DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12869 and bche

DIOPT Version :9

Sequence 1:	NP_001369085.1	Gene:	CG12869 / 36616	FlyBaseID:	FBgn0033943	Length:	839	Species:	Drosophila melanogaster
Sequence 2:	XP_002931610.1	Gene:	bche / 100495889	XenbaseID:	XB-GENE-980117	Length:	602	Species:	Xenopus tropicalis

Alignment Length:	584	Identity:	158/584 - (27%)
Similarity:	242/584 - (41%)	Gaps:	113/584 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 IKLEQGDLIG--LKVFPDGTRGAVYAFLGIPYAQAPINELRFAPAKPSSSFNRTLQATTMQPLCP 93
            :..:.|.:.|  :.||    .|.:.||||||||:.||.:|||....|...::....|:.....|.
Frog    33 VDTKYGKVTGVQISVF----SGIITAFLGIPYAEPPIGDLRFKKPVPHKPWSEIWNASQYGNSCY 93

  Fly    94 QLANTIYDESSDGSM--PRSVSTDEDCLYLNIWTPESGMRYGKLPIVVIVTGEEFAYDWPRNRIN 156
            |..:.|:...|...|  | :....|||||||||.|....|  ...::|.:.|..|     ....:
Frog    94 QTVDQIFPGFSGAEMWNP-NTQLSEDCLYLNIWIPTPKPR--NASVMVWIYGGSF-----ETGTS 150

  Fly   157 GLDL-------AGEGIVVVSVQYRNNIYGWLSLGEQHRNVPGNYGLSDVQMALRWIRRNADAFGG 214
            .|||       ..|.::|||:.||....|:|:. ..:...|||.||.|.::||:|:..|..||||
Frog   151 SLDLYDGKFLARTERVIVVSMNYRLGALGFLAF-PGNNEAPGNVGLFDQRLALQWVYENIAAFGG 214

  Fly   215 NPDHITLLGHGSGGAPLALVATLEDSSQVKQLVLMSPGPIMRALGQN---HQKWIVET------- 269
            ||..||:.|..:|||          |.....|...|.|...||:.|:   :..|.|.|
Frog   215 NPKSITIFGESAGGA----------SVSYHMLSPKSHGFFTRAIMQSATANAPWAVITKAEASNR 269

  Fly   270 GQVLVQKLGCQFEEAQRRQLMGCLRRKSREDLLRAYESVYNHGN---------GSSQLGVILPEG 325
            ...|...|.|.:.  ...:::.|||.||.|::.....||..|.:         ......:.:||.
Frog   270 ALTLANLLNCFYR--NETEIIACLRNKSPEEIFEKAVSVLPHRSVIEVNFPPTVDGDFLIEMPEI 332

  Fly   326 LPLEQRLRNKTLPPVLLGITSNEGAFLQDYWLDVAREGQVALHK-YINHTLLPNVMRALESVGEE 389
            |....:|:.||  .:|.|:..:||::...|.|    .|....|: :||.|.....::    :...
Frog   333 LMQLGQLKKKT--QILTGVNKDEGSYFLVYGL----PGFSKDHESFINRTQFHKSVK----LAFP 387

  Fly   390 SSTQLA--AIRWRYFNGKGE-GVSHLLAGMQRLLSESLYELPYSRILELLN--------GTTSYA 443
            .:|:||  ::.:.|.|.:.| ..||....|..::.:      |:.|..||.        |..:|.
Frog   388 KATELAIDSVLFHYTNWEDEQNPSHNRDAMDDIVGD------YNFICPLLEFTKWNSELGNNAYL 446

  Fly   444 YVFDH-SHSMDMRGRRNLFGGASHSSDLPLLLGPSLFQQIARRRFSGEEEQLCRKIRGAFANFIK 507
            |.|.| |..:...|    :.|..|..::..:.|..:::   |..::..||.|.|.:...:|||.|
Frog   447 YYFHHRSSKLTWPG----WMGVMHGYEIEFVFGIPMYR---RLNYTKAEETLSRTLMRYWANFAK 504

  Fly   508 NGNPTPGRIYDG-WLPYNKENPFVYSLG-EQAKTPQ--------------------TGSVDEAE 549
            .|||...:..:. |..:..:......|| |.:||.:                    ||::||.|
Frog   505 TGNPNGAQSSENRWPVFTLDEQHYLMLGTEDSKTNRKMRAKQCRFWNNFYPKVLQITGNIDEVE 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12869	NP_001369085.1	COesterase	27..541	CDD:395084	153/554 (28%)
bche	XP_002931610.1	COesterase	32..550	CDD:365897	153/564 (27%)
bche	XP_002931610.1	AChE_tetra	565..599	CDD:370053	3/4 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010