DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LamC and Krt42

DIOPT Version :9

Sequence 1:	NP_001260974.1	Gene:	LamC / 36615	FlyBaseID:	FBgn0010397	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_997648.2	Gene:	Krt42 / 68239	MGIID:	1915489	Length:	452	Species:	Mus musculus

Alignment Length:	443	Identity:	128/443 - (28%)
Similarity:	194/443 - (43%)	Gaps:	123/443 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 EKEELQHLNDRLACYIDRMRNLENENSRLTQELNLAQDTVNRETSNLKAVYEKELAAAR-KLLDE 109
            |||.:|:||||||.|:||:|.||..|:.|..::...........:...:.|.|.:...| |:|..
Mouse    94 EKETMQNLNDRLATYLDRVRALEEANADLEVKIREWYKKQGPGPARDYSPYFKTIEDLRNKILAA 158

  Fly   110 TAKEKA-KLEIDIKRLWEENDDLKPRLDKKTKEATVAENNARLYENRYNEVNGKYNQSLADRKKF 173
            |....: .|:||..||..:        |.:||..|  |.|.|:....  ::||
Mouse   159 TIDNASIVLQIDNARLAAD--------DFRTKYET--ELNLRMSVEA--DING------------ 199

  Fly   174 EDQAKELALENERLRRQLDDLRKQLEAETLARVDLENQNQSLREELAFKDQVHTQELTETRSRRQ 238
                         |||.||:|       ||||.|||.|.:||:||||:..:.|.:|:...|
Mouse   200 -------------LRRVLDEL-------TLARADLEMQIESLKEELAYLRKNHEEEMNALR---- 240

  Fly   239 IEISEIDGRLSRQYEA----KLQQSLQELRDQYEGQMRINREEIELLYDNEIQNLKAAANRAAQG 299
               .::.|.::.:.:|    .|.:.|.|:|||||.....||::.|..:..:.:.|    ||..
Mouse   241 ---GQVGGDVNVEMDAAPGVDLSRILNEMRDQYEKMAEKNRKDAEEWFFTKTEEL----NREV-- 296

  Fly   300 SALATEEVRLMRTKIDGLNAKLQNLE------------------DTNAGLNARIRELENLLDTER 346
             |..||.::..||:|..|...:||||                  :|.|...|::.:|:.|
Mouse   297 -ATNTEALQSSRTEITELRRSVQNLEIELQSQLSMKASLENSLAETEARYGAQLAQLQGL----- 355

  Fly   347 QRHNQYIASLEAELQRMRDEMAHQLQEYQGLMDIKVSLDLEIAAYDKLLCGEERRLNIESPGRPT 411
                  |:|:|.:|..:|.:|..|..|||.|:|:|..|:.|||.|.:||.||
Mouse   356 ------ISSVEQQLCELRCDMERQNHEYQVLLDVKTRLEQEIATYRRLLEGE------------- 401

  Fly   412 TDSGISSNGSHLTASASSRSGRVTPSGRRSATPGISGSSAVKRRRTVIDESED 464
             |:.:::..|...||..||.|.||.                ::.||:::|.:|
Mouse   402 -DAHLATQYSSSLASQPSREGMVTS----------------RQVRTIVEEVQD 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LamC	NP_001260974.1	Filament	45..401	CDD:278467	115/378 (30%)
		ATP-synt_B	<67..>142	CDD:304375	18/76 (24%)
		MreC	<178..>224	CDD:302802	20/45 (44%)
		LTD	473..574	CDD:279300
Krt42	NP_997648.2	Head. /evidence=ECO:0000255	4..93
		Filament	93..404	CDD:278467	116/392 (30%)
		Coil 1A. /evidence=ECO:0000255	94..129		18/34 (53%)
		Linker 1. /evidence=ECO:0000255	130..147		1/16 (6%)
		Coil 1B. /evidence=ECO:0000255	148..239		40/134 (30%)
		FliD_C	<236..358	CDD:284583	34/146 (23%)
		Linker 12. /evidence=ECO:0000255	240..262		4/28 (14%)
		Coil 2. /evidence=ECO:0000255	263..401		49/155 (32%)
		Tail. /evidence=ECO:0000255	402..452		13/52 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000