DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LamC and Lmntd2

DIOPT Version :9

Sequence 1:	NP_001260974.1	Gene:	LamC / 36615	FlyBaseID:	FBgn0010397	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_001334494.1	Gene:	Lmntd2 / 72000	MGIID:	1919250	Length:	674	Species:	Mus musculus

Alignment Length:	600	Identity:	117/600 - (19%)
Similarity:	205/600 - (34%)	Gaps:	179/600 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 PVGGASTSSRVGATSPTSPTRTSRQQEKEELQHLNDRLACYIDRMRNLENENSRLTQELNLAQDT 84
            |.|....||.:|:...|...|.:....:....:.:..:.|.:.:               .||.:|
Mouse    18 PAGVQPDSSDLGSPVGTPVDRVAPSYSQSAKLYTSTPMGCSVKQ---------------QLAPET 67

  Fly    85 VNRETSNLKAVYEKELAAARKLLDETAKEKAKLEIDIKRLWEENDDLKPRLDKKTKEATVAENNA 149
            ::..|  |:.::|:.                :|||...|...:|.                 :||
Mouse    68 LDPRT--LRLLWEQR----------------ELEIQALRWAVQNG-----------------HNA 97

  Fly   150 RLYENRYNEVNGKYNQSL------------ADRKKFEDQAKELALENERLRRQLDDLRKQLEAET 202
            | |.:...||.|..::.|            :..|...:|.::|.||.:..:.|....::|||
Mouse    98 R-YSSILQEVAGVPSERLRGMIAPPTRNSKSQDKFLRNQVQKLTLELKAQKEQAQQEKQQLE--- 158

  Fly   203 LARVDLENQNQSLREELAFKDQVHTQELTETRS-RRQIEISEIDGRLSRQYEAKLQQSLQE-LRD 265
                      :.|::.|..|.|:..:..|..:| ..|:..|...||:.|.....::....| |||
Mouse   159 ----------EKLQQNLWAKQQLEAELQTFQKSCLLQLARSSWVGRVLRSQTGSVEVVTTEVLRD 213

  Fly   266 QYEGQMRINREEIELLYDNEIQNLKAAANRAAQGSALATEEVRLMRTKIDGLNAKLQNLEDTNAG 330
            .                    .:...:|.....|.....|:|                  |.|:.
Mouse   214 P--------------------SDFSESAEIPTSGEGFPLEDV------------------DWNSI 240

  Fly   331 LNARIRELENLLDTERQRHNQYIAS----LEAELQRMRDEMAHQLQEYQG--LMDIKVSLDLEIA 389
            .........||.....|:.:|...|    |::|......|...::.|:..  |:|...|   |..
Mouse   241 AQRYPNLFSNLNFYSDQKQSQPPTSETYTLDSEGATKHTEKPTKILEWSALPLLDTSSS---ERT 302

  Fly   390 AYDKLLCGEERRLNIESPGRPTTDSGISSNGSHLTASASSRSGRVTPSGR-----RSATPGISGS 449
            ..|...|    .:.:.|..:.||  |..|.|::|.:|...:....:.||.     :|.:|..|
Mouse   303 QSDTSSC----PIALHSGAKKTT--GHPSQGTNLASSEQMQEHTRSFSGYTEDLCKSHSPSCS-- 359

  Fly   450 SAVKRRRTVIDESED-------RTLSEYSVNAAAKGDLEIIEADVEGRFIKLHNKG-TEEINLTG 506
                  :||::...|       ..|:.:..      .|:|.......:||::.|:. .|.|:|.|
Mouse   360 ------KTVLESYTDLHHPYTRPQLNPFGC------CLKIAAVSHREKFIRVINQSQAETIDLGG 412

  Fly   507 WQLTRIAGDEELA-FKFSRGSKVLGGASVTIWSVDAGTAHDPPNNLVMKKKWPVAN--------S 562
            :.|.::..|..:. ::|..|:.:.....:|:|.  .||:.       .||:.|||:        |
Mouse   413 FVLQQLVRDFPVCMYRFPPGTLLAPQHHITVWG--EGTSR-------TKKQLPVASGQDPFQFQS 468

  Fly   563 MR---SVLANADKEV 574
            .|   :||.|...:|
Mouse   469 SRGCVTVLVNPQGQV 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LamC	NP_001260974.1	Filament	45..401	CDD:278467	65/375 (17%)
		ATP-synt_B	<67..>142	CDD:304375	11/74 (15%)
		MreC	<178..>224	CDD:302802	10/45 (22%)
		LTD	473..574	CDD:279300	27/113 (24%)
Lmntd2	NP_001334494.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40		7/21 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	255..282		6/26 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	296..339		12/51 (24%)
		LTD	395..487	CDD:395746	25/97 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	514..573
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0977
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810