DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LamC and Lmna

DIOPT Version :9

Sequence 1:NP_001260974.1 Gene:LamC / 36615 FlyBaseID:FBgn0010397 Length:640 Species:Drosophila melanogaster
Sequence 2:NP_001002016.2 Gene:Lmna / 60374 RGDID:620456 Length:665 Species:Rattus norvegicus


Alignment Length:626 Identity:221/626 - (35%)
Similarity:335/626 - (53%) Gaps:80/626 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 LNTRVSRASTSTPVGGASTSSRVGATSPTSPTRTSRQQEKEELQHLNDRLACYIDRMRNLENENS 72
            :.|...|.:|.:   ||..||     :|.||||.:|.||||:||.||||||.||||:|:||.||:
  Rat     1 METPSQRRATRS---GAQASS-----TPLSPTRITRLQEKEDLQELNDRLAVYIDRVRSLETENA 57

  Fly    73 RLTQELNLAQDTVNRETSNLKAVYEKELAAARKLLDETAKEKAKLEIDIKRLWEENDDLKPRLDK 137
            .|...:..:::.|:||.|.:||.||.||..|||.||..|||:|:|::::.::.||..:||.|..|
  Rat    58 GLRLRITESEEVVSREVSGIKAAYEAELGDARKTLDSVAKERARLQLELSKVREEFKELKARNTK 122

  Fly   138 KTKEATVAENNARLYENRYNEVNGKYNQSLADRKKFEDQAKELALENERLRRQLDDLRKQLEAET 202
            |..:...|:...:..|...|......:.:|::::..|.:..:|..:..:|...|.:.:|||:.|.
  Rat   123 KEGDLLAAQARLKDLEALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEM 187

  Fly   203 LARVDLENQNQSLREELAFKDQVHTQELTETRSRRQIEISEIDGRLSRQYEAKLQQSLQELRDQY 267
            |.|||.||:.|:|:|||.|:..::::||.||:.|.:..:.|||....|::|::|..:|||||.|:
  Rat   188 LRRVDAENRLQTLKEELDFQKNIYSEELRETKRRHETRLVEIDNGKQREFESRLADALQELRAQH 252

  Fly   268 EGQMRINREEIELLYDNEIQNLKAAANRAAQGSALATEEVRLMRTKIDGLNAKLQNLEDTNAGLN 332
            |.|:...::|:|..|..::.|.:.:|.|.:.....|.||::..|.:||.|:|:|..|:...|...
  Rat   253 EDQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKE 317

  Fly   333 ARIRELENLLDTERQRHNQYIASLEAELQRMRDEMAHQLQEYQGLMDIKVSLDLEIAAYDKLLCG 397
            |::|:||:.|..||....:.:|..|.|:..||..|..||.|||.|:|||::||:||.||.|||.|
  Rat   318 AKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEG 382

  Fly   398 EERRLNIESPGRPTTDSGISSNGSHLTASASSRSGRVTPSGRRSATPGISGSSAVKRRRTVIDES 462
            ||.||                   .|:.|.:|:..|...|...|.:.|  |.|..|:|:  ::.|
  Rat   383 EEERL-------------------RLSPSPTSQRSRGRASSHSSQSQG--GGSVTKKRK--LESS 424

  Fly   463 EDRTLSEYSVNAAAKGDLEIIEADVEGRFIKLHNKGTEEINLTGWQLTRIAGDEEL-AFKFSRGS 526
            |.|  |.:|.:|...|.:.:.|.|.||:|::|.||..|:.::..||:.|..||:.| .::|....
  Rat   425 ESR--SSFSQHARTSGRVAVEEVDEEGKFVRLRNKSNEDQSMGNWQIRRQNGDDPLMTYRFPPKF 487

  Fly   527 KVLGGASVTIWSVDAGTAHDPPNNLVMKKK--WPVANSMRSVLANADKE-------VRVLSI--- 579
            .:..|..||||:..||..|.||.:||.|.:  |...:|:|:.|.||..|       ||.|::   
  Rat   488 TLKAGQVVTIWASGAGATHSPPTDLVWKAQNTWGCGSSLRTALINATGEEVAMRKLVRSLTMVED 552

  Fly   580 ----------------------------YN------TCGTC 586
                                        ||      .||||
  Rat   553 NDDEEEDGDELLHHHRGSHCSSSGDPAEYNLRSRTVLCGTC 593

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LamCNP_001260974.1 Filament 45..401 CDD:278467 143/355 (40%)
ATP-synt_B <67..>142 CDD:304375 32/74 (43%)
MreC <178..>224 CDD:302802 19/45 (42%)
LTD 473..574 CDD:279300 38/110 (35%)
LmnaNP_001002016.2 Interaction with MLIP. /evidence=ECO:0000250 1..130 62/136 (46%)
Head 1..33 15/39 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..27 12/33 (36%)
Filament 30..386 CDD:365827 143/355 (40%)
Coil 1A 34..70 18/35 (51%)
Linker 1 71..80 4/8 (50%)
Coil 1B 81..218 47/136 (35%)
Linker 2 219..242 6/22 (27%)
Coil 2 243..383 56/139 (40%)
Tail 384..665 66/235 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 384..442 21/82 (26%)
Nuclear localization signal. /evidence=ECO:0000255 417..422 2/6 (33%)
LTD 434..541 CDD:395746 38/106 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 552..577 0/24 (0%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 270 1.000 Domainoid score I1753
eggNOG 1 0.900 - - E1_KOG0977
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 392 1.000 Inparanoid score I1917
OMA 1 1.010 - - QHG48052
OrthoDB 1 1.010 - - D204815at33208
OrthoFinder 1 1.000 - - FOG0001052
OrthoInspector 1 1.000 - - mtm9150
orthoMCL 1 0.900 - - OOG6_103212
Panther 1 1.100 - - O PTHR45721
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X632
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1413.840

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