DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LamC and KRT1

DIOPT Version :9

Sequence 1:	NP_001260974.1	Gene:	LamC / 36615	FlyBaseID:	FBgn0010397	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_006112.3	Gene:	KRT1 / 3848	HGNCID:	6412	Length:	644	Species:	Homo sapiens

Alignment Length:	421	Identity:	112/421 - (26%)
Similarity:	206/421 - (48%)	Gaps:	72/421 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 RQQEKEELQHLNDRLACYIDRMRNLENENSRLTQELNLAQ--DTVNRETSNLKAVYEKELAAARK 105
            :.:|:|:::.||::.|.:||::|.||.:|..|..:..|.|  ||..| |.||:..:|..:...|:
Human   177 KSREREQIKSLNNQFASFIDKVRFLEQQNQVLQTKWELLQQVDTSTR-THNLEPYFESFINNLRR 240

  Fly   106 LLDETAKEKAKLEIDIKRLWEENDDLKPRLDKKTKEATVAENNARLYENRY-NEVNGKYNQSLAD 169
            .:|:...::::|:.::|.:.:..:|                     |.|:| :|:|.:.|
Human   241 RVDQLKSDQSRLDSELKNMQDMVED---------------------YRNKYEDEINKRTN----- 279

  Fly   170 RKKFEDQAKELALENERLRRQLDDLRKQLEAETLARVDLENQNQSLREELAFKDQVHTQELTETR 234
                        .|||.:     .::|.::...:.:|||:.:..:|::|:.|...::..||
Human   280 ------------AENEFV-----TIKKDVDGAYMTKVDLQAKLDNLQQEIDFLTALYQAEL---- 323

  Fly   235 SRRQIEISEIDGRLS--RQYEAKLQQSLQELRDQYEGQMRINREEIELLYDNEIQNLKAAANR-- 295
            |:.|.:|||.:..||  ......|...:.|::.|||...:.::.|.|.||.::.:.|:..|.|
Human   324 SQMQTQISETNVILSMDNNRSLDLDSIIAEVKAQYEDIAQKSKAEAESLYQSKYEELQITAGRHG 388

  Fly   296 -AAQGSALATEE----VRLMRTKIDGLNAKLQNLEDTNAGLNARIRELENLLDTERQRHNQYIAS 355
             :.:.|.:...|    ::.:|::||.:..::.||:.:.:....|   .||.|...:.:.|    .
Human   389 DSVRNSKIEISELNRVIQRLRSEIDNVKKQISNLQQSISDAEQR---GENALKDAKNKLN----D 446

  Fly   356 LEAELQRMRDEMAHQLQEYQGLMDIKVSLDLEIAAYDKLLCGEERRLNIESPGRPTTDSGISSNG 420
            ||..||:.::::|..|::||.||:.|::||||||.|..||.|||.|::    |....:..:|.:.
Human   447 LEDALQQAKEDLARLLRDYQELMNTKLALDLEIATYRTLLEGEESRMS----GECAPNVSVSVST 507

  Fly   421 SHLTAS-ASSRSGRVTPSGRRSATPGISGSS 450
            ||.|.| ..||.|.....|...::.|..|.|
Human   508 SHTTISGGGSRGGGGGGYGSGGSSYGSGGGS 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LamC	NP_001260974.1	Filament	45..401	CDD:278467	98/367 (27%)
		ATP-synt_B	<67..>142	CDD:304375	18/76 (24%)
		MreC	<178..>224	CDD:302802	10/45 (22%)
		LTD	473..574	CDD:279300
KRT1	NP_006112.3	Head	2..179		0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..47
		Keratin_2_head	<145..176	CDD:292825
		Filament	180..492	CDD:278467	98/366 (27%)
		Coil 1A	180..215		12/34 (35%)
		Linker 1	216..234		8/18 (44%)
		Coil 1B	235..326		24/137 (18%)
		Linker 12	327..350		7/22 (32%)
		Coil 2	351..489		43/144 (30%)
		DUF883	405..>465	CDD:295076	16/66 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	489..523		12/37 (32%)
		Tail	490..644		15/53 (28%)
		Keratin_2_tail	493..>512	CDD:292827	4/22 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	568..644
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910