPRESQPLLGTVI 324

  Fly   323 --------PEGLPLEQRLRNKTLPPVLLGITSNEGAF-----LQDYWLDVAREGQVALHKYINHT 374
                    ||.|..|   ||....|.::||...|..:     |..|.|.   |||  |.:....:
Human   325 DGMLLLKTPEELQAE---RNFHTVPYMVGINKQEFGWLIPMQLMSYPLS---EGQ--LDQKTAMS 381

  Fly   375 LL----PNVMRALESVGEESSTQLAAIRWRYFNGKGEGVSHLLAGMQRLLSESLYELPYSRILEL 435
            ||    |.|..|.|.:.|.:.        :|..|..:.|......:. |:::.::.:|  .::..
Human   382 LLWKSYPLVCIAKELIPEATE--------KYLGGTDDTVKKKDLFLD-LIADVMFGVP--SVIVA 435

  Fly   436 LN----GTTSYAYVFDH--SHSMDMRGRRNLFGGASHSSDLPLLLGPSLFQQIARRRFSGEEEQL 494
            .|    |..:|.|.|.:  |.|.||:.:..:   ..|..:|..:.|....::.|    |.||.:|
Human   436 RNHRDAGAPTYMYEFQYRPSFSSDMKPKTVI---GDHGDELFSVFGAPFLKEGA----SEEEIRL 493

  Fly   495 CRKIRGAFANFIKNGNPTPGRIYDGWLPYNKENPFVYSLGEQAKTPQTGSVDEAEV 550
            .:.:...:|||.:||||. |.....|..||::..:: .:|  |.|.....:.:.||
Human   494 SKMVMKFWANFARNGNPN-GEGLPHWPEYNQKEGYL-QIG--ANTQAAQKLKDKEV 545

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12869	NP_001369085.1	COesterase	27..541	CDD:395084	163/565 (29%)
CES1	NP_001020366.1	COesterase	23..548	CDD:395084	165/576 (29%)