DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LamC and si:dkey-222n6.2

DIOPT Version :9

Sequence 1:	NP_001260974.1	Gene:	LamC / 36615	FlyBaseID:	FBgn0010397	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	XP_003199098.1	Gene:	si:dkey-222n6.2 / 386799	ZFINID:	ZDB-GENE-031118-10	Length:	376	Species:	Danio rerio

Alignment Length:	428	Identity:	114/428 - (26%)
Similarity:	195/428 - (45%)	Gaps:	84/428 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SARRVTLNTRVSRASTS-------TPVGGASTSSRVGATSPTSPT--------RTSRQQEKEELQ 51
            |:|.|..|..:.|...|       .|..||........:|..:|.        :|.|.||.::::
Zfish     4 SSRSVGSNASIPRQGNSYFGFGNMMPASGAPIRPVSVNSSLLAPVDLQLDPELQTVRMQETQQMK 68

  Fly    52 HLNDRLACYIDRMRNLENENSRLTQELNLAQDTVNRETSNLKAVYEKELAAARKLLDETAKEKAK 116
            .||:|.|.:||::|.||.||                          |.|....:||.:..|.::|
Zfish    69 TLNNRFASFIDKVRKLEQEN--------------------------KLLETKWRLLQKETKAESK 107

  Fly   117 LEIDIKRLWEENDDLKPRLDKKTKEATVAENNARLYENRYNEVNGKYNQSLADRKKFEDQAKELA 181
            ||..:|..   :..|:.:|::..|:....:|..|....:..|...:|...:.:|.|.|:   ...
Zfish   108 LEPMLKNY---STSLQMQLERVKKDKEQLDNELRKAHAQVQEQKQRYEDEIGNRNKAEN---AFV 166

  Fly   182 LENERLRRQLDDLRKQLEAETLARVDLENQNQSLREELAFKDQVHTQELTETRSRRQIEISEIDG 246
            |           |:|.::...|.::.||.:.::::|||.|....:.|||.|.|.  :::.:.:..
Zfish   167 L-----------LKKDVDTTYLGKIALEEKLETIQEELNFFKSFYEQELEELRD--EVKDTSVVV 218

  Fly   247 RLSRQYEAKLQQSLQELRDQYEGQMRINREEIELLYDNEIQNLKAAANRAAQGSALATEEVRLMR 311
            ::.......:::.|.:::.|||.....:|.|.|..|.|:...:.:.||:       .:.|::..:
Zfish   219 QMDNSRNLNMEKILADVKSQYEEISACSRREAEAWYKNKFDLVSSQANQ-------CSTELKNNK 276

  Fly   312 TKIDGLNAKLQNLED--TNA-----GLNARIRELEN-----LLDTERQRHNQYIASLEAELQRMR 364
            ..||.|..|:|.|::  |:|     .:..:|:|.|.     :||...|     |..||..||:.:
Zfish   277 GAIDELKRKIQRLQNDITSAKSQCDNVEEKIKEAERDGEEAVLDATEQ-----IRLLEEALQKAK 336

  Fly   365 DEMAHQLQEYQGLMDIKVSLDLEIAAYDKLLCGEERRL 402
            .|||.||::||.||::|::||:|||.|.|||.|||.|:
Zfish   337 KEMARQLRDYQELMNLKLALDIEIATYKKLLEGEEDRI 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LamC	NP_001260974.1	Filament	45..401	CDD:278467	100/367 (27%)
		ATP-synt_B	<67..>142	CDD:304375	16/74 (22%)
		MreC	<178..>224	CDD:302802	10/45 (22%)
		LTD	473..574	CDD:279300
si:dkey-222n6.2	XP_003199098.1	Keratin_2_head	<23..59	CDD:292825	5/35 (14%)
		Filament	62..373	CDD:278467	100/367 (27%)
		crotonase-like	304..>347	CDD:304874	16/47 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000