DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LamC and KRT33B

DIOPT Version :9

Sequence 1:	NP_001260974.1	Gene:	LamC / 36615	FlyBaseID:	FBgn0010397	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_002270.1	Gene:	KRT33B / 3884	HGNCID:	6451	Length:	404	Species:	Homo sapiens

Alignment Length:	399	Identity:	111/399 - (27%)
Similarity:	182/399 - (45%)	Gaps:	73/399 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 EKEELQHLNDRLACYIDRMRNLENENSRLTQELNLAQDTVNRETSNLKAVYEKELAAARKLLDE- 109
            |||.:|.||||||.|::::|.||.:|:.|.   ||.::...::...|...|:.......:|..:
Human    56 EKETMQFLNDRLASYLEKVRQLERDNAELE---NLIRERSQQQEPLLCPSYQSYFKTIEELQQKI 117

  Fly   110 --TAKEKAKLEIDIKRLWEENDDLKPRLDKKTKEATVAENNARLYENRYNEVNGKYNQSLADRKK 172
              :..|.|:|.:.|                         :||:|..:.:             |.|
Human   118 LCSKSENARLVVQI-------------------------DNAKLAADDF-------------RTK 144

  Fly   173 FE-DQAKELALENE--RLRRQLDDLRKQLEAETLARVDLENQNQSLREELAFKDQVHTQELTETR 234
            :: :|:....:|::  .|||.||:|       ||.|.|||.|.:||:|||....|.|.||:...|
Human   145 YQTEQSLRQLVESDINSLRRILDEL-------TLCRSDLEAQMESLKEELLSLKQNHEQEVNTLR 202

  Fly   235 SRRQIEISEIDGRLSRQYEA----KLQQSLQELRDQYEGQMRINREEIELLYDNEIQNL-KAAAN 294
                   .::..||:.:.:|    .|.|.|.|.|:|||..:..||.|:|..:..:.:.| |...:
Human   203 -------CQLGDRLNVEVDAAPAVDLNQVLNETRNQYEALVETNRREVEQWFATQTEELNKQVVS 260

  Fly   295 RAAQGSALATEEVRLMRTKIDGLNAKLQNLEDTNAGLNARIRELENLLDTERQRHNQYIASLEAE 359
            .:.|..:...|.:.|.|| ::.|..:||...:....|...:.|.|....::..:....|.::|::
Human   261 SSEQLQSYQAEIIELRRT-VNALEIELQAQHNLRYSLENTLTESEARYSSQLSQVQSLITNVESQ 324

  Fly   360 LQRMRDEMAHQLQEYQGLMDIKVSLDLEIAAYDKLLCGEERRLNIESPGRP--TTDSGISSNGSH 422
            |..:|.::..|.||||.|:|::..|:.||..|..||..|:.:|    |..|  ||::.....||.
Human   325 LAEIRSDLERQNQEYQVLLDVRARLECEINTYRSLLESEDCKL----PSNPCATTNACEKPIGSC 385

  Fly   423 LTASASSRS 431
            :|.....||
Human   386 VTNPCGPRS 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LamC	NP_001260974.1	Filament	45..401	CDD:278467	101/365 (28%)
		ATP-synt_B	<67..>142	CDD:304375	13/77 (17%)
		MreC	<178..>224	CDD:302802	19/47 (40%)
		LTD	473..574	CDD:279300
KRT33B	NP_002270.1	Head	1..56		111/399 (28%)
		Filament	55..366	CDD:306535	101/365 (28%)
		Coil 1A	57..91		17/36 (47%)
		Linker 1	92..102		1/9 (11%)
		Coil 1B	103..203		36/151 (24%)
		Linker 12	204..219		3/14 (21%)
		Coil 2	220..363		42/143 (29%)
		Tail	364..404		10/35 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910