Protein Alignment CG12869 and nlgn4xb

DIOPT Version :10

• Sequence 1: NP_001369085.1
• Gene: CG12869 / 36616
• FlyBaseID: FBgn0033943
• Length: 839
• Species: Drosophila melanogaster
• Sequence 2: NP_001159809.1
• Gene: nlgn4xb / 100147967
• ZFINID: ZDB-GENE-100309-1
• Length: 795
• Species: Danio rerio
• Alignment Length: 706
• Identity: 172/706 - (24%)
• Similarity: 293/706 - (41%)
• Gaps: 141/706 - (19%)

  Fly    26 AQQTH---IKLEQGDLIGLKV-FPDGTRGAVYAFLGIPYAQAPINELRFAPAKPSSSFNRTLQAT 86
            ||||.   :....|.|.||:| .|....|.|..|||:|||.||..|.||...:|..|:.....||
Zfish    17 AQQTQFITVTTNYGKLRGLRVALPSEILGPVEQFLGVPYAMAPTGERRFQAPEPPLSWPGIRNAT 81

  Fly    87 TMQPLCPQ----------------------LANTIYDESSDGSMPRSVSTDEDCLYLNIWTP--- 126
            ...|:|||                      :|..::|:|            ||||||||:.|
Zfish    82 QFAPVCPQFLEDRLLLTDMLPVWFTANLDTVATYVHDQS------------EDCLYLNIYVPTEE 134

  Fly   127 ----ESGMRYGKLPIVVIVTGEEFAYDWPRNRINGLDLAGEG-IVVVSVQYRNNIYGWLSLGEQH 186
                ::|::    |::|.:.|..:. :...|.|:|..||..| ::||:|.||..:.|:||.|:|
Zfish   135 ETQDDAGLK----PVMVYIHGGSYV-EGTGNMIDGSVLASYGNVIVVTVNYRLGVLGFLSTGDQ- 193

  Fly   187 RNVPGNYGLSDVQMALRWIRRNADAFGGNPDHITLLGHGSGGAPLALVATLEDSSQVKQLVLMSP 251
             ...|||||.|...||||::.|..:|.|:|:.:|:.|.|:|.:.::|:.....|..:.|..::..
Zfish   194 -AAKGNYGLLDQIQALRWVKENIQSFSGDPERVTIFGSGAGASCVSLLTLSHYSEDLFQKAIIHS 257

  Fly   252 GPIMRALGQNHQKWIVETGQVLVQKLGCQFEEAQRRQLMGCLRRKSREDLL--RAYESVYNHGNG 314
            |..:.:...|:|.  .:..::|.:|:||  .|....:|:.||:.|:.::|:  ....:.|:...|
Zfish   258 GTALSSWAVNYQP--AKYTRLLAEKVGC--NEDDTLELIECLQSKNYKELIEQNITPAKYHIAFG 318

  Fly   315 SSQLGVILPEG--LPLEQ-RLRNKTLPPVLLGITSNEGAFLQDYWLD-----VAREGQVALHKYI 371
            ....|.::|:.  :.:|| ...|.   .::||:...||....|..||     .:.:.:.|:.:::
Zfish   319 PVIDGDVIPDDPQILMEQGEFLNY---DIMLGVNQGEGYKFVDGILDSEDRVTSNDFEFAISEFV 380

  Fly   372 NHTLLPNVMRALESVGEESSTQLAAIRWRYFN-GKGEGVSHLLAGMQRLLSESLYELPYSRILEL 435
            :|         |....|...|....|::.|.: ...|........:..|.::..:..|.....:|
Zfish   381 DH---------LYGYPEGKDTLRETIKFMYTDWADRENPEMRRKTLVALFTDHQWVAPAVATADL 436

  Fly   436 --LNGTTSYAYVFDHSHSMDMRGRRNLFGGASHSSDLPL-----LLGPSLFQQIARRRFSGEEEQ 493
              ..|:.:|.|.|.|....||   :..:..:||..:||.     ::||:   .:....||..:..
Zfish   437 HAQYGSPTYFYAFYHHCQSDM---KPAWADSSHGDELPYVFGIPMIGPT---DLFNCNFSKNDIM 495

  Fly   494 LCRKIRGAFANFIKNGNPT-------------PGRIYD-GWLPYNKENPFVYSLGEQAK------ 538
            |...:...:.||.|.|:|.             |.|..: .|..||.::.....:|.:.:
Zfish   496 LSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWSKYNPKDQLYLHIGLKPRVRDHYR 560

  Fly   539 ----------TPQTGSVDE-----AEVDKLLRGETGAPGLDRSLSR-----SNRHDTYRAAPSNS 583
                      .|...:::|     :...|:...:|......:.||.     :.||..  |.|:|:
Zfish   561 ATKIAFWLELVPHLHNINELFQYVSSTTKIPPQDTTPFSYTKRLSNKLFPSTTRHPP--APPANT 623

  Fly   584 YTASNQLDSGYSNHLQMVYGFWQVLMPLEREEDLRGGGALGQRVRLLEASADAARY 639
            ...|:|..:  |.|.....    ::...:...:|....|:|..:..|...|.||.|
Zfish   624 KQMSDQQKT--SEHADGTV----IIEARDYSTELSVTIAVGASLLFLNILAFAALY 673

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12869	NP_001369085.1	COesterase	27..541	CDD:395084	148/595 (25%)
nlgn4xb	NP_001159809.1	COesterase	24..567	CDD:395084	145/583 (25%)