DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LamC and krt15

DIOPT Version :9

Sequence 1:	NP_001260974.1	Gene:	LamC / 36615	FlyBaseID:	FBgn0010397	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_998688.2	Gene:	krt15 / 406844	ZFINID:	ZDB-GENE-040426-2931	Length:	460	Species:	Danio rerio

Alignment Length:	422	Identity:	124/422 - (29%)
Similarity:	196/422 - (46%)	Gaps:	95/422 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 EKEELQHLNDRLACYIDRMRNLENENSRLTQELNLAQDTVNRETSNLKAVYEKELAAARKLLDET 110
            ||..:|:||||||.|:|::|:||..|:.|  ||.:.| .:..:||                  ..
Zfish   107 EKATMQNLNDRLATYLDKVRSLEKANADL--ELKIRQ-FLESKTS------------------PA 150

  Fly   111 AKEKAKLEIDIKRLWEENDDLKPRLDKKTK---EATVAENNARLYENRYNEVNGKYNQSLADRKK 172
            |::.:..:..||       ||:.::...|:   ...:|.:||:|..:.:..   ||...|..|:.
Zfish   151 ARDYSAYQATIK-------DLQDKIQDATRVNGGVYLAVDNAKLAADDFKT---KYENELTMRQS 205

  Fly   173 FEDQAKELALENERLRRQLDDLRKQLEAETLARVDLENQNQSLREELAFKDQVHTQELTETRSRR 237
            .|   .::|    .|:|.||:|       ||||.|||.|.:.|:|||.|..:.|.:||...||:.
Zfish   206 VE---ADIA----GLKRLLDEL-------TLARSDLEMQIEGLKEELIFLKKNHEEELAAMRSQM 256

  Fly   238 QIEIS-EIDGRLSRQYEAKLQQSLQELRDQYEGQMRINREEIELLYDNEIQNLK---AAANRAAQ 298
            ...:: |:|.    ..:..|...:.|:|:|||.....|:.::|..:..:.:.|.   ||:....|
Zfish   257 SGSVNVEVDA----APQVDLNHVMAEIREQYENVAAKNQRDLENWFQTKSETLTKEVAASTETIQ 317

  Fly   299 GSALATEEVRLMRTKIDGLNAKLQ-------NLEDTNAGLNARI-RELENLLDTERQRHNQYIAS 355
            .|  .||...|.|| :.||..:||       :||.|.|...||. |:|.||        ...:.:
Zfish   318 VS--KTELTELRRT-LQGLEIELQSELSKKASLEGTLADTEARFSRQLMNL--------QTQVTN 371

  Fly   356 LEAELQRMRDEMAHQLQEYQGLMDIKVSLDLEIAAYDKLLCGEERRLNIESPGRPTTDSGISSNG 420
            ||.::.::|.:|..|.|||:.|:|||..|::|||.|.:||.|....:        .:..|....|
Zfish   372 LEEQIVQLRADMDRQGQEYKMLLDIKTRLEMEIAEYRRLLDGGASSM--------ISTGGGGGGG 428

  Fly   421 SHLTASASSRS------------GRVTPSGRR 440
            |..|:|:|::|            |:|..|.::
Zfish   429 SSSTSSSSTKSITVKTIVEDIVDGQVVSSSKK 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LamC	NP_001260974.1	Filament	45..401	CDD:278467	114/369 (31%)
		ATP-synt_B	<67..>142	CDD:304375	15/77 (19%)
		MreC	<178..>224	CDD:302802	19/45 (42%)
		LTD	473..574	CDD:279300
krt15	NP_998688.2	Filament	106..413	CDD:278467	113/365 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000