DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LamC and lmnb1

DIOPT Version :9

Sequence 1:	NP_001260974.1	Gene:	LamC / 36615	FlyBaseID:	FBgn0010397	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_989198.1	Gene:	lmnb1 / 394806	XenbaseID:	XB-GENE-489658	Length:	584	Species:	Xenopus tropicalis

Alignment Length:	573	Identity:	208/573 - (36%)
Similarity:	335/573 - (58%)	Gaps:	32/573 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 STSTPVGGASTSSRVGATSPTSPTRTSRQQEKEELQHLNDRLACYIDRMRNLENENSRLTQELNL 80
            :|:||.|..|:..|....:|.||||.||.|||.:||.||||||.|||::|:||:|||.|..::..
Frog     2 ATATPSGPRSSGRRSSMNTPLSPTRISRLQEKVDLQELNDRLAVYIDKVRSLESENSLLHVQVTE 66

  Fly    81 AQDTVNRETSNLKAVYEKELAAARKLLDETAKEKAKLEIDIKRLWEENDDLKPRLDKKTKEATVA 145
            .::..:||.|.:|.:||.|||.||:.||:||:|:|:|::::.::..|::||:....||..|...|
Frog    67 REEVRSREVSGIKELYETELADARRSLDDTARERARLQLELSKISVEHEDLRASFSKKESELESA 131

  Fly   146 ENNARLYENRYNEVNGKYNQSLADRKKFEDQAKELALENERLRRQLDDLRKQLEAETLARVDLEN 210
            :...|..|...|..|.....:.::.|..:.:.::|..|..:|...|...:||||.|.|.:|||||
Frog   132 QARFRETEALLNSKNAALATTQSENKSLQGEVEDLKAEIGQLESALALAKKQLEEEILIKVDLEN 196

  Fly   211 QNQSLREELAFKDQVHTQELTETRSRRQIEISEIDGRLSRQYEAKLQQSLQELRDQYEGQMRINR 275
            :.|||.|||.|:..|:.:|:.|||.|.:..:.|:|.....:||.||.|:|.::|:|::.|:.:.:
Frog   197 RCQSLIEELDFRKNVYEEEIKETRRRHETRLVEVDSGKQIEYEHKLSQALADMREQHDSQVTLYK 261

  Fly   276 EEIELLYDNEIQNLKAAANRAAQGSALATEEVRLMRTKIDGLNAKLQNLEDTNAGLNARIRELEN 340
            ||:|..|.::::|.:.::...:.......||:...|.:||.|.::|..|:..:...:.|::|||:
Frog   262 EELEHTYQSKLENARLSSEMNSSAVNSTREELMESRYRIDSLTSQLSELQKESRAWHDRMQELED 326

  Fly   341 LLDTERQRHNQYIASLEAELQRMRDEMAHQLQEYQGLMDIKVSLDLEIAAYDKLLCGEERRLNIE 405
            :|..|:....:.:|..|.|:..:||:|..||.:|:.|:|:|::||:||:||.|||.|||.||.:
Frog   327 MLAKEKDNSRKMLAEREREMADIRDQMQQQLNDYEQLLDVKLALDMEISAYRKLLEGEEERLKL- 390

  Fly   406 SPGRPTTDSGISSNGSHLTAS--ASSRSGRVTPSGRRSATPGISGSSAVKRRRTVIDESEDRTLS 468
            ||..|          |.:|.|  :||||.| |..|              ||:|..::|||..:..
Frog   391 SPSPP----------SRVTVSRASSSRSVR-TAKG--------------KRKRIDVEESEASSSV 430

  Fly   469 EYSVNAAAKGDLEIIEADVEGRFIKLHNKGTEEINLTGWQLTRIAGDEELAFKFSRGSKVLGGAS 533
            ..|.:|:|.||:.|.|.||:|::|:|.|...::..|.||:|||..|:..:.|||:....:..|.:
Frog   431 SISHSASATGDVSIEEVDVDGKYIRLKNNSEQDHPLGGWELTRTIGEASVNFKFTSRYVLKAGQT 495

  Fly   534 VTIWSVDAGTAHDPPNNLVMKKK--WPVANSMRSVLANADKE--VRVLSIYNT 582
            ||||:.|||....||::|:.|.:  |.....::.:|.|:..|  .:..::|.|
Frog   496 VTIWAADAGVTASPPSDLIWKNQNSWATGEDVKVILKNSQGEDVAQRTTVYTT 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LamC	NP_001260974.1	Filament	45..401	CDD:278467	133/355 (37%)
		ATP-synt_B	<67..>142	CDD:304375	29/74 (39%)
		MreC	<178..>224	CDD:302802	22/45 (49%)
		LTD	473..574	CDD:279300	38/104 (37%)
lmnb1	NP_989198.1	Filament	31..387	CDD:365827	133/355 (37%)
lmnb1	NP_989198.1	LTD	439..543	CDD:376421	36/103 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	276	1.000	Domainoid score	I1707
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	391	1.000	Inparanoid score	I1944
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D204815at33208
OrthoFinder	1	1.000	-	-		FOG0001052
OrthoInspector	1	1.000	-	-		mtm9565
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X632
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.060