DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LamC and Krt19

DIOPT Version :9

Sequence 1:	NP_001260974.1	Gene:	LamC / 36615	FlyBaseID:	FBgn0010397	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_955792.1	Gene:	Krt19 / 360626	RGDID:	619936	Length:	403	Species:	Rattus norvegicus

Alignment Length:	412	Identity:	119/412 - (28%)
Similarity:	192/412 - (46%)	Gaps:	82/412 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 NTRVSRASTSTPVGGASTSSRVGATSPTSPTRTSRQQEKEELQHLNDRLACYIDRMRNLENENSR 73
            :||:..:|:...|||.. .|..||.:.|......  .||..:|:||||||.|:|::|.||..|..
  Rat    49 STRIVSSSSGGYVGGRG-GSFSGALTVTDGLLGG--NEKITMQNLNDRLASYLDKVRALEQANGE 110

  Fly    74 LTQELNLAQDTVNRETSNLKAVYEKELAAARKLLDETAKEKAKLEIDIKRLWEENDDLKPRLDKK 138
            |..:              ::..|:|:.....:              |..:.::..:||:.::...
  Rat   111 LEVK--------------IRDWYQKQGPGPFR--------------DYSQYFKTIEDLRDKILGA 147

  Fly   139 TKE---ATVAENNARLYENRYNEVNGKYNQSLADRKKFE-DQAKELALENE--RLRRQLDDLRKQ 197
            |.|   ..:..:||||..:.:             |.||| :||..:::|.:  .|||.||:|
  Rat   148 TIENSKIVLQIDNARLAADDF-------------RTKFETEQALRMSVEADINGLRRVLDEL--- 196

  Fly   198 LEAETLARVDLENQNQSLREELAFKDQVHTQELTETRSRRQIEISEIDGRLSRQYEA----KLQQ 258
                ||||.|||.|.::|:||||:..:.|.:|::..|       |::.|::|.:.::    .|.:
  Rat   197 ----TLARTDLEMQIENLKEELAYLKKNHEEEISALR-------SQVGGQVSVEVDSTPGIDLAK 250

  Fly   259 SLQELRDQYEGQMRINREEIELLYDNEIQNLKAAANRAAQGSALATEEVRLMRTKIDGLNAKLQN 323
            .|.|:|.|||.....||::.|..|..:|..|....       |:.|.::::.:|::..|..|:|:
  Rat   251 ILSEMRSQYEAMAEKNRKDAEAWYLTQIDELNTQV-------AVHTTQIQINKTEVTELRRKVQD 308

  Fly   324 LE-------DTNAGLNARIRELENLLDTERQRHNQYIASLEAELQRMRDEMAHQLQEYQGLMDIK 381
            ||       ...|.|...:.|:|.....:.......|:|:|.:|..:|.:...|.||||.|||||
  Rat   309 LEIELQSQLSMKAALEGTVAEIEARYGAQLSHIQGVISSIEVQLSNVRADTERQNQEYQQLMDIK 373

  Fly   382 VSLDLEIAAYDKLLCGEERRLN 403
            ..|:.|||.|..||.|:|...|
  Rat   374 SRLEQEIATYRSLLEGQEAHYN 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LamC	NP_001260974.1	Filament	45..401	CDD:278467	108/372 (29%)
		ATP-synt_B	<67..>142	CDD:304375	11/77 (14%)
		MreC	<178..>224	CDD:302802	20/47 (43%)
		LTD	473..574	CDD:279300
Krt19	NP_955792.1	Head	1..82		10/35 (29%)
		Filament	82..393	CDD:278467	108/372 (29%)
		Coil 1A	83..118		16/48 (33%)
		Linker 1	119..136		3/30 (10%)
		Coil 1B	137..228		36/110 (33%)
		Linker 12	229..251		5/28 (18%)
		Necessary for interaction with PNN. /evidence=ECO:0000250	247..393		49/152 (32%)
		Coil 2	252..390		46/144 (32%)
		Rod-like helical tail	391..403		2/5 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000