DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LamC and KRT15

DIOPT Version :9

Sequence 1:	NP_001260974.1	Gene:	LamC / 36615	FlyBaseID:	FBgn0010397	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	XP_011523086.1	Gene:	KRT15 / 3866	HGNCID:	6421	Length:	463	Species:	Homo sapiens

Alignment Length:	414	Identity:	119/414 - (28%)
Similarity:	190/414 - (45%)	Gaps:	76/414 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 EKEELQHLNDRLACYIDRMRNLENENSRLTQELNLAQDTVNRETSNLK----AVYEKELAAARKL 106
            ||..:|:||||||.|:|::|.||..|:.|..:::   |...::|....    :.|.|.:...|..
Human   105 EKITMQNLNDRLASYLDKVRALEEANADLEVKIH---DWYQKQTPTSPECDYSQYFKTIEELRDK 166

  Fly   107 LDETAKEKAK--LEIDIKRLWEENDDLKPRLDKKTKEATVAENNARLYENRYNEVNGKYNQSLAD 169
            :..|..:.::  ||||..||..::..||            .||...|.:....::||
Human   167 IMATTIDNSRVILEIDNARLAADDFRLK------------YENELALRQGVEADING-------- 211

  Fly   170 RKKFEDQAKELALENERLRRQLDDLRKQLEAETLARVDLENQNQSLREELAFKDQVHTQELTETR 234
                             |||.||:|       ||||.|||.|.:.|.||||:..:.|.:.:....
Human   212 -----------------LRRVLDEL-------TLARTDLEMQIEGLNEELAYLKKNHEEWVPPIL 252

  Fly   235 SRRQIEISEIDGRLSRQYEA----KLQQSLQELRDQYEGQMRINREEIELLYDNEIQ--NLKAAA 293
            ...:...|::.|:::.:.:|    .|.:.|.|:|:|||.....||.::|..:.::.:  |.:.|:
Human   253 QEMKEFSSQLAGQVNVEMDAAPGVDLTRVLAEMREQYEAMAEKNRRDVEAWFFSKTEELNKEVAS 317

  Fly   294 NRAAQGSALATEEVRLMRTKIDGLNAKLQNLE-------DTNAGLNARIRELENLLDTERQRHNQ 351
            |         ||.::..:|:|..|...:|.||       ...|||...:.|.|....|:.|:...
Human   318 N---------TEMIQTSKTEITDLRRTMQELEIELQSQLSMKAGLENSLAETECRYATQLQQIQG 373

  Fly   352 YIASLEAELQRMRDEMAHQLQEYQGLMDIKVSLDLEIAAYDKLLCGEERRLNIESPGRPTTDSGI 416
            .|..|||:|..:|.||..|.|||:.|:|||..|:.|||.|..||.|::.::...:....::..|.
Human   374 LIGGLEAQLSELRCEMEAQNQEYKMLLDIKTRLEQEIATYRSLLEGQDAKMAGIAIREASSGGGG 438

  Fly   417 SSNGSHLTASASSRSGRVTPSGRR 440
            ||:..|:... .|..|:|..|.:|
Human   439 SSSNFHINVE-ESVDGQVVSSHKR 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LamC	NP_001260974.1	Filament	45..401	CDD:278467	110/373 (29%)
		ATP-synt_B	<67..>142	CDD:304375	18/80 (23%)
		MreC	<178..>224	CDD:302802	19/45 (42%)
		LTD	473..574	CDD:279300
KRT15	XP_011523086.1	Filament	104..423	CDD:278467	110/373 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910