DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LamC and Iffo2

DIOPT Version :9

Sequence 1:	NP_001260974.1	Gene:	LamC / 36615	FlyBaseID:	FBgn0010397	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_001128175.2	Gene:	Iffo2 / 641315	RGDID:	1624207	Length:	512	Species:	Rattus norvegicus

Alignment Length:	490	Identity:	92/490 - (18%)
Similarity:	173/490 - (35%)	Gaps:	119/490 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 GGASTSSRVGATSPTSPTRTSRQQEKEELQHLNDRLACYIDRMRNLENENSRLTQELNLAQDTVN 86
            ||....:..|.:..|:..|.........|:.||.|..|::.::..||..|..|.::|...|...:
  Rat    26 GGGGGGAGPGPSPVTAALRDDLGSNIHLLKGLNVRFRCFLAKVHELERRNRLLEKQLEQQQSERD 90

  Fly    87 RETSNLKAVYEKELAAARKLLDETA-------------------------------KEKAKLE-- 118
            |.........|:.:....:||...|                               :...:|.
  Rat    91 RRLRYKTFSREQAVQTGPELLRPPAAGGGQALGAATGVNANAVALGGLPPGGGSHPQHYGRLPGT 155

  Fly   119 ----IDIKRL--------------WEENDDLKPRLDKKTKEATVAENNARLYENRYNEVNGKYNQ 165
                ..::|.              |...|.:..::|..|.|.....|.....:...:|...::.:
  Rat   156 IWSYTQVRRTGGGGVETVQGPGVSWVHPDGVGVQIDTITPEIRALYNVLAKVKRERDEYKRRWEE 220

  Fly   166 SLA---DRKKFEDQAKELALENERLRRQLDDLRKQLEAE----------TLARVDLENQNQSLRE 217
            .||   :.:...|..:|.|.|.|.::.::::..::|:||          .:..:|.:.|.::::.
  Rat   221 ELAKCMNLQTMVDTLQEAAQEAEAIQEEMNEKIERLKAELVVFKGLMSDPMTDLDTKIQEKAMKV 285

  Fly   218 ELAFKDQVH-TQELTETRSRRQIE----------------------ISEIDGRLSRQYEAKLQQS 259
            ::....::. |.:|.:...:|..|                      |||.||.::|
  Rat   286 DMDICRRIDITAKLCDVAQQRNSEDVSKIFQVVPKKKDRKVASDDDISEQDGEVNR--------- 341

  Fly   260 LQELRDQYEGQMRINREEIELL--------YDNEIQNLKAAANRAAQGSALATEEVRLMRTKIDG 316
               ..|:..|.|.|..|...:.        :|::..:|....|   :.:.|..|:.......||
  Rat   342 ---FSDEEVGSMNITDEMKRMFNQLRETFDFDDDCDSLTWEEN---EDTLLLWEDFTNCNPTID- 399

  Fly   317 LNAKLQNLEDTNAGLNARIRELENLLDTERQRHNQYIASLEAELQRMRDEMAHQLQEYQGLMDIK 381
                ||..::.|.|  ..|.|.|:...|..:.:.:.|..:|.||...:.:|...|.||..:..:|
  Rat   400 ----LQGEQEENLG--NLIHETESFFKTRDKEYQETIGQIELELATAKSDMNRHLHEYMEMCSMK 458

  Fly   382 VSLDLEIAAYDKLLCGEERRLNIESPGR-PTTDSG 415
            ..||:::....:|:.|...| |..||.. .::|||
  Rat   459 RGLDVQMETCRRLIKGSADR-NSPSPSSVASSDSG 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LamC	NP_001260974.1	Filament	45..401	CDD:278467	80/450 (18%)
		ATP-synt_B	<67..>142	CDD:304375	17/125 (14%)
		MreC	<178..>224	CDD:302802	9/55 (16%)
		LTD	473..574	CDD:279300
Iffo2	NP_001128175.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000