Protein Alignment CG12869 and nlgn2b

DIOPT Version :10

• Sequence 1: NP_001369085.1
• Gene: CG12869 / 36616
• FlyBaseID: FBgn0033943
• Length: 839
• Species: Drosophila melanogaster
• Sequence 2: NP_001159808.1
• Gene: nlgn2b / 100002407
• ZFINID: ZDB-GENE-090918-3
• Length: 860
• Species: Danio rerio
• Alignment Length: 711
• Identity: 166/711 - (23%)
• Similarity: 275/711 - (38%)
• Gaps: 141/711 - (19%)

  Fly    25 SAQQTHIKLEQGDLIGL-KVFPDGTRGAVYAFLGIPYAQAPINELRFAPAKPSSSFNRTLQATTM 88
            :|:...:....|.|.|: |...:...|.|..:||:|||..|:.|.||.|.:...|:.....||..
Zfish    48 TAKHPMVTTGYGKLRGVRKELNNEILGPVEQYLGVPYATPPVGERRFQPPEAPGSWQEIRNATQF 112

  Fly    89 QPLCPQLANTI---------YDESSDGSMPRSVSTDEDCLYLNIWTP-----------ESGMR-- 131
            .|:|||..:.:         :.::.|.:.....:..|||||||::.|           ||.|.
Zfish   113 APVCPQNIHGVLPEIMLPVWFTDNLDAAAAYVQNQSEDCLYLNVYVPTEDGPLTKKHDESSMNRP 177

  Fly   132 -------YGKLPIVVIVTGEEFAYDWPRNRINGLDLAGEG-IVVVSVQYRNNIYGWLSLGEQHRN 188
                   ..|.|:::.:.|..| .:...|..:...||..| ::||::.||..:.|:||.|:|  :
Zfish   178 RDEDIRDRRKKPVMLFIHGGSF-MEGTGNMFDASVLAAYGNVIVVTMNYRLGVLGFLSSGDQ--S 239

  Fly   189 VPGNYGLSDVQMALRWIRRNADAFGGNPDHITLLGHGSGGAPLALVATLEDSSQVKQLVLMSPGP 253
            ..|||||.|...||||:..|...|||:|:.||:.|.|:|.:.:.|:.....|..:.|..:...|.
Zfish   240 AKGNYGLLDQIQALRWLNENIGHFGGDPERITIFGSGAGASCVNLLILSHHSEGLFQRAIAQSGS 304

  Fly   254 IMRALGQNHQKWIVETGQVLVQKLGCQFEEAQRRQLMGCLRRKSREDLL--RAYESVYNHGNGSS 316
            .:.:...|::..:..  ::|.:|:||.:.:.  ..|:.||||||..:|:  ....:.|:...|..
Zfish   305 AISSWSVNYRPLMYT--KILAKKVGCSYSDT--ADLVDCLRRKSYRELVDQDVQPARYHIAFGPV 365

  Fly   317 QLGVILPEGLPLEQRLRNKTLPPVLLGITSNEG-AFLQDYWLDVAREGQVALHKYINHTLLPNVM 380
            ..|.::|:...:..:........:|||:...|| .|:.|      .||:..:........:.|.:
Zfish   366 VDGDVVPDDPEILMQQGEFLNYDILLGVNQGEGLKFVDD------NEGEEGISAASFDYTISNFV 424

  Fly   381 RALESVGEESSTQLAAIRWRYF------NGKGEGVSHLLAGMQRLLSESLYELPYSRILELLNGT 439
            ..|....|........|::.|.      ||.....: |||    |.::..:..|.....:|....
Zfish   425 DNLYGYPEGKDILRETIKFMYTDWADRDNGDMRRKT-LLA----LFTDHQWVAPAVATAKLHAEF 484

  Fly   440 TS--YAYVFDHSHSMDMRGRRNLFGGASHSSDLPLLLGPSLF--QQIARRRFSGEEEQLCRKIRG 500
            .|  |.|.|.|....:.|..   :..|:|..::|.:.|..:.  .::....||..:..|...:..
Zfish   485 QSPVYFYTFHHHCQTEARPE---WADAAHGDEIPYVFGVPMVGATELFPCNFSKNDIMLSAVVMT 546

  Fly   501 AFANFIKNGNPT-------------PGR----------------IYDGWLPYNKEN--------- 527
            .:.||.|.|:|.             |.|                ::.|..|..::|
Zfish   547 YWTNFAKTGDPNIPVPQDTKFIHTKPNRFEEVIWTKFSSKDKQYLHIGLKPRIRDNYRANKVAFW 611

  Fly   528 ----PFVYSLGEQAKTPQTGSVDEAEVDKLLRGETGAPGLDRSLSRSNRHDTYRAAPSNSYTASN 588
                |.::::.::..|..|.....|......:|...:||     :||.||.|....|.:.
Zfish   612 LELVPHLHTIHDEIPTYTTQLPPGAPHRPGWKGTAQSPG-----TRSTRHPTVSTYPPDP----- 666

  Fly   589 QLDSGYSNHLQMVYGFWQVLMPLER----------EEDLRGGGALGQRVRLLEASADAARY 639
              |...|.|            |.||          ..:|....|:|..:..|...|.||.|
Zfish   667 --DLEGSEH------------PPERFPFPSNTRDYSTELSVTVAVGASLLFLNVLAFAALY 713

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12869	NP_001369085.1	COesterase	27..541	CDD:395084	140/599 (23%)
nlgn2b	NP_001159808.1	COesterase	52..611	CDD:395084	138/579 (24%)