DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LamC and KRT5

DIOPT Version :9

Sequence 1:	NP_001260974.1	Gene:	LamC / 36615	FlyBaseID:	FBgn0010397	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_000415.2	Gene:	KRT5 / 3852	HGNCID:	6442	Length:	590	Species:	Homo sapiens

Alignment Length:	415	Identity:	110/415 - (26%)
Similarity:	189/415 - (45%)	Gaps:	56/415 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 RQQEKEELQHLNDRLACYIDRMRNLENENSRLTQELNLAQD----TVNRETSNLKAVYEKELAAA 103
            |.:|:|:::.||::.|.:||::|.||.:|..|..:..|.|:    ||.:   ||:.::|:.:...
Human   165 RTEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWTLLQEQGTKTVRQ---NLEPLFEQYINNL 226

  Fly   104 RKLLDETAKEKAKLEIDIKRLWEENDDLKPRLDKKTKEATVAENNARLYENRYNEVNGKYNQSLA 168
            |:.||....|:.:|:.:::.:.:..:|.|.:.:.:..:.|.|||
Human   227 RRQLDSIVGERGRLDSELRNMQDLVEDFKNKYEDEINKRTTAEN--------------------- 270

  Fly   169 DRKKFEDQAKELALENERLRRQLDDLRKQLEAETLARVDLENQNQSLREELAFKDQVHTQELTET 233
                      |..:           |:|.::|..:.:|:||.:..:|.:|:.|.......||
Human   271 ----------EFVM-----------LKKDVDAAYMNKVELEAKVDALMDEINFMKMFFDAEL--- 311

  Fly   234 RSRRQIEISEIDGRLS--RQYEAKLQQSLQELRDQYEGQMRINREEIELLYDNEIQNLKAAANRA 296
             |:.|..:|:....||  ......|...:.|::.|||.....:|.|.|..|..:.:.|:..|.|.
Human   312 -SQMQTHVSDTSVVLSMDNNRNLDLDSIIAEVKAQYEEIANRSRTEAESWYQTKYEELQQTAGRH 375

  Fly   297 AQGSALATEEVRLMRTKIDGLNAKLQNLEDTNAGLNARIRELENLLDTERQRHNQYIASLEAELQ 361
            .........|:..|...|..|.|::.|::...|.|...|.:.|...:...:.....:|.||..||
Human   376 GDDLRNTKHEISEMNRMIQRLRAEIDNVKKQCANLQNAIADAEQRGELALKDARNKLAELEEALQ 440

  Fly   362 RMRDEMAHQLQEYQGLMDIKVSLDLEIAAYDKLLCGEERRLNIESPGRPTTDSGISSNGSHLTAS 426
            :.:.:||..|:|||.||:.|::||:|||.|.|||.|||.||:.|..| |...|.::|:.|....|
Human   441 KAKQDMARLLREYQELMNTKLALDVEIATYRKLLEGEECRLSGEGVG-PVNISVVTSSVSSGYGS 504

  Fly   427 ASSRSGRVTPSGRRSATPGISGSSA 451
            .|...|.:..........|::|.|:
Human   505 GSGYGGGLGGGLGGGLGGGLAGGSS 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LamC	NP_001260974.1	Filament	45..401	CDD:278467	95/361 (26%)
		ATP-synt_B	<67..>142	CDD:304375	18/78 (23%)
		MreC	<178..>224	CDD:302802	10/45 (22%)
		LTD	473..574	CDD:279300
KRT5	NP_000415.2	Head	1..167		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		Keratin_2_head	16..164	CDD:292825
		Filament	167..480	CDD:278467	95/361 (26%)
		Coil 1A	168..203		12/34 (35%)
		Linker 1	204..222		6/20 (30%)
		Coil 1B	223..315		24/137 (18%)
		Linker 12	316..338		4/21 (19%)
		Coil 2	339..477		44/137 (32%)
		DUF883	393..>453	CDD:295076	16/59 (27%)
		Tail	478..590		15/53 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	566..590
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910