DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LamC and Krt5

DIOPT Version :9

Sequence 1:	NP_001260974.1	Gene:	LamC / 36615	FlyBaseID:	FBgn0010397	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_899162.2	Gene:	Krt5 / 369017	RGDID:	727894	Length:	576	Species:	Rattus norvegicus

Alignment Length:	462	Identity:	115/462 - (24%)
Similarity:	196/462 - (42%)	Gaps:	100/462 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 RQQEKEELQHLNDRLACYIDRMRNLENENSRLTQELNLAQD----TVNRETSNLKAVYEKELAAA 103
            |.:|:|:::.||::.|.:||::|.||.:|..|..:..|.|:    |:.:   ||..::|:.:...
  Rat   161 RTEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWTLLQEQGTKTIKQ---NLDPLFEQYINNL 222

  Fly   104 RKLLDETAKEKAKLEIDIKRLWEENDDLKPRLDKKTKEATVAENNARLYENRY-NEVNGKYNQSL 167
            |:.||....|:.:|:.:::.:.:..:|                     |:|:| :|:|
  Rat   223 RRQLDGVMGERGRLDSELRNMQDLVED---------------------YKNKYEDEIN------- 259

  Fly   168 ADRKKFEDQAKELALENERLRRQLDDLRKQLEAETLARVDLENQNQSLREELAFKDQVHTQELTE 232
                      |....|||.:.     |:|.::|..:.:|:||.:..:|.:|:.|.......||
  Rat   260 ----------KRTTAENEFVM-----LKKDVDAAYMNKVELEAKVDALMDEINFMKMFFDAEL-- 307

  Fly   233 TRSRRQIEISEIDGRLS--RQYEAKLQQSLQELRDQYEGQMRINREEIELLYDNEIQNLKAAANR 295
              |:.|..:|:....||  ......|...:.|::.|||.....:|.|.|..|..:.:.|:..|.|
  Rat   308 --SQMQTHVSDTSVVLSMDNNRSLDLDSIIAEVKAQYEDIANRSRTEAESWYQTKYEELQQTAGR 370

  Fly   296 AAQGSALATEEVRLMRTKIDGLNAKLQNLEDTNAGLNARIRELENLLDTERQRHNQYIASLEAEL 360
            ..........|:..|...|..|.:::.|::...|.|...|.|.|...:...:.....:..||..|
  Rat   371 HGDDLRNTKHEISEMNRMIQRLRSEIDNVKKQCANLQNAIAEAEQRGELALKDARNKLTELEEAL 435

  Fly   361 QRMRDEMAHQLQEYQGLMDIKVSLDLEIAAYDKLLCGEERRLNIESPG----------------- 408
            |:.:.:||..|:|||.||:.|::||:|||.|.|||.|||.||:.|..|
  Rat   436 QKAKQDMARLLREYQELMNTKLALDVEIATYRKLLEGEECRLSGEGVGPVNISVVTNSLSSGYGG 500

  Fly   409 --------------------------RPTTDSGISSNGSHLTASASSRSGRVTPSGRRSATPGIS 447
                                      |....||:|..||..:||:....|..:..|..|:...:|
  Rat   501 RSNIGYGSGLGSGIGGFASDIGPLLNRRGLGSGLSVGGSGFSASSGQGGGFSSGGGSSSSVKFVS 565

  Fly   448 GSSAVKR 454
            .:|:.:|
  Rat   566 TTSSSRR 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LamC	NP_001260974.1	Filament	45..401	CDD:278467	96/362 (27%)
		ATP-synt_B	<67..>142	CDD:304375	16/78 (21%)
		MreC	<178..>224	CDD:302802	13/45 (29%)
		LTD	473..574	CDD:279300
Krt5	NP_899162.2	Head. /evidence=ECO:0000255	1..163		1/1 (100%)
		Keratin_2_head	16..160	CDD:406589
		Filament	163..476	CDD:365827	96/362 (27%)
		Coil 1A. /evidence=ECO:0000255	164..199		12/34 (35%)
		Linker 1. /evidence=ECO:0000255	200..218		5/20 (25%)
		Coil 1B. /evidence=ECO:0000255	219..311		27/138 (20%)
		Linker 12. /evidence=ECO:0000255	312..334		4/21 (19%)
		Coil 2. /evidence=ECO:0000255	335..473		43/137 (31%)
		Tail. /evidence=ECO:0000255	474..576		19/99 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	540..576		8/33 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910