DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12869 and Ces1f

DIOPT Version :9

Sequence 1:	NP_001369085.1	Gene:	CG12869 / 36616	FlyBaseID:	FBgn0033943	Length:	839	Species:	Drosophila melanogaster
Sequence 2:	NP_001096829.2	Gene:	Ces1f / 100125372	RGDID:	1642419	Length:	561	Species:	Rattus norvegicus

Alignment Length:	575	Identity:	151/575 - (26%)
Similarity:	245/575 - (42%)	Gaps:	121/575 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 QGDLIGLKVFPDGTRGAVYAFLGIPYAQAPINELRFAPAKPSSSFNRTLQATTMQPLCPQLANTI 99
            :|.::|..|..:|...:|..|||:|:|:.|:..|||||.:|:..::.....||..|:|.|
  Rat    30 KGKVLGKYVSLEGVTQSVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNTTTYPPMCSQ----- 89

  Fly   100 YDESSDGSMPRSVSTD----------EDCLYLNIWTPESGMRYGKLPIVVIVTGEEFAYDWPRNR 154
              :::.|.....:.|:          ||||||||:||....:..:||::|.:.|
  Rat    90 --DAAKGQRMNDLLTNRKEKIHLEFSEDCLYLNIYTPADFTKNSRLPVMVWIHG----------- 141

  Fly   155 INGLDLAG------------EGIVVVSVQYRNNIYGWLSLGEQHRNVPGNYGLSDVQMALRWIRR 207
             .|:.|.|            |.:|||::|||..|:|:.|.|::|..  ||:|..|...||.|::.
  Rat   142 -GGMTLGGASTYDGRVLSAYENVVVVAIQYRLGIWGFFSTGDEHSR--GNWGHLDQVAALHWVQD 203

  Fly   208 NADAFGGNPDHITLLGHGSGGAPLALVATLEDSSQVKQLVLMSPGPIMRALGQNHQKWIVETGQV 272
            |...|||:|..:|:.|..:||            ..|..|||   .|:.:.|   ..:.|.|:|.|
  Rat   204 NIANFGGDPGSVTIFGESAGG------------FSVSVLVL---SPLTKNL---FHRAISESGVV 250

  Fly   273 LVQKL----------------GCQFEEAQRRQLMGCLRRKSREDLLRAYESVYNHGNGSSQL--- 318
            .:..|                ||  |......::.|||:|:.|:||...:.: |....|||.
  Rat   251 FLPGLLTKDVRPAAKQIADMAGC--ETTTSAIIVHCLRQKTEEELLEIMKKM-NLIKLSSQRDNK 312

  Fly   319 -----------GVILPEGLPLEQRLRNKTLPPVLLGITSNEGAFLQDYWLDVAREG----QVALH 368
                       .|:||:........:|....|.::||...|..     ||.....|    .|.|.
  Rat   313 ESYHFLSTVVDNVVLPKDPKEILAEKNFNTVPYIVGINKQECG-----WLLPTMMGFVPADVELD 372

  Fly   369 KYINHTLLPNVMRALESVGEESSTQLAAIRWRYFNGKGEGVSHLLAGMQRLLSESLYELPYSRIL 433
            |.:..|||.. ..:|..:.|:...  .||. :|..|..:.:. :..|:...:.:..:.:|...:.
  Rat   373 KKMAITLLEK-FASLYGIPEDIIP--VAIE-KYRKGSDDSIK-IRDGILAFIGDVSFSIPSVMVS 432

  Fly   434 ELLN--GTTSYAYVFDHSHSMDMRGR-RNLFGGASHSSDLPLLLGPSLFQQIARRRFSGEEEQLC 495
            ....  |..:|.|.:.:..|.....| :::.|  .|:.||..:.|..:.:..|    |.||.:|.
  Rat   433 RDHRDAGAPTYMYEYQYYPSFSSPQRPKHVVG--DHADDLYSVFGAPILRDGA----SEEEIKLS 491

  Fly   496 RKIRGAFANFIKNGNPTPGRIYDGWLPYNKENPFVYSLGEQAKTPQTGSVDEAEV 550
            :.:...:|||.:||||. ||....|..|:::..:: .:|  |.|.|:..:...||
  Rat   492 KMVMKFWANFARNGNPN-GRGLPHWPQYDQKEEYL-QIG--ATTQQSQRLKAEEV 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12869	NP_001369085.1	COesterase	27..541	CDD:395084	148/564 (26%)
Ces1f	NP_001096829.2	COesterase	24..545	CDD:278561	151/575 (26%)
		Aes	<121..>234	CDD:223730	42/141 (30%)
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	558..561
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910