Protein Alignment CG12869 and nlgn1

DIOPT Version :10

• Sequence 1: NP_001369085.1
• Gene: CG12869 / 36616
• FlyBaseID: FBgn0033943
• Length: 839
• Species: Drosophila melanogaster
• Sequence 2: XP_017213657.1
• Gene: nlgn1 / 100002610
• ZFINID: ZDB-GENE-090918-1
• Length: 867
• Species: Danio rerio
• Alignment Length: 734
• Identity: 162/734 - (22%)
• Similarity: 275/734 - (37%)
• Gaps: 210/734 - (28%)

  Fly    50 GAVYAFLGIPYAQAPINELRFAPAKPSSSFNRTLQATTMQPLCPQLANTIYDESSDGSMP----- 109
            |.|..|||:|||..|..|.||.|.:|..|::....||...|:|||   |:.    :|.:|
Zfish    76 GPVIQFLGVPYAAPPTGERRFQPPEPPISWSEIRNATQFAPVCPQ---TLL----EGRLPDVMLP 133

  Fly   110 -------RSVST-----DEDCLYLNIWTP---------ESGMRYGK------------------- 134
                   ..||:     .||||:|||:.|         |...:.||
Zfish   134 VWFTNSIEVVSSYVQDQSEDCLFLNIYVPTEDVKRISKECARKPGKKICRKGGPLSKKQNDDLAD 198

  Fly   135 ---------------LPIVVIVTGEEFAYDWPRNRINGLDLAGEG-IVVVSVQYRNNIYGWLSLG 183
                           .|::|.|.|..: .:...|..:|..||..| ::|::|.||..:.|:||.|
Zfish   199 NDGAEDEDIRESGSPKPVMVFVHGGSY-MEGTGNMFDGSILASYGNVIVITVNYRLGVLGFLSTG 262

  Fly   184 EQHRNVPGNYGLSDVQMALRWIRRNADAFGGNPDHITLLGHGSGGAPLALVATLEDSSQVKQLVL 248
            :|  ...|||||.|:..||||...|...|||:|..||:.|.|:|.:.:.|: ||...|:..:...
Zfish   263 DQ--AAKGNYGLLDLIQALRWTSENIAFFGGDPLRITVFGSGAGASCVNLL-TLSHYSEGNRWSN 324

  Fly   249 MSPGPIMRALGQNH---QKWIV-----ETGQVLVQKLGCQFEEAQRRQLMGCLRRKSREDLLR-- 303
            .:.|...||:.|:.   ..|.|     :..::|.:|:||..::..  :::.||::|..::|:.
Zfish   325 STKGLFQRAIAQSGTALSSWAVSFQPAKYARMLAKKVGCNLKDTV--EMVECLQKKHYKELVEQD 387

  Fly   304 AYESVYNHGNGSSQLGVILPEG--LPLEQ-RLRNKTLPPVLLGITSNEGAFLQDYWLD-----VA 360
            ...:.|:...|....|.::|:.  :.:|| ...|.   .::||:...||....:..:|     .|
Zfish   388 IQPARYHIAFGPVIDGDVIPDDPQILMEQGEFLNY---DIMLGVNQGEGLKFVELIVDNENGVQA 449

  Fly   361 REGQVALHKYINHTLLPNVMRALESVGEESSTQLAAIRWRYFNGKGEGVSH--------LLAGMQ 417
            .:...|:..:::.         |....|........|::.|.:....   |        |||
Zfish   450 NDFDYAVSSFVDD---------LYGYPEGKDILRETIKFMYTDWADR---HNPETRRKTLLA--- 499

  Fly   418 RLLSESLYELPYSRILELLN--GTTSYAYVFDHSHSMDMRGRRNLFGGASHSSDLPL-----LLG 475
             |.::..:..|.....:|.:  |:.:|.|.|.|....:   :...:..|:|..::|.     ::|
Zfish   500 -LFTDHQWVAPAVATADLHSSFGSPTYFYAFYHHCQTE---QVPPWADAAHGDEIPYVFGLPMIG 560

  Fly   476 PSLFQQIARRRFSGEEEQLCRKIRGAFANFIKNGNPT-------------PGRIYD-GWLPYNKE 526
            |:   ::....||..:..|...:...:.||.|.|:|.             |.|..: .|..||::
Zfish   561 PT---ELFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWTRYNQK 622

  Fly   527 N----------------------------PFVYSLGEQAKTPQTGSVDEAEVDKLLRGETGAPGL 563
            :                            |.::||.|.::...|..:...||         .|..
Zfish   623 DQLYLHIGLKPRVKEHYRANKVNLWLELVPHLHSLNEVSQIISTTKLPPPEV---------TPRT 678

  Fly   564 DRSLSRSNRHDTYRAAPSNSYTASNQLDS--------GYSNHLQMVYGFWQVLMPLEREEDLRGG 620
            .:.:..:.:.......|:.:..:.||..:        .||..|.:..
Zfish   679 PKKIPVNTKRPYPTPFPTETQDSHNQNQNQPFLVDQRDYSTELSVTI------------------ 725

  Fly   621 GALGQRVRLLEASADAARY 639
             |:|..:..|...|.||.|
Zfish   726 -AVGASLLFLNILAFAALY 743

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12869	NP_001369085.1	COesterase	27..541	CDD:395084	145/626 (23%)
nlgn1	XP_017213657.1	COesterase	53..647	CDD:395084	141/608 (23%)