Protein Alignment LamC and KRT84

DIOPT Version :10

• Sequence 1: NP_001260974.1
• Gene: LamC / 36615
• FlyBaseID: FBgn0010397
• Length: 640
• Species: Drosophila melanogaster
• Sequence 2: NP_149034.2
• Gene: KRT84 / 3890
• HGNCID: 6461
• Length: 600
• Species: Homo sapiens
• Alignment Length: 459
• Identity: 119/459 - (25%)
• Similarity: 198/459 - (43%)
• Gaps: 78/459 - (16%)

  Fly    22 GGASTSSRVGATS-PTSPTRTS----------------------RQQEKEELQHLNDRLACYIDR 63
            ||.....|||... |.:|:.|:                      ::.|||:::.||::.|.:||:
Human   118 GGPGFGYRVGGVGVPAAPSITAVTVNKSLLTPLNLEIDPNAQRVKKDEKEQIKTLNNKFASFIDK 182

  Fly    64 MRNLENENSRLTQELNLAQDTVNRETSNLKAVYEKELAAARKLLDETAKEKAKLEIDIKRLWEEN 128
            :|.||.:|..|..:.:..|:. ....|||:.::|..:...|:.|:....::|:|:.:...|
Human   183 VRFLEQQNKLLETKWSFLQEQ-KCIRSNLEPLFESYITNLRRQLEVLVSDQARLQAERNHL---- 242

  Fly   129 DDLKPRLDKKTKEATVAENNARLYENRYNEVNGKYNQSLADRKKFEDQAKELALENERLRRQLDD 193
            .|:.....||.:|..|...||                                 |||.:.
Human   243 QDVLEGFKKKYEEEVVCRANA---------------------------------ENEFVA----- 269

  Fly   194 LRKQLEAETLARVDLENQNQSLREELAFKDQVHTQELTETRSRRQIEISEIDGRLSRQYEAKLQQ 258
            |:|.::|..:.:.|||....:|.:|:.|...::.:|:...:|  .|..:.:..::....:..|..
Human   270 LKKDVDAAFMNKSDLEANVDTLTQEIDFLKTLYMEEIQLLQS--HISETSVIVKMDNSRDLNLDG 332

  Fly   259 SLQELRDQYEGQMRINREEIELLYDNEIQNLKAAANRAAQGSALATEEVRLMRTKIDGLNAKLQN 323
            .:.|::.|||...|.:|.:.|..|..:.:.::..|.:..........|:..:...|..|.|::::
Human   333 IIAEVKAQYEEVARRSRADAEAWYQTKYEEMQVTAGQHCDNLRNIRNEINELTRLIQRLKAEIEH 397

  Fly   324 LEDTNAGLNARIRELENLLDTERQRHNQYIASLEAELQRMRDEMAHQLQEYQGLMDIKVSLDLEI 388
            .:...|.|.|.:.|.|...:.........:|.||..||:.:.:||.||.|||.||:.|:.||:||
Human   398 AKAQRAKLEAAVAEAEQQGEATLSDAKCKLADLECALQQAKQDMARQLCEYQELMNAKLGLDIEI 462

  Fly   389 AAYDKLLCGEERRLNIESPGRPTTDSGISSNG------SHLTASASSRSGRVTPSGRRS--ATPG 445
            |.|.:||.|||.|| .|..| |...|..||.|      ..|.|.::...|.||.||..|  ||.|
Human   463 ATYRRLLEGEESRL-CEGVG-PVNISVSSSRGGLVCGPEPLVAGSTLSRGGVTFSGSSSVCATSG 525

  Fly   446 ISGS 449
            :..|
Human   526 VLAS 529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LamC	NP_001260974.1	Filament	45..401	CDD:459643	90/355 (25%)
		PRK13922	154..>221	CDD:473155	11/66 (17%)
		LTD	474..574	CDD:460003
KRT84	NP_149034.2	Head	1..165		8/46 (17%)
		Keratin_2_head	16..161	CDD:465068	8/42 (19%)
		Filament	165..475	CDD:459643	90/354 (25%)
		Coil 1A	166..200		12/33 (36%)
		Linker 1	201..210		2/9 (22%)
		Coil 1B	211..311		26/141 (18%)
		Linker 12	312..328		1/15 (7%)
		Coil 2	329..472		42/142 (30%)
		Tail	473..600		22/59 (37%)