DRSC/TRiP Functional Genomics Resources

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Protein Alignment LamC and KRT38

DIOPT Version :10

Sequence 1:NP_001260974.1 Gene:LamC / 36615 FlyBaseID:FBgn0010397 Length:640 Species:Drosophila melanogaster
Sequence 2:NP_006762.3 Gene:KRT38 / 8687 HGNCID:6456 Length:456 Species:Homo sapiens


Alignment Length:458 Identity:119/458 - (25%)
Similarity:194/458 - (42%) Gaps:109/458 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 STPVGGASTSSRVGATSPTSPT----------------------RTSRQQEKEELQHLNDRLACY 60
            |||:|..|.     ...||..|                      .|....|||.:|.||||||.|
Human    59 STPLGRPSL-----CLPPTCHTACPLPGTCHIPGNIGICGAYGENTLNGHEKETMQFLNDRLANY 118

  Fly    61 IDRMRNLENENSRLTQELNLAQDTVNRETS---NLKAVYEKELAAARKLLDETAKEKAKLEIDIK 122
            ::::|.||.||:.|  |..|.:.:...|::   :.::.:.......:|:|...| |.|:|.:.| 
Human   119 LEKVRQLEQENAEL--EATLLERSKCHESTVCPDYQSYFHTIEELQQKILCSKA-ENARLIVQI- 179

  Fly   123 RLWEENDDLKPRLDKKTKEATVAENNARLYENRYNEVNGKYNQSLADRKKFEDQAKELALENERL 187
                                    :||:|..:.:                      .:.||:||.
Human   180 ------------------------DNAKLAADDF----------------------RIKLESERS 198

  Fly   188 RRQLDD-----LRKQLEAETLARVDLENQNQSLREE-LAFKDQVHTQELTETRS----RRQIEIS 242
            .|||.:     .:|.|:..|||:.|||.|.:||:|| |:.|.. |.||:...||    :.:||: 
Human   199 LRQLVEADKCGTQKLLDDATLAKADLEAQQESLKEEQLSLKSN-HEQEVKILRSQLGEKLRIEL- 261

  Fly   243 EIDGRLSRQYEAKLQQSLQELRDQYEGQMRINREEIELLYDNEIQNLKAAANRAAQGSALATEEV 307
            :|:..:.      |.:.|.|:|.|||..:..||:::|..:..:.:.:.......::.......|:
Human   262 DIEPTID------LNRVLGEMRAQYEAMLETNRQDVEQWFQAQSEGISLQDMSCSEELQCCQSEI 320

  Fly   308 RLMRTKIDGLNAKLQNLEDTNAGLNARIRELENLLDTERQRHNQYIASLEAELQRMRDEMAHQLQ 372
            ..:|..::.|..:.|........|...:.|.|:...||..:....|:::|.:|..:|.::..|.|
Human   321 LELRCTVNALEVERQAQHTLKDCLQNSLCEAEDRFGTELAQMQSLISNVEEQLSEIRADLERQNQ 385

  Fly   373 EYQGLMDIKVSLDLEIAAYDKLLCGEERRLNIESPGRPTTDSGISSNGSHLTASASSR--SGRVT 435
            |||.|:|:|..|:.|||.|..||..|:.:|    |..|     .|::.|.:||..:.|  .|..|
Human   386 EYQVLLDVKTRLENEIATYRNLLESEDCKL----PCNP-----CSTSPSCVTAPCAPRPSCGPCT 441

  Fly   436 PSG 438
            ..|
Human   442 TCG 444

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LamCNP_001260974.1 Filament 45..401 CDD:459643 99/368 (27%)
PRK13922 154..>221 CDD:473155 21/72 (29%)
LTD 474..574 CDD:460003
KRT38NP_006762.3 Head 1..104 9/49 (18%)
Filament 104..414 CDD:459643 99/367 (27%)
Coil 1A 105..139 18/35 (51%)
Linker 1 140..150 1/9 (11%)
Coil 1B 151..251 35/148 (24%)
Linker 12 252..267 3/15 (20%)
Coil 2 268..411 38/148 (26%)
Tail 412..456 11/42 (26%)
Blue background indicates that the domain is not in the aligned region.

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