Protein Alignment LamC and LMNB1

DIOPT Version :10

• Sequence 1: NP_001260974.1
• Gene: LamC / 36615
• FlyBaseID: FBgn0010397
• Length: 640
• Species: Drosophila melanogaster
• Sequence 2: NP_005564.1
• Gene: LMNB1 / 4001
• HGNCID: 6637
• Length: 586
• Species: Homo sapiens
• Alignment Length: 562
• Identity: 207/562 - (36%)
• Similarity: 326/562 - (58%)
• Gaps: 30/562 - (5%)

  Fly    16 STSTPVGGASTSSRVGATSPTSPTRTSRQQEKEELQHLNDRLACYIDRMRNLENENSRLTQELNL 80
            :|:|||.....|...|.|:|.||||.||.||||||:.||||||.|||::|:||.|||.|..::..
Human     2 ATATPVPPRMGSRAGGPTTPLSPTRLSRLQEKEELRELNDRLAVYIDKVRSLETENSALQLQVTE 66

  Fly    81 AQDTVNRETSNLKAVYEKELAAARKLLDETAKEKAKLEIDIKRLWEENDDLKPRLDKKTKEATVA 145
            .::...||.:.|||:||.|||.||:.||:||:|:|||:|::.:...|:|.|.....||..:...|
Human    67 REEVRGRELTGLKALYETELADARRALDDTARERAKLQIELGKCKAEHDQLLLNYAKKESDLNGA 131

  Fly   146 ENNARLYENRYNEVNGKYNQSLADRKKFEDQAKELALENERLRRQLDDLRKQLEAETLARVDLEN 210
            :...|.||...|..:.....:|.|:|..|...::|..:..:|...|...:|||..|||.:|||||
Human   132 QIKLREYEAALNSKDAALATALGDKKSLEGDLEDLKDQIAQLEASLAAAKKQLADETLLKVDLEN 196

  Fly   211 QNQSLREELAFKDQVHTQELTETRSRRQIEISEIDGRLSRQYEAKLQQSLQELRDQYEGQMRINR 275
            :.|||.|:|.|:..::.:|:.|||.:.:..:.|:|.....:||.||.|:|.|:|:|::.|:|:.:
Human   197 RCQSLTEDLEFRKSMYEEEINETRRKHETRLVEVDSGRQIEYEYKLAQALHEMREQHDAQVRLYK 261

  Fly   276 EEIELLYDNEIQNLKAAANRAAQGSALATEEVRLMRTKIDGLNAKLQNLEDTNAGLNARIRELEN 340
            ||:|..|..:::|.:.::.........|.||:...|.:|:.|:::|.||:..:.....||:|||:
Human   262 EELEQTYHAKLENARLSSEMNTSTVNSAREELMESRMRIESLSSQLSNLQKESRACLERIQELED 326

  Fly   341 LLDTERQRHNQYIASLEAELQRMRDEMAHQLQEYQGLMDIKVSLDLEIAAYDKLLCGEERRLNIE 405
            ||..|:....:.:...|.|:..:||:|..||.:|:.|:|:|::||:||:||.|||.|||.||.:
Human   327 LLAKEKDNSRRMLTDKEREMAEIRDQMQQQLNDYEQLLDVKLALDMEISAYRKLLEGEEERLKL- 390

  Fly   406 SPGRPTTDSGISSNGSHLTAS--ASSRSGRVTPSGRRSATPGISGSSAVKRRRTVIDESEDRTLS 468
            ||          |..|.:|.|  :||||.|.|..               ||:|..::|||..:..
Human   391 SP----------SPSSRVTVSRASSSRSVRTTRG---------------KRKRVDVEESEASSSV 430

  Fly   469 EYSVNAAAKGDLEIIEADVEGRFIKLHNKGTEEINLTGWQLTRIAGDEELAFKFSRGSKVLGGAS 533
            ..|.:|:|.|::.|.|.||:|:||:|.|...::..:.||::.|..||..:::|::....:..|.:
Human   431 SISHSASATGNVCIEEIDVDGKFIRLKNTSEQDQPMGGWEMIRKIGDTSVSYKYTSRYVLKAGQT 495

  Fly   534 VTIWSVDAGTAHDPPNNLVMKKK--WPVANSMRSVLANADKE 573
            ||||:.:||....||.:|:.|.:  |.....::.:|.|:..|
Human   496 VTIWAANAGVTASPPTDLIWKNQNSWGTGEDVKVILKNSQGE 537

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LamC	NP_001260974.1	Filament	45..401	CDD:459643	139/355 (39%)
		PRK13922	154..>221	CDD:473155	24/66 (36%)
		LTD	474..574	CDD:460003	33/102 (32%)
LMNB1	NP_005564.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..31		14/28 (50%)
		Head	2..34		16/31 (52%)
		Filament	31..387	CDD:459643	139/355 (39%)
		Coil 1A	35..69		18/33 (55%)
		Linker 1	70..81		4/10 (40%)
		Coil 1B	82..215		50/132 (38%)
		Linker 2	216..243		8/26 (31%)
		Coil 2	244..386		51/141 (36%)
		Tail	387..586		54/177 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	388..432		19/69 (28%)
		Nuclear localization signal. /evidence=ECO:0000255	415..420		3/4 (75%)
		LTD	439..543	CDD:460003	31/99 (31%)