DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LamC and KRT4

DIOPT Version :9

Sequence 1:	NP_001260974.1	Gene:	LamC / 36615	FlyBaseID:	FBgn0010397	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_002263.3	Gene:	KRT4 / 3851	HGNCID:	6441	Length:	520	Species:	Homo sapiens

Alignment Length:	472	Identity:	122/472 - (25%)
Similarity:	209/472 - (44%)	Gaps:	93/472 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 GASTSSRVGATSPTSPT------------------------RTSRQQEKEELQHLNDRLACYIDR 63
            |.|.|.:.|...|..|.                        :..|.:|:|:::.||::.|.:||:
Human    90 GGSFSGKGGPGFPVCPAGGIQEVTINQSLLTPLHVEIDPEIQKVRTEEREQIKLLNNKFASFIDK 154

  Fly    64 MRNLENENSRLTQELN-LAQDTVNRETSNLKAVYEKELAAARKLLDETAKEKAKLEIDIKRLWEE 127
            ::.||.:|..|..:.| |.|.|....:.||:.::|..|:..||.||....:|.:|:.::|.:.:.
Human   155 VQFLEQQNKVLETKWNLLQQQTTTTSSKNLEPLFETYLSVLRKQLDTLGNDKGRLQSELKTMQDS 219

  Fly   128 NDDLKPRLDKKTKEATVAENNARLYENRYNEVNGKYNQSLADRKKFEDQAKELALENERLRRQLD 192
            .:|.|.:.:::..:.|.|||:..:
Human   220 VEDFKTKYEEEINKRTAAENDFVV----------------------------------------- 243

  Fly   193 DLRKQLEAETLARVDLENQNQSLREELAFKDQVHTQELTETRSRRQIEISEIDGRLS--RQYEAK 255
             |:|.::|..|.:|:||.:..||.:|:.|...::..||    |:.|..:|:....||  ......
Human   244 -LKKDVDAAYLNKVELEAKVDSLNDEINFLKVLYDAEL----SQMQTHVSDTSVVLSMDNNRNLD 303

  Fly   256 LQQSLQELRDQYEGQMRINREEIELLYDNEIQNLKAAANRAAQGSALATEEVRLMRTKIDGLNAK 320
            |...:.|:|.|||...:.::.|.|.||..::|.|:.:.::..........|:..:...|..|.|:
Human   304 LDSIIAEVRAQYEEIAQRSKAEAEALYQTKVQQLQISVDQHGDNLKNTKSEIAELNRMIQRLRAE 368

  Fly   321 LQNLEDTNAGLNARIRELEN-----LLDTERQRHNQYIASLEAELQRMRDEMAHQLQEYQGLMDI 380
            ::|::.....|...:.:.|.     |.|...:|     ..|||.||:.::|:|..|:|||.||.:
Human   369 IENIKKQCQTLQVSVADAEQRGENALKDAHSKR-----VELEAALQQAKEELARMLREYQELMSV 428

  Fly   381 KVSLDLEIAAYDKLLCGEERRLNIESPGRPTTD--SGISSNGSHLTASASSRSGRVTPSGRRSAT 443
            |::||:|||.|.|||.|||.|::.|.....:..  ||.:|.|. ::....|.||....||..|.:
Human   429 KLALDIEIATYRKLLEGEEYRMSGECQSAVSISVVSGSTSTGG-ISGGLGSGSGFGLSSGFGSGS 492

  Fly   444 -------PGISGSSAVK 453
                   ..:||||:.|
Human   493 GSGFGFGGSVSGSSSSK 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LamC	NP_001260974.1	Filament	45..401	CDD:278467	98/363 (27%)
		ATP-synt_B	<67..>142	CDD:304375	21/75 (28%)
		MreC	<178..>224	CDD:302802	11/45 (24%)
		LTD	473..574	CDD:279300
KRT4	NP_002263.3	Head	1..136		7/45 (16%)
		Keratin_2_head	14..133	CDD:406589	6/42 (14%)
		Filament	136..449	CDD:365827	98/363 (27%)
		Coil 1A	137..172		12/34 (35%)
		Linker 1	173..191		5/17 (29%)
		Coil 1B	192..284		28/137 (20%)
		Linker 12	285..307		4/21 (19%)
		Coil 2	308..447		45/143 (31%)
		Tail	448..520		17/63 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..520		5/10 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910