DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LamC and LMNA

DIOPT Version :10

Sequence 1:NP_001260974.1 Gene:LamC / 36615 FlyBaseID:FBgn0010397 Length:640 Species:Drosophila melanogaster
Sequence 2:NP_001393914.1 Gene:LMNA / 4000 HGNCID:6636 Length:686 Species:Homo sapiens


Alignment Length:624 Identity:219/624 - (35%)
Similarity:335/624 - (53%) Gaps:78/624 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 LNTRVSRASTSTPVGGASTSSRVGATSPTSPTRTSRQQEKEELQHLNDRLACYIDRMRNLENENS 72
            :.|...|.:|.:   ||..||     :|.||||.:|.||||:||.||||||.||||:|:||.||:
Human     1 METPSQRRATRS---GAQASS-----TPLSPTRITRLQEKEDLQELNDRLAVYIDRVRSLETENA 57

  Fly    73 RLTQELNLAQDTVNRETSNLKAVYEKELAAARKLLDETAKEKAKLEIDIKRLWEENDDLKPRLDK 137
            .|...:..:::.|:||.|.:||.||.||..|||.||..|||:|:|::::.::.||..:||.|..|
Human    58 GLRLRITESEEVVSREVSGIKAAYEAELGDARKTLDSVAKERARLQLELSKVREEFKELKARNTK 122

  Fly   138 KTKEATVAENNARLYENRYNEVNGKYNQSLADRKKFEDQAKELALENERLRRQLDDLRKQLEAET 202
            |..:...|:...:..|...|......:.:|::::..|.:..:|..:..:|...|.:.:|||:.|.
Human   123 KEGDLIAAQARLKDLEALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEM 187

  Fly   203 LARVDLENQNQSLREELAFKDQVHTQELTETRSRRQIEISEIDGRLSRQYEAKLQQSLQELRDQY 267
            |.|||.||:.|:::|||.|:..::::||.||:.|.:..:.|||....|::|::|..:|||||.|:
Human   188 LRRVDAENRLQTMKEELDFQKNIYSEELRETKRRHETRLVEIDNGKQREFESRLADALQELRAQH 252

  Fly   268 EGQMRINREEIELLYDNEIQNLKAAANRAAQGSALATEEVRLMRTKIDGLNAKLQNLEDTNAGLN 332
            |.|:...::|:|..|..::.|.:.:|.|.:.....|.||::..|.:||.|:|:|..|:...|...
Human   253 EDQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKE 317

  Fly   333 ARIRELENLLDTERQRHNQYIASLEAELQRMRDEMAHQLQEYQGLMDIKVSLDLEIAAYDKLLCG 397
            |::|:||:.|..||....:.:|..|.|:..||..|..||.|||.|:|||::||:||.||.|||.|
Human   318 AKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEG 382

  Fly   398 EERRLNIESPGRPTTDSGISSNGSHLTASASSRSGRVTPSGRRSATPGISGSSAVKRRRTVIDES 462
            ||.||                   .|:.|.:|:..|...|...|.|.|  |.|..|:|:  ::.:
Human   383 EEERL-------------------RLSPSPTSQRSRGRASSHSSQTQG--GGSVTKKRK--LEST 424

  Fly   463 EDRTLSEYSVNAAAKGDLEIIEADVEGRFIKLHNKGTEEINLTGWQLTRIAGDEE-LAFKFSRGS 526
            |.|  |.:|.:|...|.:.:.|.|.||:|::|.||..|:.::..||:.|..||:. |.::|....
Human   425 ESR--SSFSQHARTSGRVAVEEVDEEGKFVRLRNKSNEDQSMGNWQIKRQNGDDPLLTYRFPPKF 487

  Fly   527 KVLGGASVTIWSVDAGTAHDPPNNLVMKKK--WPVANSMRSVLANADKE-------VRVLSI--- 579
            .:..|..||||:..||..|.||.:||.|.:  |...||:|:.|.|:..|       ||.:::   
Human   488 TLKAGQVVTIWAAGAGATHSPPTDLVWKAQNTWGCGNSLRTALINSTGEEVAMRKLVRSVTVVED 552

  Fly   580 --------------------------YN------TCGTC 586
                                      ||      .||||
Human   553 DEDEDGDDLLHHHHGSHCSSSGDPAEYNLRSRTVLCGTC 591

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LamCNP_001260974.1 Filament 45..401 CDD:459643 142/355 (40%)
PRK13922 154..>221 CDD:473155 20/66 (30%)
LTD 474..574 CDD:460003 38/109 (35%)
LMNANP_001393914.1 Interaction with MLIP. /evidence=ECO:0000269|PubMed:21498514 1..130 62/136 (46%)
Head 1..33 15/39 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..25 10/31 (32%)
Filament 30..386 CDD:459643 142/355 (40%)
Coil 1A 34..70 18/35 (51%)
Linker 1 71..80 4/8 (50%)
Coil 1B 81..218 46/136 (34%)
Linker 2 219..242 6/22 (27%)
Coil 2 243..383 56/139 (40%)
Necessary and sufficient for the interaction with IFFO1. /evidence=ECO:0000269|PubMed:31548606 259..331 22/71 (31%)
Tail 384..664 65/233 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 384..442 21/82 (26%)
Nuclear localization signal. /evidence=ECO:0000255 417..422 2/6 (33%)
LTD 434..541 CDD:460003 38/106 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 552..576 0/23 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 598..619
Blue background indicates that the domain is not in the aligned region.

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