Protein Alignment CG12869 and nlgn2

DIOPT Version :10

• Sequence 1: NP_001369085.1
• Gene: CG12869 / 36616
• FlyBaseID: FBgn0033943
• Length: 839
• Species: Drosophila melanogaster
• Sequence 2: XP_031755501.1
• Gene: nlgn2 / 100329187
• XenbaseID: XB-GENE-6034906
• Length: 810
• Species: Xenopus tropicalis
• Alignment Length: 687
• Identity: 166/687 - (24%)
• Similarity: 273/687 - (39%)
• Gaps: 121/687 - (17%)

  Fly    31 IKLEQGDLIGLKV-FPDGTRGAVYAFLGIPYAQAPINELRFAPAKPSSSFNRTLQATTMQPLCPQ 94
            :....|.|.|:|. ..:...|.|..:||||||..||.|.||...:..:|:.....|||..|:|||
 Frog    31 VNTNYGKLRGVKKDLNNEILGPVVQYLGIPYATPPIGERRFQAPEAPASWTEVRNATTFAPVCPQ 95

  Fly    95 LANTI---------YDESSDGSMPRSVSTDEDCLYLNIW--------------------TPESGM 130
            ..:.:         :.|:.|.......:..||||||||:                    ||:..:
 Frog    96 NLHGMLPGIMLPLWFTENMDVVAGYVQNQSEDCLYLNIYVPLEDGPISKSREDPRKAQHTPDEDI 160

  Fly   131 R-YGKLPIVVIVTGEEFAYDWPRNRINGLDLAGEG-IVVVSVQYRNNIYGWLSLGEQHRNVPGNY 193
            | .||.|:::.:.|..: .:...|..:|..||..| ::||::.||..|.|::|.|:|  ...|||
 Frog   161 RDSGKKPVMMFIHGGSY-MEGTGNMFDGSVLAAYGNVIVVTLNYRLGILGFMSTGDQ--AAKGNY 222

  Fly   194 GLSDVQMALRWIRRNADAFGGNPDHITLLGHGSGGAPLALVATLEDSSQVKQLVLMSPGPIMRAL 258
            ||.|...||||:..|...|||:|:.||:.|.|:|.:.::|:.....|..:.|..:...|..:.:.
 Frog   223 GLLDQIQALRWLEENIGHFGGDPERITIFGSGAGASCVSLLILSHHSEGLFQKAIAQSGTAISSW 287

  Fly   259 GQNHQKWIVETGQVLVQKLGCQFEEAQRRQLMGCLRRKSREDLL--RAYESVYNHGNGSSQLGVI 321
            ..|::.  ::..::|..|:||.::|  ..:::.|||||...||:  ....:.|:...|....|.:
 Frog   288 SVNYEP--LKYTRLLAAKVGCDYQE--NSEMVMCLRRKPYRDLVDQDIQPARYHIAFGPVVDGDV 348

  Fly   322 LPEG--LPLEQ-RLRNKTLPPVLLGITSNEG-AFLQDYWLDVAREGQVALHKYINHTLLPNVMRA 382
            :|:.  :.:|| ...|.   .:|:|:...|| .|::|   .:..|..:: :.|.:.| :.|.:..
 Frog   349 VPDDPEILMEQGEFLNY---DILMGVNQGEGLKFVED---TLESEDGIS-NSYFDFT-VSNFVDN 405

  Fly   383 LESVGEESSTQLAAIRWRYF------NGKGEGVSHLLAGMQRLLSESLYELPYSRILELLNGTTS 441
            |....|........|::.|.      ||.....: |||    |.::..:..|.....:......|
 Frog   406 LYGFAEGKDVLRETIKFMYTDWADRDNGDMRRKT-LLA----LFTDHQWVAPAIATAKFHAEYES 465

  Fly   442 YAYVFDHSHSMDMRGRRNLFGGASHSSDLPLLLGPSLF--QQIARRRFSGEEEQLCRKIRGAFAN 504
            ..|.:...|.....||.. :|.|:|..::|.:.|..:.  ..:....||..:..|...:...:.|
 Frog   466 PVYFYAFYHRCQAEGRPE-WGEAAHGDEVPYVFGVPMVGATDLFPCNFSKNDVMLSAVVMTYWTN 529

  Fly   505 FIKNGNPT-------------PGRIYD-GWLPYN---------------KEN------------- 527
            |.|.|:|.             |.|..: .|..:|               |:|
 Frog   530 FAKTGDPNQPVPQDTKFIHTKPNRFEEVVWTKFNPKEKQYLHIGLKPRVKDNYRANKVAFWLELV 594

  Fly   528 PFVYSLGEQAKTPQTGSVDEAEVDKLLRGETG-------APGLDRSLSRSNRHDTYRAAPSNSYT 585
            |.::.|.....|..|.........:...|.|.       .|.:|......|| ..|...|.:|..
 Frog   595 PHLHELNTGLHTSTTTRQPTGGTRRTSSGSTTRRPPVTFPPDIDIEEEMDNR-PRYSPFPGDSRD 658

  Fly   586 ASNQLD----SGYSNHLQMVYGFWQVLMPLEREEDLR 618
            .|.:|.    .|.|.....:..|..:....:|..:||
 Frog   659 YSTELSVTVAVGASLLFLNILAFAALYYKRDRRHELR 695

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12869	NP_001369085.1	COesterase	27..541	CDD:395084	148/597 (25%)
nlgn2	XP_031755501.1	COesterase	29..590	CDD:395084	145/579 (25%)